部份中文左旋半胱氨酸处方资料（仅供参考）
英文名：L-Carbocisteine
商品名：Mucodyne
中文名：左旋半胱氨酸片
生产商：杏林制药
药品简介
Mucodyne（L-Carbocisteine）是一种被称为粘液溶解剂的药物。通过分解肺部产生的粘液起作用，有助于使粘液不那么粘稠，因此更容易咳出,也可用于帮助减少呼吸道疾病（如支气管炎、慢性阻塞性肺病或囊性纤维化）中的粘液粘性。肺部产生的粘液也称为痰或痰。
ムコダイン錠250mg／ムコダイン錠500mg
药用分类名称
气道粘液调节和粘膜正常化剂
批准日期：2001年7月
欧文商標名
MUCODYNE Tablets 250mg
MUCODYNE Tablets 500mg
一般名：L-カルボシステイン (L-Carbocisteine) [JAN]
化学名：(2R)-2-Amino-3-carboxymethylsulfanylpropanoic acid
分子式：C5H9NO4S
分子量：179.19
融点：約186℃（分解）
性状：
本产品为白色结晶粉末，没有气味，略带酸度。本产品很难溶于水，几乎不溶于乙醇（95）。本产品溶解在稀盐酸或氢氧化钠试液中。
分配系数：1-辛醇/水系统中为0.0。（pH 2.3至8.0，20°C）
化学構造式：
药效药理
1. 对气道的影响
（1）粘液成分调节作用
慢性气道病患者膀胱中的硅酸，使Fudo的构成比正常化。通过亚硫酸盐气体暴露改变硅酸/富斯科特降解酶和硅酸/富斯科特合成酶活性正常化。同时，抑制粘蛋白（Muc-5ac蛋白）生成增加，这是分泌粘液的主要成分（大鼠）。
（2）杯细胞增生抑制作用
在慢性气道病患者的组织学检查中抑制气道粘膜的杯细胞增生。在亚硫酸盐气体暴露模型中抑制气道杯细胞增生（大鼠）。
（3）气道炎症抑制作用
炎症细胞渗透到气道（数量）因亚硫酸气体暴露而增加的气道，抑制活性氧量和弹性酶活性（大鼠）。抑制由fMLP刺激的人类中性粒细胞的激活。
（4）粘膜正常化作用
促进慢性支气管炎患者支气管粘膜上皮线毛细胞的修复。
2. 对鼻窦的影响
（1）粘液线头发运输能力改善作用
在慢性鼻窦炎患者中，提高鼻粘膜粘液线毛传输能力降低。
（2）粘膜正常化作用
减少鼻窦粘膜的紊乱，由于内毒素注射或亚硫酸盐气体暴露，促进修复（兔子）。
适应症
• 以下疾病的死亡
上呼吸道炎（咽炎、喉炎）、急性支气管炎、支气管哮喘、慢性支气管炎、支气管扩张、肺结核
• 慢性鼻窦炎的排泄
用法与用量
作为碳水化合物半胱氨酸，成人通常每天口服500mg一次三次。此外，年龄，根据症状适当增加或减少。
按剂型的不同剂量如下：
用法和剂量表
包装
片
片剂
250mg：PTP 包装：100片（10片x10），500片（10片x50），1000片（10片x100），2100片（21片x100），3000片（10片x300）瓶装包装：500片
500mg：PTP包装： 100片（10片x10），630片（21片x30），1000片（10片x100），2100片（21片x100）瓶装包装：500片
制造供应商
杏林制药有限公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：
https://www.info.pmda.go.jp/go/pack/2233002F1174_1_02/
MUCODYNE Tablets 250mg（L-carbocisteine）
Brand name :MUCODYNE Tablets 250mg
　Active ingredient:L-carbocisteine
　Dosage form:white tablet (φ8.6mm, 4.5mm thick)
　Print on wrapping:face：ムコダイン　錠250mg, KP-256
reverse side：MUCODYNE Tab. 250mg, ムコダイン 250mg
Effects of this medicine
This medicine is an airway mucus adjuster, and agent to keep the normal mucosa that helps excrete phlegm/nasal mucus to relieve stuffed nose.
It is usually used to treat inflammation of upper respiratory tract, acute bronchitis, bronchial asthma, chronic bronchitis, bronchiectasis, pulmonary tuberculosis (expectoration purpose), chronic sinusitis (drainage purpose).
Before using this medicine, be sure to tell your doctor and pharmacist
If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is ((to be written by a healthcare professional))
General dosage regimen: For adults, take 2 tablets (500mg of the active ingredient) 3 times a day.Dosage may be adjusted according to your disease/age/symptoms. Strictly follow the instructions of your doctor/pharmacist.
If you missed a dose, take a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose.
If you took too much of this medicine (more than ordered), check with your doctor/pharmacist.
Do not stop taking this medicine without the instructions of your doctor.
Precautions while taking this medicine
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: loss of appetite, diarrhea, stomachache, rash, eczema, erythema, swelling, fever, respiratory distress.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
red-eye, rash/redness/fluid-filled blisters appear on skin/mouth area, fever, sore throat [mucocutaneous ocular syndrome, toxic epidermal necrosis]
fatigue, loss of appetite, yellowing of the skin/eyes[liver dysfunction, jaundice]
respiratory distress, edema, urticaria[shock, anaphylaxis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out the reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them.
Internal
Revised: 8/2008
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.