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See related Caduet information |
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Manufacturer |
Pfizer |
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Distributor |
Zuellig |
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Contents |
Amlodipine besylate, atorvastatin Ca. |
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Indications |
Patients at increased CV risk due to the presence of 2 modifiable risk factors HTN & dyslipidemia; &/or chronic stable angina. Prevention of CV complications in hypertensive patients.
Click to view Caduet detailed prescribing infomation |
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Dosage |
Dosage range of amlodipine/atorvastatin: 5 mg/10 mg to a max dose of 10 mg/80 mg once daily.
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Overdosage |
View Caduet overdosage for action to be taken in the event of an overdose. |
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Administration |
May be taken with or without food |
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Contraindications |
Active liver disease or unexplained persistent elevations of serum transaminases >3x the upper limit of normal. Pregnancy, lactation or women of childbearing potential who are not using adequate contraceptive measures.
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Warnings |
For additional cautionary notes to warn of the potential risk of using the medicine... click to view Caduet detailed prescribing infomation |
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Special Precautions |
Heart failure, impaired hepatic function. Perform liver function tests before initiating treatment & periodically thereafter. Patient who consume substantial quantities of alcohol &/or have a history of liver disease. Discontinue drug if markedly elevated creatinine phosphokinase levels occur or myopathy is diagnosed or suspected. Acute, serious condition suggestive of myopathy or risk factor predisposing to development of renal failure secondary to rhabdomyolysis.
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Adverse Drug Reactions |
Amlodipine: Flushing, fatigue, edema, dizziness, headache, abdominal pain, nausea, palpitations, somnolence. Atorvastatin: Insomnia, headache, GI disturbances, myalgia, asthenia.
View ADR Monitoring Form |
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Drug Interactions |
Digoxin, erythromycin/clarithromycin, protease inhibitors, diltiazem HCl, itraconazole, grapefruit juice, colestipol, OC containing norethindrone & ethinyl estradiol. CYP3A4 inhibitors & inducers. Grapefruit juice.
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Pregnancy Category (US FDA) |
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant. |
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Storage |
View Caduet storage conditions for details to ensure optimal shelf-life. |
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Description |
View Caduet description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Caduet mechanism of action for pharmacodynamics and pharmacokinetics details. |
