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默克首创PD-1抑制剂Keytruda(pembrolizumab)能领衔黑色素瘤市场吗?(四)
2017-09-16 06:46:27 来源: 作者: 【 】 浏览:1582次 评论:0
cisplatin, vinblastine, dacarbazine, interferon alfa, and interleukin-2 for patients with metastatic melanoma. J Clin Oncol 1998;16:1752-1759. (ii) Eton O, Legha SS, Bedikian AY, et al. Sequential biochemotherapy versus chemotherapy for metastatic melanoma: results from a phase III randomized trial. J Clin Oncol 2002;20:2045-2052. (iii) O'Day SJ, Boasberg PD, Piro L, Kristedja TS, et al. Maintenance biotherapy for metastatic melanoma with interleukin-2 and granulocyte macrophagecolony stimulating factor improves survival for patients responding to induction concurrent biochemotherapy. Clin Cancer Res. 2002(9):2775-2781. (iv) Ives NJ, Stowe RL, Lorigan P, Wheatley K. Chemotherapy compared with biochemotherapy for the treatment of metastatic melanoma: a metaanalysis of 18 trials involving 2,621 patients. J Clin Oncol 2007 25(34):5426-5434. (v) Atkins MB, Hsu J, Lee S, et al. Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): a trial coordinated by the eastern cooperative oncology group. J Clin Oncol 2008 Dec 10; 26(35):5746-5754.
13、 (i) Rao RD, Holtan SG, Ingle JN, et al. Combination of paclitaxel and carboplatin as second-line therapy for patients with metastatic melanoma. Cancer. 2006;106(2):375-382. (ii) Agarwala SS, Keilholz U, Hogg D, et al. Randomized phase III study of paclitaxel plus carboplatin with or without sorafenib as second-line treatment in patients with advanced melanoma. J Clin Oncol (Meeting Abstracts). 2007;25(18_suppl):8510. (iii) Hauschild A, Agarwala SS, Trefzer U, et al. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 2009;27:2823-2830. (iv) Flaherty KT, Lee SJ, Schuchter LM, et al. Final results of E2603: A double-blind, randomized phase III trial comparing carboplatin. (C)/paclitaxel (P) with or without sorafenib (S) in metastatic melanoma. J Clin Oncol (ASCO Meeting Abstracts) 2010. 28:(suppl; abstr):8511.

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上一篇Pembrolizumab(商品名Keytruda).. 下一篇Pembrolizumab(Keytruda®)..

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