部份中文盐酸奥普力农处方资料（仅供参考）
英文名：Carperitide(Genetical Recombination)
商品名：HANP FOR INJECTION
中文名：卡哌利汀注射液
生产商：第一三共制药
ハンプ注射用1000
药物类别名称
α型人心房内尿多肽配方
批准日期：1995年3月
商標名
HANP FOR INJECTION
一般名
カルペリチド(遺伝子組換え)
Carperitide(Genetical Recombination)
分子式
C127H203N45O39S3
分子量
3080.44
構造式
28個のアミノ酸残基からなるペプチド
性状
它是白色粉末或质量。 易溶于水或稀释醋酸,不易在甲醇中轻微溶解,难以溶于乙醇(95)。
药用药理学
对血管的影响
以浓度依赖性的方式放松了狗的切除和静脉血管条,在运动和静脉的肺血管中强烈观察到这种作用。
对肾脏的影响
狗的肾血流量,通过增加肾小球过滤率,增加尿液和尿液中钠排泄量。
对内分泌系统的影响
有一种趋势,抑制在大鼠肾切片标本中异丙酮醇的分泌。
抑制牛肾上腺皮层球面无球层细胞标本中血管紧张素II的分泌。
对实验性心力衰竭的影响
冠状动脉结扎,电容负荷,在低节拍急性心力衰竭模型狗准备与盐酸丙醇和盐酸甲胺,降低平均肺动脉压力和全身血管阻力,通过增加心脏输出, 急性心力衰竭期间的流体动力学得到改善。
作用机制
结合β型人心房利尿钠多肽的受体,通过激活膜结合的冠酸环酶、血管扩张剂来增加细胞中的cGMP,相信能表达利尿作用等。
适应症
急性心力衰竭(包括慢性心力衰竭的急性恶化)
用法与用量
急性心力衰竭(包括慢性心力衰竭的急性恶化)
该剂溶解于日本药典注射水中5mL,稀释与日本药典盐水溶液或5%葡萄糖注射液(如有必要)一样,每分钟作为卡佩里德连续静脉注射。虽然在监测流感动力学时适当调整剂量,但根据患者情况,剂量可增加到每分钟0.2μg /kg。
包装
注射用
1000：10小瓶
制造和销售
第一三共株式会社
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：
https://www.kegg.jp/medicus-bin/japic_med_product?id=00008757
HANP Injection 1000
HANP Injection 1000 is a freeze-dried pharmaceutical used to treat acute heart failure. Originally launched in 1995, this product initially had to be stored at below 10°C.
Aiming to enhance usability, we changed the formulation for this product and were eventually successful in developing a formulation with improved stability.
Furthermore, the product quality design for HANP Injection 1000 was reconstructed based on the QbD framework, enabling us to establish manufacturing conditions that optimized freeze-drying requirements through skillful innovation. We were thereby able to create an enhanced form of HANP Injection 1000, which is a new formulation that features the same quality as before while allowing for storage at room temperature, making it significantly more convenient to use.
After the Great East Japan Earthquake devastated many facilities and created electricity supply constraints, Japan was faced with a situation in which pharmaceuticals could not easily be stored at refrigerated temperatures. As such, the medical community was quite pleased to hear that HANP Injection 1000, a drug necessary for treating the serious condition of heart failure, could now be stored at room temperature