部份中文二甲基亚砜处方资料（仅供参考）
英文名：dimethyl sulfoxide
商品名：Rimso-50
中文名：二甲基亚砜无菌溶液
持证商：MYLAN INSTITUTIONAL INC
药品简介
RIMSO-50®是一种由50%二甲基亚砜（DMSO）和50%水组成的无菌溶液，已被美国食品和药物管理局(FDA) 批准用于缓解间质性膀胱炎患者的症状。
临床药理
二甲基亚砜在人体内通过氧化为二甲基砜或还原为二甲基硫而代谢。二甲基亚砜和二甲基砜通过尿液和粪便排泄。二甲基硫通过呼吸和皮肤排出，是服用二甲亚砜药物的患者产生特征性气味的原因。单次膀胱内灌注后，二甲基砜在血清中的持续时间可超过两周。在长期接受治疗的人类或低等动物中没有发生二甲亚砜的残留积聚。局部应用后，二甲亚砜被吸收并通常分布在组织和体液中。
适应症
RIMSO-50®（二甲亚砜）适用于缓解间质性膀胱炎患者的症状。RIMSO-50®尚未被批准为对任何其他适应症安全有效。没有临床证据表明二甲亚砜治疗尿路细菌感染有效。
剂量与用法
可通过导管或无菌注射器将50mL RIMSO-50®（二甲亚砜）直接注入膀胱，并保持15分钟。建议在插入导管之前在尿道上涂抹利多卡因凝胶等镇痛润滑凝胶，以避免痉挛。药物通过自发排尿排出。建议每两周重复一次治疗，直至症状得到最大程度的缓解。此后，可以适当地增加治疗之间的时间间隔。
在滴注RIMS-50®之前服用口服镇痛药或含有颠茄和鸦片的栓剂可以减少膀胱痉挛。
对于膀胱非常敏感的严重间质性膀胱炎患者，应在麻醉下进行初次治疗，可能还有第二次和第三次治疗（取决于患者的反应）。（建议使用鞍座）。
供货方式
小瓶中装有50毫升无菌无热原RIMSO-50®（50%w/w二甲亚砜水溶液）。
二甲亚砜清澈无色。
NDC 67457-177-50
装有50毫升小瓶的纸箱
在20°至25°C（68°至77°F）下储存。[见USP受控室温。]
请参阅随附RIMSO-50®的完整处方信息：
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=58b25d79-78f2-4953-b0c6-61658dc4ef0d
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RIMSO-50 SOL 50ML           DIMETHYL SULFOXIDE  MYLAN INSTITUTIONAL  NDC：67457017750
RIMSO-50 50% 50ML SDV 1/EA  DIMETHYL SULFOXIDE  MYLAN INSTITUTIONAL  NDC：67457-0177-50
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INFORMATION FOR PATIENTS (PHYSICIAN COPY)
RIMSO-50® is a sterile solution of 50% dimethyl sulfoxide (DMSO) and 50% water that has been approved by the U.S. Food and Drug Administration for use in the symptomatic relief of patients with interstitial cystitis.
RIMSO-50® will be instilled in the bladder on an inpatient or out-patient basis, which will be determined by your physician.
Some data indicate that dimethyl sulfoxide could change the effectiveness of medication(s) that you may be presently receiving. Be sure to mention the name and dosage of all medicines you are taking to your physician before a RIMSO-50® instillation.
A garlic-like taste may be noted by the patient within a few minutes after instillation of RIMSO-50® (dimethyl sulfoxide). This taste may last several hours. An odor on the breath and skin may be present and remain for up to 72 hours.
Some patients may experience discomfort on administration of the drug. Usually this becomes less prominent with repeated administration.
If you are pregnant or nursing, ask your physician about the advisability of using RIMSO-50®.
Some eye changes have been observed in animals treated with DMSO in large doses for prolonged periods. Therefore your doctor may want you to have eye eva luations, including slit lamp examinations prior to and periodically during treatment.