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Maxalt RPD Tablets 6×10mg(Rizatriptan benzoate 利扎曲普坦口腔崩解片)
药店国别  
产地国家 日本 
处 方 药: 是 
所属类别 10毫克/片 6片/盒 
包装规格 10毫克/片 6片/盒 
计价单位: 盒 
生产厂家中文参考译名:
卫材有限公司
生产厂家英文名:
Eisai Co.Ltd.
该药品相关信息网址1:
https://www.info.pmda.go.jp/go/pack/2160006F1026_2_13/
该药品相关信息网址2:
该药品相关信息网址3:
原产地英文商品名:
Maxalt(マクサルトRPD錠)10mg/Tablet 6Tablets/box
原产地英文药品名:
Rizatriptan Benzoate
中文参考商品译名:
Maxalt(マクサルトRPD錠)10毫克/片 6片/盒
中文参考药品译名:
苯甲酸利扎曲普坦
曾用名:
简介:

 

部份中文苯甲酸利扎曲普坦处方资料(仅供参考)
英文名:Rizatriptan Benzoate
商品名:Maxalt RPD Tablets
中文名:苯甲酸利扎曲普坦口腔崩解片
生产商:卫材有限公司
药品简介
Maxalt(Rizatriptan Benzoate,マクサルト,苯甲酸利扎曲普坦) 是一种5-HT1激动剂,由默沙东开发上市,剂型有片剂和口腔崩解片,用于治疗偏头痛。
マクサルト錠10mg/マクサルトRPD錠10mg
薬效分类名
5-HT1B/1D受容体作动型片头痛治疗剤
批准日期:2003年 9月
商品名
Maxalt
一般的名称
リザトリプタン安息香酸塩
(Rizatriptan Benzoate)[JAN]
化学名
3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-
triazol-1-ylmethyl)indole monobenzoate
分子式
C15H19N5・C7H6O2
分子量
391.47
性状
它是白色粉末。
微溶于水或甲醇,微溶于乙醇(95),微溶于乙腈,微溶于二乙醚。
化学構造式
分配系数

  • 有機溶媒相
  • 水相
  • 分配係数
  • 1-オクタノール
  • 0.1mol/L酢酸塩緩衝液(pH5.2)
  • 0.0145±0.0002
  • 水(pH7.4)
  • 0.142±0.002
  • 0.1mol/Lトリス緩衝液(pH8.7)
  • 4.21±0.02 
药效药理
作用机理
利扎曲普坦作用于存在于颅内血管中的5-HT1B受体,选择性地使颅外颅内动脉收缩,据信在偏头痛发作期间颅内动脉会扩张。它也作用于三叉神经中存在的外周和中枢抑制性5-HT1D受体,阻断各种肽(P物质,降钙素基因相关肽等)的释放,引起血管舒张,硬脑膜炎和中枢疼痛。似乎抑制了传播。利扎曲普坦被认为可以通过这些作用改善偏头痛。
与5-HT1B/1D受体的选择性结合
利扎曲普坦在受体结合试验中显示出对5-HT1B和5-HT1D受体的高度亲和力,但其他5-HT受体亚型和其他受体(α和β-肾上腺素的接受)它对人体,多巴胺受体,组胺受体,毒蕈碱受体,苯并二氮杂receptor受体等(体外)显示出非常弱的亲和力。
对人类克隆5-HT1B和5-HT1D受体的作用
在与人克隆5-HT1B和5-HT1D受体的GTPγS结合测试中,利扎曲普坦具有与激动剂5-HT几乎相同的活性(体外)。
对人类切除的血管的作用
利扎曲普坦以浓度依赖的方式(10-8-10-5M)强烈收缩人切除的大脑中脑硬脑膜动脉。另一方面,它显示出对人切掉的冠状动脉的收缩力非常弱(体外)。
对麻醉动物血管床的作用
对麻醉的雪貂静脉给药(0.3-1000μg/kg)显示出剂量依赖性的颈动脉血管阻力增加,而不影响血压。另外,当对麻醉犬静脉内施用时,观察到降低颈动脉血流的作用,但是仅在300μg/kg或更高的高剂量下才观察到对冠状动脉血流的抑制作用。当对麻醉犬进行十二指肠内给药(30-1000μg/ kg)时,观察到了减少颈动脉血流的类似效果。
对硬脑膜神经元血浆蛋白泄漏的作用
当对麻醉的大鼠静脉内给药(1至1000μg/kg)时,由于三叉神经节的电刺激而导致的硬脑膜血浆蛋白渗漏以剂量依赖的方式得到抑制。
神经刺激对硬脑膜血管舒张的影响
当对麻醉的大鼠静脉内给药(1至10mg/kg)时,由于血管周围神经的电刺激而导致的硬脑膜血管的扩张被抑制在3mg/kg或更高。
电刺激硬脑膜血管(周围神经)对三叉神经核尾巴反应的影响
当对麻醉的大鼠静脉内给药(0.3至3mg/kg)时,通过硬脑膜血管(周围神经)的电刺激在三叉神经尾巴中产生活动电位的频率以1mg/kg或更高的剂量依赖性被抑制。
适应症
片头痛
用法与用量
通常,对于成年人,在偏头痛发作时口服10毫克的利扎曲普坦。如果效果不足,可以再加一次剂量,但要在前一次剂量后至少2小时离开。
但是,每日总剂量应在20mg以内。
包装

