部分中文卡铂处方资料（仅供参考）
商品名：Paraplatin injection
英文名：Carboplatin
中文名：卡铂冻干粉注射剂
生产商：施贵宝有限公司
药品简介
抗癌药Paraplatin（Carboplatin 卡铂注射液）冻干粉注射剂在日本上市，用于与其他的化疗药物组成现有的治疗方案，用于头颈癌、小细胞肺癌、睾丸癌、卵巢癌、宫颈癌、恶性淋巴瘤、非小细胞肺癌等症的初始治疗。
パラプラチン注射液50mg/パラプラチン注射液150mg/パラプラチン注射液450mg
药效分类名称
抗恶性肿瘤剂
批准日期：2006年12月
商標名
Paraplatin injection
一般名：
カルボプラチン（Carboplatin）
化学名：
（SP-4-2）-Diammine［cyclobutan-1, 1-dicarboxylato（2-）-O, O ’］platinum
構造式：
分子式：
C6H12N2O4Pt
分子量：
371.25
性状：
卡铂为白色结晶或结晶性粉末。
微溶于水，极难溶于乙醇 (99.5)。
处理注意事项
1.本品与输液混合后尽快使用。
2. 打开包装后将小瓶存放在盒子中。
3. 存放在冰箱中时可能有结晶析出。
药效药理
1.抗肿瘤作用
在小鼠中观察到对L1210白血病、P388白血病、B16黑色素瘤、colon26结肠癌、M5076卵巢癌和Lewis肺癌的抗肿瘤活性。卡铂对顺铂耐药的卵巢癌细胞系KFr和TYK-nu(R)细胞具有交叉耐药性，但程度是顺铂的1/2或1/4。
2. 作用机制
人们认为它与癌细胞中的DNA链结合并抑制DNA合成和随后的癌细胞分裂。
适应症
头颈癌、小细胞肺癌、睾丸肿瘤、卵巢癌、宫颈癌、恶性淋巴瘤、非小细胞肺癌、乳腺癌与其他抗肿瘤药物联合治疗以下恶性肿瘤
小儿恶性实体瘤（神经母细胞瘤、视网膜母细胞瘤、肝母细胞瘤、中枢神经系统生殖细胞瘤、复发或难治性尤文氏肉瘤家族肿瘤、肾母细胞瘤）
用法与用量
1.用于头颈癌、小细胞肺癌、睾丸癌、卵巢癌、宫颈癌、恶性淋巴瘤、非小细胞肺癌
卡铂成人常用剂量为300～400mg/m2（体表面积），每日一次，停药至少4周。这是一个疗程，重复给药。剂量应根据患者的年龄、疾病和症状进行调整。
2. 用于乳腺癌
与曲妥珠单抗（基因重组）和紫杉烷类抗肿瘤药联合使用，卡铂成人常用剂量为300～400mg/m2（体表面积），每日一次，停药至少3周。这是一个疗程，重复给药。应根据患者的情况调整剂量。
3. 与其他抗肿瘤药物同时用于小儿恶性实体瘤（神经母细胞瘤、视网膜母细胞瘤、肝母细胞瘤、中枢神经系统生殖细胞瘤、复发或难治性尤文肉瘤家族肿瘤、肾母细胞瘤）的治疗情况下
(1) 与其他抗肿瘤药物联合治疗神经母细胞瘤/肝母细胞瘤/中枢神经系统生殖细胞瘤、复发或难治性尤文氏肉瘤家族肿瘤/肾母细胞瘤的情况在异环磷酰胺和依托泊苷的联合治疗中，卡铂的剂量和给药方法为卡铂635mg/m2（体表面积）1天或400mg/m2（体表面积）2天，至少。停药3-4周。这是一个疗程，重复给药。
可根据疾病、症状及其他抗肿瘤药物联合使用，适当减少给药剂量和给药天数。此外，1岁以下或体重10公斤以下儿童的用量要适当考虑。
(2) 与其他抗肿瘤药物联合治疗视网膜母细胞瘤的情况
在硫酸长春新碱与依托泊苷联合治疗中，卡铂的剂量和给药方法为560mg/m2（体表面积）为卡铂静脉滴注1天，停药至少3～4周。这是一个疗程，重复给药。但是，对于36个月以下的儿童，卡铂应该是18.6mg/kg。可根据疾病、症状及其他抗肿瘤药物联合使用，适当减少给药剂量和给药天数。
4.本品给药时，视剂量与葡萄糖注射液或生理盐水250mL以上混合，静脉滴注30分钟以上。
包装
注射液
50毫克： 5毫升（含50毫克卡铂）1瓶
150毫克：15毫升（含150mg卡铂）1小瓶
450毫克：45毫升（含450mg卡铂）1小瓶
制造商和分销商
百时美施贵宝有限公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明附件：
https://www.info.pmda.go.jp/go/pack/4291403A1088_1_12/
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PARAPLATIN INJECTION 50mg（パラプラチン注射液50mg） 
Brand name : PARAPLATIN INJECTION 50mg
　Active ingredient: Carboplatin
　Dosage form: injection
　Print on wrapping: 
Effects of this medicine
This medicine inhibits growth of cancer cells at a cell division level and destroy the cells.
