部份中文左旋门冬酰胺酶处方资料（仅供参考）
英文名: L-Asparaginase
商品名：Leunase
中文名: 左旋门冬酰胺酶注射剂
生产商: 协和发酵麒麟
藥理類別：asparaginase
药理类别：抗癌药物
孕妇用药分级
C 级：
在对照的动物研究试验中显示该药学物对胚胎有不良反应（致畸胎性或杀胚胎性或其他），但未进行人体怀孕妇女研究；或者尚无对照的人体怀孕妇女或动物研究试验。只有在可能的利益大于潜在的危险，才可使用此药物。
结构式
每瓶乐拿舒注射剂含冷冻干燥之L-Asparaginase 10000ku。
UpToDate UpToDate 连结
药理作用
L-Asparaginase 因能分解血液中的L-Asparagine，使需要L-Asparagine 的癌细胞缺乏营养而达到其抗癌作用。
适应症
急性白血病(包括由慢性白血病转变成为急性者)、恶性淋巴瘤。
用法用量
一般剂量为50-200ku/kg，以静脉点滴方式投与，每日或隔日一次。剂量可依病人年龄或病情调整。
药动力学
吸收性
即时通讯
T max为14至24小时。
分配
Vd约为估计血浆体积的70％至80％。
消除
在尿液中发现微量。
IV
T½是8到30小时。
即时通讯
T½是39至49h。
副作用
1.恶心、呕吐：可使用止吐剂减轻症状。
2.过敏反应：第一次使用应做皮肤试验。
3.白血球减少、血小板减少：避免外伤、碰撞，防感染，注意营养摄取。
4.发烧：注射后2-5小时后会发烧，但可自然解热。
交互作用
甲氨蝶呤
天冬酰胺酶可能减弱或消除甲氨蝶呤对恶性细胞的作用。当天冬酰胺水平低于正常水平时，请勿将甲氨蝶呤与天冬酰胺酶一起使用或在天冬酰胺酶之后使用。天冬酰胺酶可能会增加皮质类固醇诱导的高血糖症。
长春新碱和泼尼松
静脉内给药可能与毒性增加有关。
实验室测试互动
首次给药后2天内，甲状腺素结合球蛋白的血清浓度迅速而明显地降低，可能会干扰甲状腺功能测试的解释。
药品保存方式
药品应置于摄氏2~8度冰箱内(勿冷冻)；如发生变质或过期，不可再使用。
Product Name: Loinajeju(Leunase Injection)
English ingredient name: L-Asparaginase 10000 kU
Korean ingredient name: L-asparaginase 10000 kU
Production: Production
U.S. FDA pregnancy stability: classification
Appearance: Vial containing white crystalline powder
Efficacy/Effect:
Acute and chronic leukemia, malignant lymphoma
Usage/Dosage:
Usually, 50-200 Kyu per kilogram of body weight is instilled daily or every other day.
Enemies increase or decrease depending on age and symptoms.
Precautions for use:
1. Do not administer to the following patients
1) Patients with a history of severe hypersensitivity to this drug
2. Carefully administer to the next patient
1) Patients with liver disorder
2) Patients with renal impairment
3) Patients with suppressed bone marrow function
4) Infectious disease combined patients
5) Chickenpox patients(may cause fatal systemic disorder)
3. Side effects
1) Shock: Sometimes shock symptoms may appear, so if confusion, convulsion, lower blood pressure, chills, fever, vomiting, etc. appear, stop administration immediately and take appropriate measures.
2) Hypersensitivity: A rash may appear.
3) Blood: Platelet reduction, bleeding, fibrinogen reduction, prothrombin reduction, anemia, etc. may occur.
4) Liver: Severe liver damage such as liver failure may occur. Therefore, closely observe the patient's condition such as liver function tests, and if abnormalities are found, stop administration and take appropriate measures. Liver disorder, fatty liver, and hyperammonemia may occur.
5) Kidney: Proteinuria, diuretic failure, nitremia, edema, etc. may appear.
6) Pancreas: There are cases of diabetes due to severe acute pancreatitis or pancreatic endocrine dysfunction(pancreatic langerhans adenitis). Observe carefully and take appropriate measures if abnormalities appear.
7) Brain: There are reports of death due to a wide range of brain disorders.
8) Digestive system: loss of appetite, nausea, vomiting, and diarrhea may occur.
9) Mental nervous system: Boredom, headache, sometimes drowsiness, anxiety, disorientation, consciousness disorder, coma, etc. may appear.
10) Others: Fever, vascular pain, and abnormal glucose tolerance may occur.
4. General caution
1) Since severe side effects such as bone marrow function suppression occur, frequent clinical tests (blood test, liver function, renal function test, etc.) are performed to sufficiently observe the patient's condition.If abnormalities appear, appropriate measures, such as weight reduction or suspension, are taken. If the use is continued for a long period of time, the side effects are strong, and the delay changes with time, so administration is careful.
2) Pay close attention to the onset or worsening of infectious disease and bleeding tendency.
3) When administering to children, pay special attention to side effects and administer it carefully.
4) When it is necessary to administer it to children and patients of reproductive age, consider the effect on the sex glands.
5. Administration to pregnant and lactating women
1) Since teratogenic effects have been reported in animal experiments, it is not recommended to administer it to pregnant women or pregnant women.
2) Since the safety of administration during lactation has not been established, stop lactation when administered to a nursing part.
6. Notes on application
1) Inject 0.1ml of physiological saline containing 1～10K.U. intradermally and check if there is any abnormality for 30 minutes to several hours.
2) It is used only as an instillation alcohol.
3) Use quickly after dissolution.
Storage method: sealed container, cold storage