个月。
【简介】
帕金森病(Parkinson disease，PD)又名震颤麻痹，是中老年人最常见的中枢神经系统变性疾病之一。世界上首个治疗帕金森病的罗替戈汀透皮贴剂由德国施瓦茨公司于2006年生产上市，商品名为neupro®。
罗替戈汀透皮贴剂是全球首个治疗PD的透皮贴剂产品，由德国施瓦茨公司(后被UCB收购)于2006年推向市场，在美国和欧洲等地的商品名为Neupro。
罗替戈汀透皮贴剂治疗帕金森病的优势：
•可连续、控制释放治疗药物，消除首过效应，提供稳态的血药浓度，避免了对多巴胺受体的脉冲式刺激，延缓神经元的变性；
•减少口服药物治疗的突然“中断”状态；
•减少服用左旋多巴等药物易引起的运动波动、开关现象等；
•增加患者的依从性和看护者的方便性。
Neupro (transdermal patch)
INDICATION
NEUPRO is a prescription medicine used to treat Parkinson's disease and moderate-to-severe primary Restless Legs Syndrome.
IMPORTANT SAFETY INFORMATION
NEUPRO contains a sulfite called sodium metabisulfite. Sulfites can cause severe allergic reactions that are life threatening to some people who are sensitive to sulfites. People with asthma are more sensitive to sulfites. Remove the patch right away and call your doctor if you have swelling of the lips or tongue, chest pain, or trouble breathing or swallowing.
NEUPRO may make you fall asleep suddenly or without warning while doing normal activities, such as driving, which may result in accidents. Tell your doctor right away if this happens. Drinking alcohol or taking other medicines that cause drowsiness may increase your chances of becoming sleepy while using NEUPRO. Do not drive, use hazardous machinery, or do other dangerous activities until you know how NEUPRO affects you.
NEUPRO can cause or worsen psychotic symptoms including hallucinations (seeing or hearing things that are not real), confusion, excessive suspicion, aggressive behavior, agitation, delusional beliefs (believing things that are not real), and disorganized thinking. The chances of having hallucinations or these other psychotic-like changes are higher in people with Parkinson's disease who are elderly, taking NEUPRO, or taking higher doses of NEUPRO. If you have any of these problems, talk to your doctor.
NEUPRO can cause decreases in blood pressure, especially when you start or increase your dose. Increases in blood pressure and heart rate, fainting, weight gain, and fluid retention also can occur. If you faint or feel dizzy, nauseated, or sweaty when you stand up from sitting or lying down, or have an unusually fast increase in weight, swelling, or fluid retention, especially in the ankles or legs, tell your doctor.
Some patients using NEUPRO get urges to behave in a way that is unusual for them, such as unusual urges to gamble, strong urges to spend money, binge eating, or increased sexual urges and behaviors. If you or your family notices you are developing any unusual behaviors, talk to your doctor.
NEUPRO may cause uncontrolled, sudden movements or make such movements you already have worse or more frequent if you have Parkinson's disease, which may mean that your anti-Parkinson's medicine needs to be changed. NEUPRO also may cause Restless Legs Syndrome symptoms to come back (rebound), become worse, or start earlier in the day.
Skin reactions may occur at the site where you apply NEUPRO. Tell your doctor if you get a rash, redness, swelling, or itching that will not go away. Some people with Parkinson's disease may have an increased chance of getting a skin cancer called melanoma. You should have your skin checked by a doctor regularly.
Avoid exposing the NEUPRO patch you are wearing to heating pads, electric blankets, heat lamps, saunas, hot tubs, heated water beds, and direct sunlight. Too m |
