部份中文阿地溴铵处方资料（仅供参考）
英文名：Aclidinium bromide
商品名：Eklira Genuair
中文名：阿地溴铵吸入雾化粉
生产商：杏林药业
药品简介近日，吸入雾化粉Eklira Genuair（Aclidinium bromide）在日本获批上市，该药是一种支气管扩张剂，用于慢性阻塞性肺病（COPD）的治疗。
エクリラ400μgジェヌエア30吸入用/エクリラ400μgジェヌエア60吸入用
药效分类名
COPD治疗
批准日期：2015年5月
商品名
Eklira Genuair
一般的名称
アクリジニウム臭化物（Aclidinium Bromide）［JAN］
化学名
(3R)-3-[2-Hydroxy-2,2-di(thiophen-2-yl)acetyloxy]-1-(3-phenyloxypropyl)-1-azoniabicyclo[2.2.2]octanebromide
分子式
C26H30BrNO4S2
分子量
564.56
性状
它是白色或几乎白色的粉末。微溶于甲醇，微溶于水和乙醇，几乎不溶于丙酮，乙酸乙酯，四氢呋喃和甲苯。
化学结构式
熔点
224-229摄氏度
处理注意事项
遵守地方政府制定的废物处理法律。
批准条件
制定风险管理计划并适当实施。
药物药理学
作用机理
溴化din啶是一种长效毒蕈碱受体拮抗剂，可通过与气道平滑肌中的毒蕈碱M3受体结合来抑制乙酰胆碱的收缩作用。
毒蕈碱受体的亲和力
啶鎓对所有毒蕈碱型M1-M5受体均具有高亲和力，其亲和力与噻托溴铵相当。同样（啶鎓从M3受体的解离比M2受体（体外）慢。
气管收缩抑制
溴化din啶对卡巴胆碱诱导的豚鼠离体气管收缩具有抑制作用（体外）。
行动的开始和持续
cri啶鎓抑制豚鼠乙酰胆碱诱导的气道收缩。它的起效快于噻托溴铵，与异丙托溴铵相当。而且，其持续时间比噻托溴铵短，并且比异丙托溴铵长。
适应症
缓解基于气道阻塞性疾病的慢性阻塞性肺疾病（慢性支气管炎，肺气肿）的各种症状
用法与用量
通常，对于成年人，每天两次，每次1次吸入（阿地溴铵为400μg）。
包装
400微克 30吸入用
吸入器：1个
400微克 60吸入用
吸入器：1个
制造与销售
诺华制药公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明附件：
https://www.info.pmda.go.jp/go/pack/2259713G1023_1_04/
Eklira 400mcg Genuair(Aclidinium Bromide)
Brand name: Eklira 400mcg Genuair 30 doses
　Active ingredient: Aclidinium Bromide
　Dosage form: inhaled dry powder, white body with a green cap and a green button
　Print on wrapping: エクリラ400μgジェヌエア30吸入用
Effects of this medicine
This medicine is a long acting muscarinic receptor antagonist to improve respiratory function by dilating bronchi over a long time.
It is usually used to ameliorate various symptoms due to airway obstructive disorders in patients with chronic obstructive pulmonary disease(chronic bronchitis, emphysema). It is designed to be routinely inhaled every day.Therefore, it does not provide prompt relief of acute progression of the symptoms.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions(itch, rash, etc.) to any medicines.
If you have: angle-closure glaucoma, difficulty in urination due to prostate hypertrophy etc.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is<<to be written by a healthcare professional>>
•In general for adults, take one inhalation of the medicine (400 mcg of the active ingredient), twice daily. Strictly follow the specified instructions.
•Read carefully the instruction leaflet "To Patients Using Eklira 400mcg Genuair ".
•When you firmly press button, the dose counter (display every 10 times) on an adapter works automatically left step by step and changes 20, 10, 0 in turn. Confirm the counter every day. When you begin to see red line, you should contact your doctor for a replacement inhaler. When this is getting to zero, the button is locked and you can take one inhalation finally.
•If you miss a dose, inhale a dose as soon as possible when you remember that you missed a dose. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never inhale two doses at one time.
•If you accidentally inhale more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop inhaling this medicine unless your doctor instructs you to do so.
Kyorin Pharmacetical Co.,LtdExternal
Published: 5/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits).It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.