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Prempro（Conjugated/Estrogens）
Generic Name and Formulations:
Conjugated estrogens 0.3mg, medroxyprogesterone acetate 1.5mg; tabs.
Company:
Pfizer Inc.
Indications for PREMPRO 0.3mg/1.5mg:
In women with an intact uterus: moderate to severe vasomotor symptoms due to menopause; moderate to severe vulvar and vaginal atrophy due to menopause; postmenopausal osteoporosis prevention (consider alternative treatments).
Adult Dose for PREMPRO 0.3mg/1.5mg:
1 tab once daily.
Children's Dose for PREMPRO 0.3mg/1.5mg:
Not applicable.
See Also:
PREMPRO 0.45mg/1.5mg
PREMPRO 0.625mg/2.5mg
PREMPRO 0.625mg/5mg
Pharmacological Class:
Estrogen + progestin.
Contraindications:
Known, suspected, or history of breast cancer. Known or suspected estrogen-dependent neoplasia. Undiagnosed abnormal genital bleeding. Pulmonary embolism/DVT (active or history of). Arterial thromboembolism (eg, stroke, MI; active or history of). Protein C, protein S, or antithrombin deficiency, or other known thromboembolic disorders. Liver dysfunction or disease. Known or suspected pregnancy (Cat.X).
Warnings/Precautions:
Not for prevention of cardiovascular disease. Use for shortest duration consistent with treatment goals and risks. Reeva luate periodically. Gallbladder disease. Hypercalcemia in breast cancer or bone metastases. Conditions aggravated by fluid retention. Familial hyperlipidemia. Hypercoagulation states. Hereditary angioedema. Do initial complete physical and repeat at least yearly (include BP, PAP smear, mammogram). Discontinue if cardiovascular events or visual abnormalities occur or are suspected; if jaundice occurs; and during immobilization for at least 4–6 weeks before surgery associated with thromboembolism. May interfere with lab tests; see literature. Nursing mothers: not recommended.
Adverse Reactions:
See literature. Increased risk of cardiovascular events, breast cancer (in prolonged use). GI upset, pain, cramps, hepatic impairment, mastodynia, breakthrough bleeding, altered cervical secretion, vaginal infections, edema, worsening of porphyria, headache, migraine, dizziness, dementia, changes in vision, intolerance to contact lenses, hair loss, weight or libido changes, anaphylactic reactions, angioedema.
How Supplied:
Blister card (28 tabs)—1
更年期女性慎用激素替代疗法
美国的一项最新研究表明，一种用于缓解女性更年期综合征的激素药物Prempro可能与女性肺癌患者死亡风险的增加有关。为此，他们建议更年期女性谨慎对待类似激素替代疗法。
由惠氏制药公司生产的Prempro是一种包含雌激素和黄体酮的复合药物，它虽然对推迟妇女更年期有一定效果，但因被怀疑有增加患心脏病、乳腺癌和中风的危险，一直颇受争议。
美国加州大学洛杉矶分校哈伯医学中心的研究人员对16608名更年期女性进行了研究。这些女性在被调查初期并未患上肺癌，但在调查结束时，其中一部分妇女因多种原因患上肺癌。
研究人员将被调查对象分为两组，一组服用Prempro，而对照组服用安慰剂。研究结果显示，虽然服用Prempro并未使被调查者患非小细胞肺癌的风险增加，但对于那些因多种原因患上这种疾病的人而言，服用Prempro使他们的死亡风险高出对照组两倍。非小细胞肺癌是最为普遍的一种肺癌，约占肺癌发病总数的80%。
研究人员指出，该研究成果再次表明，人们应更谨慎地采用激素替代疗法治疗更年期综合征，而对那些已经采取这一疗法的人来说应考虑降低剂量。此外，研究人员尤其不建议吸烟的更年期女性采用激素替代疗法，因为吸烟是导致肺部疾病发生的重要原因之一。
研究人员在美国佛罗里达州举行的肿瘤学会会议上报告了上述研究成果。
Brand name: Prempro
Generic name: Conjugated Estrogens
Used for: Treats Symptoms of menopause
Alternatives: Activella, Climara patch, Combipatch, Premarin
Availability: Brand, Pfizer, Wyeth Prempro and generic Prempro tablets are available in strengths 0.625 mg/2.5 mg, 0.625 mg/5 mg, 0.3 mg/0.15 mg doses
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How Prempro Works
Prempro is a combination medication used to treat the symptoms of menopause, such as hot flashes, vaginal dryness, and irritation. Prempro contains a combination of conjugated estrogens and medroxyprogesterone. Conjugated estrogens are a hormone that is found in the ovaries, and medroxyprogesterone is also a female hormone that is essential for the regulation of ovulation and menstruation. During menopause women experience a drop in estrogen levels in the body, with a drop in these estogen levels comes along a handful of bothersome side effects such as hot flashes, irritability and vaginal dryness. By replenishing the estrogen levels in the body the symptoms of menopause can be very manageable.
Prempro Possible Side Effects
All medications unfortunately do come along with some unwanted side effects. The following are the side effects of Prempro:
• Mild nausea
• Breast pain
• Acne
• Changes in weight or appetite
• Headache
Contact your doctor if you experience any of the following:
• Chest pain or heavy feeling
• Sudden numbness or weakness
• Abnormal vaginal bleeding
• Migraine headache
• Jaundice
• Swelling of your hands, ankles or feet
• A breast lump
Prempro Guidelines
Do not Prempro if you are allergic to any of the ingredients in Prempro. Prempro is only to be taken who still have their uterus. Prempro should not be used to prevent heart disease or dementia. Do not take Prempro if you have a history of heart attacks, stroke, or blood clots. Prempro is a prescription required medication and should only be taken after a thorough examination is performed by your doctor. Be sure to take Prempro exactly how it is prescribed to you and contact your doctor regarding missed doses. Prempro is generally a short term treatment. Long term treatment of Prempro can increase the risk of breast cancer. Be sure to inform your prescribing doctor of all your current and pre-existing medical conditions and all subsequent medications you may be taking.
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