bed below are rarely seen as initial symptoms of the adverse
reactions indicated in brackets. If any of these symptoms occur, stop taking this
medicine and see your doctor immediately.
• shortness of breath, respiratory distress, fever [interstitial lung disease]
• muddy or watery stool, abdominal pain, dehydration [severe diarrhea]
• acne-like rash, pain/heat sensation/redness/swelling around nails [severe dermopathy]
• general malaise, loss of appetite, yellowing of the skin and the white of eyes [liver dysfunction]
The above symptoms do not describe all the adverse reactions to this medicine.
Consult with your doctor or pharmacist if you notice any symptoms of concern other
than those listed above.
Storage conditions and other information
• Keep out of reach of children. Store away from direct sunlight, heat and moisture.
• Discard the remainder. Do not store them.If you dispose of unused medicines, ask the pharmacist or the
medical institution how to discard them.
Internal
Published: 02/2019
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval
details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is
important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response,
patients should understand their medication and cooperate with the treatment.
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