部份中文左旋多巴/盐酸苄丝肼处方资料（仅供参考）
治疗类别名称
帕金森治疗药物
商標名
MADOPAR
一般名
レボドパ（Levodopa）
略名
L－ドパ（L－DOPA）
化学名
3－Hydroxy－L－tyrosine
構造式
分子式
C9H11NO4
分子量
197.19
性状
在白色或微白色晶体或与灰色彩结晶粉末，没有异味。易溶于甲酸，微溶于水，并在乙醇中（95）几乎不溶。溶于稀盐酸。饱和水溶液的pH值是5.0到6.5。
融点
約275℃（分解）
旋光度
〔α〕20D：－11.5～－13.0°（乾燥後、2.5g、1mol/L塩酸試液、50mL、100mm)
一般名
ベンセラジド塩酸塩（Benserazide Hydrochloride）
化学名
（2RS）－2－Amino－3－hydroxy－N ′－（2，3，4－trihydroxybenzyl）
propanoylhydrazide monohydrochloride
構造式
分子式
C10H15N3O5・HCl
分子量
293.70
性状
是一种白色或类白色结晶性粉末。易溶于水或甲酸，略溶于甲醇，乙醇极微溶于（95），并在乙醚中几乎不溶。水性溶液（1→100）的pH是从4.0至5.0。它是吸湿性的。光逐渐着色。水溶液（1→100）示出了没有旋光性。
组成
成分（在一个片）活性成分 - 含量
100毫克左旋多巴
苄丝肼盐酸盐28.5mg（25毫克为苄丝肼）
成分（在一个片）添加剂
乳糖水合物，玉米淀粉，羧甲纤维素钙，滑石，硬脂酸镁，号黄4（柠檬黄），红3号
适应病症
帕金森氏病，帕金森氏综合症
用法用量
未用药之前
成人：分成每日剂量1至3片第一次一至三次，饭后口服给药时，每日一次剂量为1至2片，每2至3天，并逐渐增加，31天〜作为维持剂量6锁定口服给药。
用药情况下
成人：初始每日剂量切换到左旋多巴量对应于左旋多巴量（这种药物在含有一个片剂左旋多巴100毫克）在施用大约五分之一，在1-3分剂量，饭后口服给药，逐渐增加或逐渐减小，3至6片作为维持剂量的每日剂量口服施用。
应当指出的是，增加或减少取决于患者的年龄和症状。
药效药理
左旋多巴，进入通过血脑屏障脑，通过多巴脱羧酶脱羧成为多巴胺，施加帕金森治疗作用。
盐酸苄丝肼与脱羧酶的抑制作用，不迁移到正常剂量的大脑。
代谢左旋多巴的多巴胺未在此抑制大脑，抑制多巴脱羧酶的在选择性地诺盖的动作。
通过在血液中的苄丝肼盐酸混合左旋多巴因此，儿茶酚胺（多巴胺，去甲肾上腺素等）降低，因为左旋多巴浓度增加，增加左旋多巴过渡量进入大脑，大脑多巴胺量增加。
包装　
配合錠：100錠（PTP10錠×10）、1000錠（PTP10錠×100）
制造厂商
中外制药有限公司
原处方附件：http://www.info.pmda.go.jp/go/pack/1169100F1079_1_06/
Chugai Pharmaceutical Co., Ltd.Internal
Revised: 9/2009
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name : MADOPAR Combination Tablet
　Active ingredient: Levodopa
 Benserazide hydrochloride
　Dosage form: pale red tablet (φ: approx. 9mm, thickness: approx. 3.3mm)
　Print on wrapping: マドパー配合錠
Effects of this medicine
The active ingredient of this medicine, Levodopa, changes into dopamine in the brain and improves symptoms of Parkinson disease and etc. It is usually used to treat Parkinson disease and parkinsonian syndrome.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are a patient with glaucoma, hepatic/renal disorder, diabetes, heart/lung disease, bronchial asthma, endocrine system disease, neurological manifestation such as suicide tendency, or osteomalacia.
If you have/had gastric/duodenal ulcer.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•General dosage regimen: If you have not taken Levodopa so far: For adults, take 1-3 tablet(s) in 1-3 divided doses a day, after meal on the first day. Gradually increase the dosage by 1-2 tablet(s) a day every 2-3 days. The maintenance dosage is 3-6 tablets a day. It should be adjusted according to your disease, age and symptoms. Strictly follow the instructions of your doctor/pharmacist.
If you are taking Levodopa now: For adults, take Levodopa equivalent to about 1/5 of the daily amount which you are taking (1 tablet contains 100mg of Levodopa) on the first day. Take it in 1-3 divided doses a day, after meal. Gradually increase or decrease the amount of this medicine after that. The maintenance dosage is 3-6 tablets a day. It should be adjusted according to your disease, age and symptoms. Strictly follow the instructions of your doctor/pharmacist.
•Take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose.
•If you took too much of this medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop taking this medicine without the instructions of your doctor.
Precautions while taking this medicine
•This medicine may cause sudden and temporary sleepiness, diminished attention, or decreased reflection ability. Do not drive a car, work at heights, or operate dangerous machinery.
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: involuntary movement, nausea/vomiting, loss of appetite, hallucination, sleeplessness, rash, urticaria-like eczema.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•breathlessness with fever, stiff muscles in the limbs, absent-mindedness, loss of consciousness [syndrome malin]
•hallucination, depression and indisposition, loss of appetite, lassitude, sleeplessness, impaired judgment, inability to have normal thoughts [hallucination, depression, confusion]
•bad abdominal pain, vomiting, vomiting of blood [worsening of gastric/duodenal ulcer]
•easy fatigability, anemia [hemolytic anemia]
•sudden and temporary sleepiness [sudden onset of sleep]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store at room temperature (1-30℃), away from light and moisture.
•Discard the remainder. Do not store them. Ask the pharmacist how to discard.