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See related Lipitor tab information |
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Manufacturer |
Pfizer |
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Distributor |
Zuellig |
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Contents |
Atorvastatin Ca |
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Indications |
Adjunct to diet to reduce elevated total-cholesterol, LDL-cholesterol, apolipoprotein B & triglycerides levels. Increase HDL-cholesterol in patient w/ primary hypercholesterolemia, combined (mixed) hyperlipidemia, hypertriglyceridemia & dysbetalipoproteinemia who do not respond adequately to diet. Reduction of total-cholesterol & LDL-cholesterol in patient w/ homozygous familial hypercholesterolemia when response to diet & other nonpharmacological measures are inadequate. Adjunct to diet to reduce total-cholesterol, LDL-cholesterol & apolipoprotein B levels in boys & postmenarchal girls 10-17 yr w/ heterozygous familial hypercholesterolemia if after an adequate trial of diet therapy, LDL-cholesterol remain ≥190 mg/dL. Prevention of CV complications in patients w/ or w/o clinically evident CV disease &/or dyslipidemia but w/ ≥3 risk factors for CHD, through reduction of risk of: Fatal CHD & nonfatal MI; stroke; & revascularization procedures & angina pectoris. Patients w/ clinically evident CHD, reduce risk of: Nonfatal MI, fatal & nonfatal stroke, revascularization procedures, hospitalization for CHF, angina.
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Dosage |
10-80 mg once daily. Starting & maintenance dose individualized according to baseline LDL-cholesterol levels, goal of therapy & patient response. Childn 10-17 yr Initially 10 mg/day. Max: 20 mg/day.
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Overdosage |
View Lipitor overdosage for action to be taken in the event of an overdose. |
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Administration |
May be taken with or without food |
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Contraindications |
Active liver disease or unexplained persistent elevation of serum transaminases exceeding 3 times the upper limit of normal. Pregnancy, lactation or women of childbearing potential not using adequate contraceptive measures.
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Warnings |
For additional cautionary notes to warn of the potential risk of using the medicine... click to view Lipitor detailed prescribing infomation |
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Special Precautions |
May cause creatine phosphokinase & transaminase elevations. Avoid alcohol consumption. Report promptly unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever.
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Adverse Drug Reactions |
Constipation, flatulence, dyspepsia, abdominal pain, headache, nausea, myalgia, asthenia, diarrhea & insomnia. Rare adverse events: Rhabdomyolysis, allergic reactions (including anaphylaxis & urticaria), thrombocytopenia.
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Drug Interactions |
Risk of myopathy increased w/ concurrent administration of cyclosporin, fibric acid derivatives, erythromycin, niacin or azole antifungals. Decreased atorvastatin plasma conc w/ oral antacid suspensions containing Mg & Al hydroxides, & colestipol. Increases steady-state plasma digoxin conc. Increased atorvastatin plasma conc w/ erythromycin. Increases AUC values for norethindrone & ethinylestradiol.
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Pregnancy Category (US FDA) |
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant. |
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Storage |
View Lipitor storage conditions for details to ensure optimal shelf-life. |
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Description |
View Lipitor description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Lipitor mechanism of action for pharmacodynamics and pharmacokinetics details. |
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