部份中文阿利吉仑处方资料（仅供参考）
用途及特色
阿利吉仑是一種新式的降血壓藥物，透過壓抑血液中腎素（Renin）的活動去減低血管緊張素（Angiotensin）的形成，從而降低患者的血壓。阿利吉仑可单用于治疗，或配合其他降血压药物使用。
注册品牌名称:阿利吉仑在香港的已注册品牌名称为Rasilez ® 。
此外，阿利吉仑于美国食物及药物管理局（FDA）注册时，使用的品牌名称为Tekturna 。
剂型阿利吉仑为药丸，按照剂量分别有两种颜色： 150毫克 - 浅粉红色，药丸上面印有IL字样 300毫克 - 淡红色，药丸上面印有IU的字样
以下情况忌用此药物：现正服用环孢素现正怀孕，计划怀孕或正在哺乳的妇女对药物当中任何成份敏感留意事项在怀孕期间服用阿利吉仑可对胎儿造成伤害，甚至引致胎儿死亡。如在用药期间怀孕，请联络您的医生安排停药。开始服用阿利吉仑的初期，有可能出现严重晕眩，甚至昏厥等血压过低的症状。若果情况发生，请让病者躺下稍事休息，如没有好转，请即送院。请将阿利吉仑存放于室温阴凉处。药物无需冷藏。请将药物贮存于原来的药瓶内，不要移走瓶内的防潮剂。请将药物放在儿童不能触及的地方。
药物常见副作用。由阿利吉仑引致的副作用相对较少使用正常剂量时，常见的副作用包括：腹痛，恶心，腹泻头痛，晕眩出疹，咳嗽如果副作用持续，或者出现严重副作用，例如：面部，嘴唇，喉咙，舌头肿胀呼吸或吞咽困难血压过低的症状，例如严重晕眩，甚至昏厥请即通知您的医生。
与其他药物相互作用阿利吉仑与不少药物均可能产生相互作用，当中包括：免疫系统抑制剂环孢素抗真菌药物酮康唑其他降血压药物，包括：利尿药 -呋塞米和氢氯噻嗪血管紧张素转化酵素抑制药（ ACE抑制剂） - 雷米普利血管紧张素受体阻断剂（ ARB ） - 厄贝沙坦和缬沙坦钙离子通道阻断剂 - 氨氯地平降胆固醇药阿托伐他汀此外，暂未有研究对阿利吉仑与其他食物或草药的相互作用进行研究。因此，服用阿利吉仑的病者在购买其他药物及保健食品前，请先咨询医生或药剂师的意见。
用药时间请于每日同一时间服用阿利吉仑。餐前或餐后用药均可。

How does it work?
Rasilez tablets
contain the active ingredient aliskiren, which is a type of medicine called a renin inhibitor. It is used to help lower high blood pressure. Aliskiren works by preventing the action of an enzyme in the body called renin. Normally renin is involved in the production of another compound called angiotensin I, which in turn is converted to angiotensin II as part of the body's natural control of blood pressure. Angiotensin II causes blood vessels to constrict and narrow, which increases the pressure within the blood vessels. By blocking the action of renin, aliskiren reduces the production of angiotensin I and II.
This means that the blood vessels are allowed to relax and widen.
The overall effect of this is a drop in blood pressure, hence aliskiren can be used to lower high blood pressure.
What is it used for? High blood pressure with no known cause (essential hypertension). How do I take it? Rasilez tablets should be taken once a day.
The dose prescribed depends on how well your blood pressure is controlled. Follow the instructions given by your doctor.
It is recommended that your Rasilez tablet is taken at the same time each day with a light meal. Meals with a high fat content can reduce the absorption of this medicine from the gut. Swallow the tablet with a drink of water. Do not take this medicine with grapefruit juice, because this can reduce the absorption of the medicine into the blood. If you forget to take a dose at your usual time take it as soon as you remember, unless it is nearly time for
your next dose. In this case, just leave out the forgotten dose and take your next scheduled dose as normal. Do not take a double dose to make up for a missed dose. Warning!
Blood pressure lowering medicines such as this one can sometimes make you feel dizzy or weary. If affected you should avoid performing potentially hazardous tasks such as driving or operating machinery. If you feel dizzy this can usually be relieved by lying down until the symptoms pass. Any dizziness may be made worse by drinking alcohol. If you frequently feel dizzy you should let your doctor know, as your dose of this medicine may need adjusting.
The most common side effect associated with this medicine is diarrhoea. If you experience diarrhoea that becomes severe or doesn’t go away you should consult your doctor.
Your blood pressure, kidney function and the amount of potassium in your blood should be regularly monitored while you are taking this medicine.
This medicine may rarely cause an allergic reaction called angioedema. Stop taking this medicine and consult your doctor immediately if you experience difficulty breathing or swallowing, or swelling of your face, lips, tongue, throat, hands, feet or ankles while taking this medicine. Use with caution in Heart disease, such as heart failure. Kidney disease or decreased kidney function.
People with narrowing of the arteries that supply blood to the kidneys (renal artery stenosis). Liver disease. Diabetes. People with low salt or fluid volume in the body, eg due to high-dose diuretic therapy, low-salt diet, or severe blood loss, diarrhoea, vomiting or dehydration. People with a history of allergies, particularly allergic reactions involving swelling of the lips, face or tongue (angioedema). Not to be used in People with a history of swelling of the lips, face or tongue (angioedema) with no known cause, or caused by previous use of aliskiren. Hereditary angioedema(angioneurotic oedema). People with diabetes or reduced kidney function who are also taking an ACE inhibitor or angiotensin receptor blocker medicine. People with severely decreased kidney function. Pregnancy. Breastfeeding. This medicine is not recommended for children and adolescents under 18 years of age because it has not been studied in this age group.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. Pregnancy and breastfeeding Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby.
Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine. The safety of this medicine for use during pregnancy has not been established, however there is potential that it could be harmful to a developing baby.
It should not be used during pregnancy, in particular during the second and third trimesters. If you get pregnant while taking this medicine you should stop taking it and seek medical advice from your doctor.
It is not known if this medicine passes into breast milk. The manufacturer states that it is not recommended for women who are breastfeeding. Seek further medical advice from your doctor. Side effects Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
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