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See related Zyvox information |
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Manufacturer |
Pfizer |
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Distributor |
Zuellig |
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Contents |
Linezolid |
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Indications |
Gm +ve bacteria only, vancomycin-resistant Enterococcus faecium infections, nosocomial pneumonia caused by Staph aureus (methicillin-susceptible & -resistant strains) or Strep pneumoniae (including multi-drug-resistant strains [MDRSP]). Complicated skin & skin structure infections including diabetic foot infections w/o concomitant osteomyelitis caused by Staph aureus (methicillin-susceptible & -resistant strains), Strep pyogenes or Strep agalactiae. Uncomplicated skin & skin structure infections caused by Staph aureus (methicillin-susceptible only) or Strep pyogenes. Community-acquired pneumonia caused by Strep pneumoniae (including MDRSP) including cases w/ concurrent bacteremia or Staph aureus (methicillin-susceptible only). |
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Dosage |
Adult Tab/IV 600 mg 12 hrly. Complicated skin & skin structure infections, community-acquired pneumonia including concurrent bacteremia, nosocomial pneumonia 10-14 days. Vancomycin-resistant Enterococcus faecium infections including concurrent bacteremia 14-28 days. Uncomplicated skin & skin structure infections 10-14 days. IV Administer by IV infusion over a period of 30-120 min. |
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Administration |
May be taken with or without food |
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Contraindications |
Hypersensitivity. Concomitant MAOIs, directly & indirectly acting sympathomimetics (eg pseudoephedrine, phenylpropanolamine), vasopressive agents (eg epinephrine, norepinephrine), dopaminergic agents (eg dopamine, dobutamine), serotonin re-uptake inhibitors, TCAs, serotonin 5-HT1 receptor agonists (triptans), meperidine, buspirone. |
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Special Precautions |
Lactic acidosis. If recurrent nausea or vomiting, unexplained acidosis or low bicarbonate level develop during therapy, perform immediate medical eva luation. Peripheral neuropathy & optic neuropathy if duration of treatment exceeds 28 days. |
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Adverse Drug Reactions |
Diarrhea, headache, nausea.
View ADR Monitoring Form |
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Pregnancy Category (US FDA) |
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus. |
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Presentation/Packing |
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Form |
Packing |
Photo |
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Zyvox film-coated tablet |
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Zyvox 600 mg x 10's |
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Zyvox infusion |
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Zyvox 2 mg/1 mL x 300 mL x 1's |
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Manufacturer: |
Pfizer |
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Distributor: |
Zuellig |
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