oncentration results in activation of synthesis of gamma-butyrobetaine, which possess vasodilatating activity.Mildronate exerts cardio protective effect. In the case of chronic congestive heart failure it augments myocardial contractility, increases the tolerance of the organism to physical overload. In patients with II-III stage stable angina pectoris Mildronate increases the physical capacity and decreases the number of angina pectoris attacks.
In the cases of acute and chronic ischemic cerebrovascular disturbances Mildronate ameliorates cerebral blood flow in the ischemic region, promoting redistribution of blood flow in favour of ischemic zone.Mildronate is also characterised by a tonic effect. It prevents functional disturbances of somatic and vegetative nervous system.
Indications:
Cardiovascular diseases: chronic coronary heart disease, stable angina pectoris, chronic heart failure, functional cardiovascular disturbances, cardiomyopathy.Acute and chronic ischemic cerebrovascular disturbances.Mildronate is used also in the cases of decreased performance, physical and psycho emotional overload, and during recovery process.
Contraindications and Cautions:
Do not take Mildronate: if you are hypersensitive to Mildronate or any of the other ingredients of the medicine. You must tell your doctor before taking your medicine, if:
•you are pregnant or intend to become pregnant;
•are breast feeding.
Special care with Mildronate: Mildronate should be used with caution in patients with chronic liver or kidney diseases during long term therapy. Safety of Mildronate application in children less than 12 years age was not studied.
Pregnancy: No clinical data are available on the drug safety during pregnancy. To avoid a possible undesirable action on the organism of mother and fetus, Mildronate is not given during pregnancy.
Breast-feeding: It is not known whether active substance is excreted in human milk. If mother needs to be treated with the drug, she has to stop breast- feeding. Driving and using machines: The cases of Mildronate unfavorable effect on ability to drive or use machines are unknown.
Side Effects:
The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
In separate cases, allergic reactions, dyspeptic disturbances, tachycardia, changes in arterial pressure, headache, agitation, weakness may occur; eosinophylia has been reported (one case reported).Patients should discontinue usage of medicine and consult their doctor, if allergic reactions are developed. If you notice any side effects not mentioned in this leaflet, please inform your doctor or pharmacist. The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
Interactions:
Tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.
Mildronate could be combined with antianginal drugs, anticoagulants, antiagregants, antarrhythmic drugs, cardiac glycosides, diuretics etc.Mildronate may intensify the actions of several cardiovascular agents such as nitroglycerine, nifedipine, beta-adrenoblockers, hypotensive agents and peripheral vasodilators.
Additional:
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