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Manufacturer Novartis 
Distributor Zuellig 
Contents Zoledronic acid
Indications Treatment of osteolytic, osteoblastic & mixed bone metastases of solid tumors & osteolytic lesions of multiple myeloma in conjunction w/ standard antineoplastic therapy. Reduction of bone damage in patients w/ advanced malignancies involving bone. Treatment of hypercalcaemia of malignancy (HCM).
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Dosage IV infusion of no <15 min Adult & elderly Treatment of bone mestastases & osteolytic lesions & reduction of bone damage in patients w/ advanced malignancies involving bone 4 mg every 3-4 wk. Administer oral Ca supplement of 500 mg & vit D 400 IU daily. Treatment of HCM 4 mg.
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Overdosage View Zometa overdosage for action to be taken in the event of an overdose.
Contraindications Hypersensitivity to bisphosphonates. Pregnancy & lactation.
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Special Precautions Severe renal or hepatic impairment. Monitor serum Ca, phosphate, Mg & creatinine. Ensure adequate hydration. Avoid invasive dental procedures in patients w/ concomitant risk factors (eg cancer, chemotherapy, corticosteroids, poor oral hygiene) due to risk of osteonecrosis of the jaw.
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Adverse Drug Reactions Anemia, headache, conjunctivitis, nausea, vomiting, anorexia, bone pain, myalgia, arthalgia, generalized pain, renal impairment, fever, flu-like syndrome, hypophosphatemia, increased blood creatinine & blood urea, hypocalcemia, local infusion site reactions, osteonecrosis of the jaw.
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Drug Interactions Aminoglycosides, other potentially nephrotoxic drugs, thalidomide.
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Pregnancy Category (US FDA)      
     
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). 
Caution For Usage For caution against possible variation of physical aspect of medicine... click to view Zometa detailed prescribing infomation
Storage View Zometa storage conditions for details to ensure optimal shelf-life.
Description View Zometa description for details of the chemical structure and excipients (inactive components).
Mechanism of Action View Zometa mechanism of action for pharmacodynamics and pharmacokinetics details.

Presentation/Packing
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Zometa infusion  Zometa 4 mg/5 mL x 1's 
 
Manufacturer: Novartis
 
Distributor: Zuellig