枸橼酸钠注射液 Citra-Lock 46.7% Kath-Blocklsg. Ampullen - 参比剂新闻

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枸橼酸钠注射液 Citra-Lock 46.7% Kath-Blocklsg. Ampullen

2014-04-22 12:02:34 来源: 作者: 【大中小】浏览:3452次评论:0条

Citra-Lock™ 46,7%

the effective concentrations

Using Citra-Lock™ 46,7% :

improves overall patency rates
reduces catheter-related infections
reduces major bleeding for both tunneled an untunneld Central Venous Catheters (CVC)

Anti Microbial

cl3046 afb 1

Superior antimicrobial activity of trisodium citrate over heparin for catheter locking, Marcel C. Weijmer et al, Nephrol Dial Transport (2002) 17: 2189-2195

Since the introduction of Citra-Lock™ (46,7%) to the renal departmant of St.Bard's renal unit (Royal London Hospital) has proven record in managing MRSA.

The number of MRSA infections has fallen from 2,27/1000 patiens catheter days to 1,36/1000 patiens catheter days.

Citra-Lock™ intervention provides significant benefit to patiens, provides an extra 2-3 bed days to the hospital an provides savings of € 145.000,- .

Nolan JP, reducing Catheter Related Bacteraemia in Haemodialysis. Vascular Access Soc. 5th Int. Congress of Vascular Access Soc, Nice, 2007

Anti Coagulant

1. Ash SR (2000) Concentrated Sodium Citrate (23%) for Catheter Lock. Haemodialysis International 4:22-31

Citra-Lock™ is based on higly concentrated trisodium citrate that prevents clotting and therefore helps maintaining high flow rates whilst greatly reducing the need for Urokinase/tPA and otheter replacements.

Anti Biofilm

Trisodium citrate (TSC) lowers infection rates by reducing biofilm formation in hemodialysis catheters. The study of Bosma (2009) demonstrates an in vivo reduction of intraluminal catheter biofilm formation and bacterial colonizasion with the use of TSC 30% for HD catheter locking. By this mechanism, prevention of catheter-related infections by TSC can be largely explained.

Increase Safety & Simplified handling

The Citra-Lock™ vial features a drip free Luer-Slip/Luer-Lock connector: luer slip lock

preventing microbial contamination
protecting against needle stick injuries
reducing handling steps
promoting intuitive handing

Box 46

Download References / Publications Citra-Lock™

Citra-Lock™ 46,7% 5ml vial

Boxes contain 20 x 5ml vial

Art.nr. 24060202

Œ1275

Citra-Lock^TM is trisodium citrate solution for catheter locking available from Renalfarma in following concentrations:

Citra-Lock^TM 4% 5ml vial

Citra-Lock^TM 30% 5ml vial

Citra-Lock^TM 46,7% 5ml vial

CitraFlow^TM 4% prefilled syringe 2,5ml

In addition to anti-clotting effect Citra-Lock^TM provides anti-microbial and anti-biofilm protection and does not have heparin side effects.

Citra-Lock^TM and Citra-Flow^TM are registered as a medical device (Class IIb)

New European Guidelines Catheter Lock Solution

In the June edition of NDTplus the new European recommendation of preventing heamodialysis catheters by ERBP is published.
ERBP ( European Renal Best Practice) is the new guidance body of the European Renal Association-European Dialysis and Transplantation Association (ERA-EDTA).

The ERBP recommends to use Citrate lock of minimal 4% as the catheter lock solution instead of heparin.

'The clinical advantages offered by citrate have been
confirmed in at least two meta-analyses Over
time, progressively lower concentrations of citrate have
been applied (from 46.7% to 4%) with still significantly
better results, even in the latter case, than those obtained with heparin locks¹' .

1. Vanholder et al, Diagnosis, prevention and treatment of haemodialysis catheter-related blood stream infections (CRBSI), a position statement of European Renal Best Practice (ERBP). NDTplus June 2010

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