Drug Class Description
Antipsychotic
Generic Name
Olanzapine
Drug Description
Each vial contains 10mg olanzapine. After reconstitution each ml of the solution contains 5 mg olanzapine.
Presentation
Powder for solution for injection.Yellow lyophilised powder.
Indications
Adults:ZYPREXA powder for solution for injection is indicated for the rapid control of agitation and disturbed behaviours in patients with schizophrenia or manic episode, when oral therapy is not appropriate. Treatment with ZYPREXA powder for solution for injection should be discontinued and the use of oral olanzapine should be initiated, as soon as clinically appropriate.
Adult Dosage
For intramuscular use. Do not administer intravenously or subcutaneously. ZYPREXA powder for solution for injection is intended for short-term use only, for up to a maximum of three consecutive days.
The maximum daily dose of olanzapine (including all formulations of olanzapine) is 20mg.
The recommended initial dose for olanzapine injection is 10mg, administered as a single intramuscular injection. A lower dose (5mg or 7.5mg) may be given, on the basis of individual clinical status, which should also include consideration of medicinal products already administered either for maintenance or acute treatment. A second injection, 5-10mg, may be administered 2 hours after the first injection, on the basis of individual clinical status.
Not more than three injections should be given in any 24-hour period and the maximum daily dose of olanzapine of 20mg (including all formulations) should not be exceeded.
Renal and/or hepatic impairment