It is usually used to treat head and neck cancer, small cell lung cancer, testicular tumor, ovarian tumor, uterine cervical cancer, malignant lymphoma, non-small cell lung cancer, breast cancer and pediatric malignant solid tumor (neuroblastoma, retinoblastoma, hepatoblastoma, central nervous system germ cell tumor, recurrent/refractory Ewing's sarcoma family of tumor, nephroblastoma).
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have impaired renal/hepatic function, low level of white blood cells or other blood components, fever or chicken pox.
•If you are pregnant, possibly pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, repeat the cycle of administering once a day or 2 days with a drug cessation period of 3 to 4 weeks.
•It may be administered over a long period according to your response to the treatment.
•In order to prevent nausea, medicines for nausea may be used in advance.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include nausea/vomiting, loss of appetite, hives, loss of hair, general malaise, fever, diarrhea, stomatitis, stomachache, constipation, rash, urine with blood, protein urea, edema, chill, dehydration, weight loss, respiratory distress, peripheral neuropathy and headache. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•fever, chill, cough, nasal discharge, dizziness, bleeding tendency, continuous bleeding, bruise, dullness, easy fatigability, shortness of breath, sore throat [myelosuppression such as pancytopenic]
•lips/nails turning bluish-purple, breathing difficulty/chest tightness, suddenly feeling unwell, dizziness [shock, anaphylaxy]
•fever, cough, breathing difficulty/chest tightness [interstitial pulmonary disease]
•inability to pass urine, urine with blood [acute renal failure]
•jaundice [hepatic failure, hepatic function disorder, jaundice]
•severe stomachache, hematoma [gastrointestinal necrosis, gastrointestinal perforation, gastrointestinal bleeding, gastrointestinal ulceration]
•severe stomachache, diarrhea [hemorrhagic enteritis, pseudomembranous colitis]
•loss of appetite, nausea/vomiting, severe constipation, stomachache, abdominal distention, retention of bowel contents [paralytic ileus]
•decreased consciousness, numbness of limbs, breathing difficulty [cerebral infraction, lung infraction]
•numbness of limbs, breathing difficulty [thrombosis/embolism]
•palpitation, shortness of breath, chest pain, breathing difficulty [myocardial infarction, congestive heart failure]
•bleeding tendency, continuous bleeding, failure of urinating, yellowness in the skin or whites of the eyes, dizziness, purple spots in the skin [hemolytic-uremic syndrome]
•sudden respiratory distress [acute respiratory distress syndrome]
•bleeding tendency, continuous bleeding [disseminated intravascular coagulation]
•severe upper abdominal pain [acute pancreatitis]
•hearing loss [hearing impairment]
•unstableness while walking, speech disorder, memory loss, slow movement [leukoencephalopathy (reversible posterior leukoencephalopathy)]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Bristol-Myers SquibbInjection
Revised: 8/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.