部份中文洛度沙胺氨丁三醇处方资料（仅供参考）
英文名: lodoxamide tromethamine
商品名：Alomide ophthalmic solution 0.1％
中文名: 洛度沙胺氨丁三醇滴眼液
生产商: 爱尔康
药品简介 Alomide（Lodoxamide Tromethamine ophthalmic solution 0.1％ 中文译名：洛度沙胺氨丁三醇）滴眼液为一新合成的药品，具有抑制肥大细胞去颗粒作用及嗜伊红白血球趋化作用之双重效能。用于治疗春季角膜结膜炎，春季结膜炎和春季角膜炎。
临床药理：
Lodoxamide tromethamine是肥大细胞稳定剂，可抑制体内I型立即超敏反应。罗多沙酰胺疗法抑制与血管生成素或IgE和抗原介导的反应有关的皮肤血管通透性增加。
体外研究表明，洛多沙胺具有稳定啮齿动物肥大细胞和防止抗原刺激的组胺释放的能力。另外，碘代乙酰胺防止其他肥大细胞炎性介质（即SRS-A，过敏反应的慢反应性物质，也称为肽-白三烯）的释放并抑制嗜酸性粒细胞的趋化性。尽管洛多沙酰胺的确切作用机理尚不清楚，但据报道该药物可在抗原刺激下阻止钙流入肥大细胞。
Lodoxamide没有固有的血管收缩剂，抗组胺药，环氧合酶抑制作用或其他抗炎活性。
在接受3mg（50μCi）口服洛多沙胺剂量的六名健康成人志愿者中研究了14C-洛多沙胺的处置。尿排泄是消除的主要途径。尿液中14 C-碘氧酰胺的消除半衰期为8.5小时。在一项针对十二名健康成人志愿者的研究中，局部施用0.1％的ALOMIDE®（碘乙酰胺三甲胺）滴眼液，每天四次，每只眼一滴，持续10天，在检测限内未导致任何可测量的洛多沙胺血浆水平2.5ng/mL。
适应症和用途：
0.1％ALOMIDE（洛度沙胺氨丁三醇）眼药水可用于治疗眼部疾病，这些疾病被称为春季角膜结膜炎，春季结膜炎和春季角膜炎。
用法用量：
成人和2岁以上儿童的剂量为每只受影响的眼睛1-2滴，每天四次，最多3个月。
禁忌症：
对本产品的任何成分过敏。
包装供应方式：
0.1％的ALOMIDE®（洛度沙胺氨丁三醇胺滴眼液）通过塑料滴眼剂DROP-TAINER®分配器提供，如下所示：
10毫升NDC 0065-0345-10
储存：存放在15°C至27°C（59°F-80°F）
ALOMIDE 0.1% DRP 10ML LODOXAMIDE TROMETHAMINE ALCON LABS NDC：65034510
完整说明资料附件： https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1b97597f-f2e7-4574-81a8-f35b769c957a
ALOMIDE(lodoxamide tromethamine ophthalmic solution)0.1%
This medication is used to treat certain allergic eye conditions (vernal keratoconjunctivitis, vernal conjunctivitis, vernal keratitis). It prevents itching of the eyes that can occur with these conditions. Lodoxamide is known as a mast cell stabilizer. It works by blocking certain natural substances (histamine, leukotriene) that cause allergic symptoms.
How to use Alomide Drops
To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.
It is best to not wear contact lenses while using this medication.
This medication is used in the affected eye(s), usually 4 times daily or as directed by your doctor. Treatment may be continued for as long as 3 months.
Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over the eye and place 1 drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of the eye near the nose and apply gentle pressure. This will prevent the medication from draining away from the eye. Try not to blink and do not rub the eye. Repeat these steps if your dose is for more than 1 drop and for the other eye if so directed.
Do not rinse the dropper. Replace the dropper cap tightly after each use.
If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.
Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Continue using it for the full time prescribed.
It may take up to several days of continued use to see a relief in symptoms. If immediate relief of symptoms (itching) is needed, use other quick-relief medication (such as eye drops containing antihistamines, decongestants, or nonsteroidal anti-inflammatory drugs-NSAIDs) along with lodoxamide as directed by your doctor. Tell your doctor if your condition persists or worsens.
