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See related Remicade infusion information |
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Manufacturer |
MSD |
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Distributor |
Zuellig |
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Contents |
Infliximab |
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Indications |
Listed in Dosage.
Click to view Remicade detailed prescribing infomation |
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Dosage |
RA Initially 3 mg/kg IV infusion over 2 hr followed w/ 3 mg/kg administered 2 & 6 wk after 1st infusion then every 8 wk thereafter. After 22 wk, may be increased up to 5-10 mg/kg every 8 wk if necessary. Should be given in combination w/ methotrexate. Moderate to severe Crohn's disease Induction regimen: 5 mg/kg as single IV infusion over 2 hr at 0, 2 & 6 wk. Maintenance regimen: 5 mg/kg every 8 wk thereafter. Pediatric Crohn's disease 5 mg/kg as IV infusion followed by additional 5 mg/kg infusion doses at 2 & 6 wk after the 1st infusion then every 8 wk thereafter. In incomplete response, dose may be adjusted up to 10 mg/kg. Ankylosing spondylitis 5 mg/kg IV infusion over 2 hr followed by 5 mg/kg doses administered at 2 & 6 wk after 1st infusion then every 6-8 wk thereafter. Psoriasis, psoriatic arthritis, ulcerative colitis 5 mg/kg IV infusion over 2 hr followed by additional 5 mg/kg infusion at 2 & 6 wk after the 1st infusion then every 8 wk thereafter. Re-administration for Crohn's disease & RA May be re-administered w/in 16 wk following last infusion if signs & symptoms recur. Fistulizing Crohn's disease 5 mg/kg IV infusion over 2 hr followed w/ 5 mg/kg dose at wk 2 & 6 after 1st infusion. Maintenance: 5 mg/kg every 8 wk if the patient responds after these 3 doses.
Click to view Remicade detailed prescribing infomation |
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Overdosage |
View Remicade overdosage for action to be taken in the event of an overdose. |
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Contraindications |
Sensitivity to murine proteins. TB, sepsis, abscesses, opportunistic infections. Moderate to severe heart failure (NYHA class III/IV).
Click to view Remicade detailed prescribing infomation |
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Special Precautions |
Monitor patients for at least 1 hr post-infusion for acute infusion effects & delayed hypersensitivity reactions. eva luate patients for infections prior to therapy. Clinically manifested infections &/or abscesses. Lupus-like syndrome (discontinue treatment). Elderly. Liver or renal impairment. Childn. Pregnancy & lactation.
Click to view Remicade detailed prescribing infomation |
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Adverse Drug Reactions |
Viral infection, fever, serum sickness-like reactions, headache, vertigo/dizziness, flushing, upper & lower resp tract infection, dyspnea, sinusitis, GI disturbances, abnormal hepatic function, rash, pruritus, urticaria, increased sweating, dry skin, fatigue, chest pain, infusion-related reactions.
View ADR Monitoring Form |
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Drug Interactions |
Formation of antibodies to infliximab reduced w/ methotrexate & other immunomodulators. Combination w/ anakinra is not recommended.
View more drug interactions with Remicade |
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Pregnancy Category (US FDA) |
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). |
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Storage |
View Remicade storage conditions for details to ensure optimal shelf-life. |
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Mechanism of Action |
View Remicade mechanism of action for pharmacodynamics and pharmacokinetics details. |
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Presentation/Packing |
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Form |
Packing |
Photo |
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Remicade infusion |
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Remicade 100 mg x 1's |
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Manufacturer: |
MSD |
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Distributor: |
Zuellig |
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