10mg
6片[6片(PTP)x 1]
18片[6片(PTP)x 3]
RPD片
10mg
6片[3片(聚丙烯盒)x 2]
18片[3片(聚丙烯盒)x 6]
制造商和分销商
吉林制药有限公司
销售
卫材有限公司
注:以上中文处方资料不够完整,使用者以原处方资料为准。
完整说明资料附件:
https://www.info.pmda.go.jp/go/pack/2160006F1026_2_13/
Maxalt RPD Tablets 10mg(Rizatriptan benzoate)
Brand name :Maxalt RPD Tablets 10mg
 Active ingredient:Rizatriptan benzoate
 Dosage form:white tablet (diameter: 12.0 to 13.8 mm, thickness: 5.1 mm)
 Print on wrapping:
マクサルトRPD錠10mg
Effects of this medicine
This medicine acts on serotonin receptors 1B in cerebral blood vessels to constrict dilated cerebral blood vessels and affects serotonin receptors 1D in the trigeminal nerve to suppress release of substances which dilates blood vessels. And it consequently relieves migraine pain.
It is usually used in the treatment of migraine.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions(itch, rach, etc.)to any medicines.
If you are a patient with myocardial infarction, ischemic heart disease, cerebrovascular disorder, transient ischemic attack, peripheral vascular disorder, hypertension or hepatic dysfunction.
If you are receiving hemodialysis.
If you are prone to epileptic seizure or convulsive seizure.
If you are taking any other medicine for migraine(Cleamine, Dihydergot, Ergometrin maleate F, Methergin, Imigran, Zomig, Relpax or Amerge).
If you are taking propranolol hydrochloride(Inderal).
If you are taking monoamine oxidase inhibitors(MAO inhibitors)or it is 14 days or less after withdrawal of it.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is (to be written by a healthcare professional)
In general, for adults, take 1 tablet (10 mg of rizatriptan) at a time, when migraine pain develops. If the effect of the medicine is insufficient, you may take another tablet after waiting for 2 hours or over from the first administration. However, the daily dosage is limited to 2 tablets (20 mg) in total. Strictly follow the instructions.
The medicine should be taken only when migraine pain develops. Do not take it to prevent migraine pain while migraine pain does not appear.
Take out the tablet from the package with dry hands immediately before taking it. Swallow it melting with saliva or with a glass of water.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
The medicine may cause drowsiness. Avoid driving a car or operating dangerous machinery after taking the medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include somnolence, malaise, weakness, nausea, vomit, dry mouth, dizziness, urticaria, rash and pruritus. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
breathing difficulty, urticaria, dizziness, cold sweat  [anaphylactic shock, anaphylaxis]
dizziness, chest pain, chest oppressing feeling  [arrhythmia, angina pectoris or ischemic heart disease-like symptoms including myocardial infarction]
convulsion, unconsciousness  [epilepsy-like seizure]
swelling of face, tongue, or throat; breathing difficulty; urticaria[angioedema]
fever, wide spread of red rash, skin peels when you rub with fingers[toxic epidermal necrosis]
shortness of breath, hard to breathe  [breathing difficulty]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep the medicine out of the reach of children. Store it away from direct sunlight, heat and moisture.
Since the medicine has hygroscopic property, do not open the package until immediately before taking it.
Do not store the remainder and ask your pharmacist or medical institution how to discard it.
Internal
Revised: 3/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.

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