部份中文盐酸维拉帕米处方资料（仅供参考）
商品名：Vasolan
英文名：Verapamil Hydrochloride
中文名：盐酸维拉帕米
生产商：卫材制药
药品介绍
VERAPAMIL是一种「钙离子阻断剂」的降血压及预防心绞痛的药物。其作用是能使血管扩张，让更多的血液能够顺畅地通过血管，而达到降血压目的。
ワソラン錠40mg
药用类别名称
Ca++拮抗心律失常/缺血性心脏病治疗剂
批准日期：2006年12月
商標名
Vasolan
一 般 名
ベラパミル塩酸塩 (Verapamil Hydrochloride)
(別　名)
塩酸イプロベラトリル
化 学 名
(2RS)‐5‐［(3,4‐Dimethoxyphenethyl)methylamino］‐2‐(3,4‐dimethoxyphenyl)‐2‐(1‐methylethyl) pentanenitrile monohydrochloride
分 子 式
C27H38N2O4・HCl
分 子 量
491.06
構 造 式
物理化学的性状
盐酸维拉帕米是一种白色结晶性粉末, 无异味。
本品为甲醇, 易溶于醋酸 (100) 或氯仿, 微溶于乙醇 (95) 或无水乙酸, 几乎不溶于水, 不易溶于乙醚。
熔点
141至145°c
药用药理学
1. 作用机制
该药物的作用机制是一种基于细胞内流入抑制细胞外液体Ca+的钙+拮抗。
2. 降低周围血管阻力, 减少心脏工作量
如果这种药物口服给缺血性心脏病患者, 慢慢降低血压, 心率也会略有降低。 因此, 心脏工作量减少, 心肌耗氧量也被抑制。
3. 扩展冠状动脉和外周血管
在使用犬切除心肌和麻醉犬的实验中, 激发含有冠状动脉的血管平滑肌抑制收缩链, 增加冠状动脉血流, 降低外周血管阻力。
4. 显示心肌保护效果
缺血、高血压、存在过量的细胞内游离钙++, 对于心肌退行性变的原因是心肌内 atp 缺乏引起的过量儿茶酚胺, 该药物对这些抑制心肌退化的各种因素具有拮抗作用, 它已被证实的大鼠和兔子保护心肌。
5. 抑制Ca++流入, 并表现出抗心律失常的效果
在使用豚鼠和家兔切除心肌的实验中, 已证实可以抑制Ca++ 通过慢通道的流入。 此外, 在麻醉犬的实验中, 特别是房室传导系统的活动期, 通过作用于房室结节, 以延长功能非相向, 以延缓房室传导。
6. 通过去甲肾上腺素和电刺激抑制实验性心律失常
(1) 在使用犬给左心肌切除的实验中, 减少或显著降低去甲肾上腺素房室结节局部给药引起的上室性心动过速。
(2) 在使用麻醉犬的实验中, 降低电刺激引起的心房颤动时的心室率。
适应症
* 成人
心动过速(心房颤动, 粗糙运动, 阵发性心动过速)
心绞痛、心肌梗死 (急性期除外)、其他缺血性心脏病
* 儿科
心动过速(心房颤动, 粗糙运动, 阵发性心动过速)
用法与用量
*成人
心动过速 (心房颤动, 粗糙运动, 阵发性心动过速)
通常成人, 一次1-2 片(一次40至80毫克作为盐酸维拉帕米), 每天口服三次。另外, 年龄, 要靠适当的减肥症状。
心绞痛、心肌梗死 (急性期除外)、其他缺血性心脏病
通常成人, 一次1-2 片(一次40至80毫克作为盐酸维拉帕米), 每天口服三次。应该注意的是, 年龄, 根据症状增加或减少。
*儿科
心动过速(心房颤动, 粗糙运动, 阵发性心动过速)
通常情况下, 孩子, 1天 3 ~ 6mggskg 作为盐酸贝拉帕米(但不超过 1天240毫克), 口服分为每天三次。另外, 年龄, 要靠适当的减肥症状。
临床结果
临床疗效
在一般临床试验中证实了对缺血性心脏病如运动和静息心绞痛和陈氏老年心肌梗死的疗效。
该药物改善了与缺血性心脏病相关的狭窄心痛, 降低了狭窄的心脏病发作次数和硝酸盐剂量的舌下消耗, 显示了改善静息心电图和负荷心电图的效果。
同时提高运动耐受性。
包装
日本药典西拉帕米盐酸盐片
片40mg:100 片 (ptp/rose)
日本药典西拉帕米盐酸盐片
40mg:1000 片 (ptp/rose)
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明书资料附件：http://www.info.pmda.go.jp/go/pack/2171008F1070_1_05/
Vasolan Tablets 40mg（Verapamil hydrochloride）
Brand name:
Vasolan Tablets 40mg
　Active ingredient:
Verapamil hydrochloride
　Dosage form:
yellowish green tablet, diameter: 7.2 mm, thickness: 4.0 mm
　Print on wrapping:
(Face) ワソラン40mg, E213
(Back) ワソラン, 40mg, E213, Vasolan
Effects of this medicine
This medicine has calcium antagonistic action to inhibit calcium influx of extracellular fluid into cells, and delays the excitation-conduction of the heart to correct irregular heart beats due to tachyarrhythmia. It also dilates the coronary arteries to increase the blood flow to the heart and the peripheral vessels to reduce the work load of the heart. It consequently suppresses the symptoms such as chest pain due to myocardial ischemia.
It is usually used for treatment of atrial fibrillation, atrial flutter, paroxysmal supraventricular tachycardia, angina, myocardial infarction or other ischemic heart diseases.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rach, etc.) to any medicines.
If you have congestive heart failure, atrioventricular block, sinoatrial block, hypotension, cardiomyopathy, valvular disease, hypertensive heart disease, hepatic failure, renal failure or muscular dystrophy.
If you are pregnant, possibility pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is (to be written by a healthcare professional)
For treatment of atrial fibrillation, atrial flutter or paroxysmal supraventricular tachycardia: In general, for adults, take one or two tablets (40 to 80 mg as active ingredient) at a time, 3 times a day, to be reduced depending on the disease, severity of the symptoms or age. Strictly follow the instructions.
For treatment of angina, myocardial infarction or other ischemic heart diseases: In general, for adults, take one or two tablets (40 to 80 mg as active ingredient) at a time, 3 times a day, to be adjusted depending on the disease, severity of the symptoms or age. Strictly follow the instructions.
For children's tachyarrhythmia (atrial fibrillation, atrial flutter or paroxysmal supraventricular tachycardia): In general, for children, take 3 to 6 mg/kg of the active ingredient daily in 3 divided doses, however, the maximum daily dose should be 240 mg. The dosage may be decreased according to the disease, age or symptoms. 1 tablet contains 40 mg of the active ingredient. Strictly follow the instructions.
If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Grapefruit juice may potentiate the effect and adverse reactions of this medicine. Do not take this medicine with grapefruit juice.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, gum hypertrophy, constipation, headache, decrease in blood pressure, dizziness, nausea and vomiting. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
difficulty in breathing, dizziness, loss of consciousness [heart failure, sinus arrest, atrioventricular block, bradycardia, unconsciousness]
fever, widespread flat reddish patches, bloodshot eyes, stomatitis [mucocutaneous ocular syndrome, erythema exsudativum multiforme, psoriasiform eruption]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep this medicine out of the reach of children and away from light, heat and moisture.
If you have leftover medicines, dispose of them appropriately and do not keep any unused medicine.
Eisai Co., Ltd.
Internal
Revised: 3/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.