| 简介：
部份中文Neolamin 3B处方资料（仅供参考）
英文名：Thiamine Disulfide/Pyridoxine Hydrochloride/Hydroxocobalamin Acetate
商标名：Neolamin 3B Intravenous
中文名：硫胺素二硫化物/盐酸吡哆醇/醋酸羟钴胺素静注用
生产商：日本化薬
药物分类名称
神经肌肉功能激活剂
欧文商標名
Neolamin 3B Intravenous
1.一般名：チアミンジスルフィド(略号 TDS)
(Thiamine Disulfide)
化学名：N ,N '-{Dithiobis〔2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl〕}bis{N -〔(4-amino-2-methyl-5-pyrimidinyl)methyl〕formamide}
分子式：C24H34N8O4S2
分子量：562.71
構造式：
性状：
硫胺素二硫化物为白色至浅黄白色粉末，无气味或略带异味，味微苦。
难溶于乙醇（95），几乎不溶于水或乙醚。 它可溶于稀盐酸或稀硝酸。 饱和水溶液几乎是中性的。
2. 一般名：ピリドキシン塩酸塩
(Pyridoxine Hydrochloride)
化学名：4,5-Bis(hydroxymethyl)-2-methylpyridine-3-ol monohydrochloride
分子式：C8H11NO3・HCl
分子量：205.64
構造式：
性状：
盐酸吡哆醇是白色至微黄色结晶粉末。
它易溶于水，难溶于乙醇（99.5），几乎不溶于乙酸酐，乙酸（100）。
它随着光逐渐变化。
3. 一般名：ヒドロキソコバラミン酢酸塩
(Hydroxocobalamin Acetate)
化学名：Coα-[α-(5,6-Dimethylbenz-1H -imidazol-1-yl)]-Coβ-hydroxocobamide monoacetate
分子式：C62H89CoN13O15P・C2H4O2
分子量：1406.41
構造式：
性状：
Hydroxocobalamin acetate是一种深红色晶体或粉末，没有气味。
它易溶于水，几乎不溶于乙醇（95），几乎不溶于乙醚。
它具有吸湿性。
药用药理学
1.新生素·套管溶液对神经再生的影响
使用大鼠的电生理学方法检查新生素·套管溶液对坐骨神经挤压引起的神经损伤愈合过程的影响，结果，新生素·套管溶液被加压 虽然它不会影响退行性神经的退行性进展，但它被认为可以促进神经支配的恢复。
2. Neoramine·Sleeve Solution对丙烯酰胺中毒性神经炎的影响2）Neoramine·Sleeve Solution和使用大鼠的各活性成分的效果
（1）观察一般症状的变化，
（2）神经传导速度测量。
（1）二硫化硫胺，盐酸吡哆醇，羟钴胺和Neoramin-Suribi溶液抑制丙烯酰胺中毒大鼠的死亡，其效果被认为是最强的Neoramin-Suribi溶液。为的异常症状的表达每种维生素和Neoramin-Suribi溶液丙烯酰胺中毒显示针对丙烯酰胺停药后恢复症状没有明显的抑制作用，促进在所有四个组中观察到的恢复，尤其是在Neolamine·Sleeve液体组中非常出色。
为了在神经传导速度由于丙烯酰胺相对增加的抑制效果
（2）大鼠的增长，Neoramin-Suribi溶液显著抑制（4周），也促进停药丙烯酰胺给药后的恢复。
3.神经病理学检索
维生素B群对大鼠丙烯酰胺神经炎的抑制作用的组织学图像的定量研究表明，有髓鞘纤维的变形程度和髓鞘面积与髓鞘纤维面积的比例在neolamin / 有髓纤维横截面积，单位面积，单位面积退行性有髓纤维数，Seavan细胞核数，电子显微镜观察及腰椎前角细胞RNA含量的分布 观察到抑制趋势。
适应症
○当药物中含有的维生素需求增加且进食不足时，供应（消耗性疾病，孕妇，哺乳期妇女等）
○推测在以下疾病中，涉及该药物中含有的维生素的缺乏或代谢紊乱
●神经痛
●肌肉疼痛·关节痛
●周围神经炎·周围神经麻痹
即使没有效果，也不应随便在月球上使用。
用法与用量
每天缓慢静脉注射10mL普通成人。另外，应根据您的年龄和症状增加或减少。
包装
10安瓿，50安瓿
生产商：日本化薬
完整处方资料附件：http://www.info.pmda.go.jp/go/pack/3179504A1116_1_12/
Neolamin 3B Intravenous（Thiamine Disulfide/Pyridoxine Hydrochloride/Hydroxocobalamin Acetate）
Name of drug classification
Neuromuscular function activator
Sales name
Neoramine · Sleeve Solution (for intravenous injection)
composition
Neoramine · Sleeve Solution (for intravenous injection) contains the following ingredients in 10 mL of 1 tube.
Active ingredient · content
Thiamine disulfide 50 mg
Pyridoxine hydrochloride 100 mg
As hydroxocobalamin acetate acetate hydroxocobalamin 1, 000 μg
Additive/content
Urea 50 mg
pH regulator
Contraindication
Patients with a history of hypersensitivity to this drug and thiamine disulfide
Indication or effect
○ Supply (consumable diseases, pregnant women, nursing women, etc.) when demand for vitamins contained in this drug increases and ingestion from meals is insufficient
○ It is presumed that, among the following diseases, deficiency or metabolic disorder of vitamins contained in this drug is involved
● Neuralgia
● Muscle pain · arthralgia
● peripheral neuritis · peripheral nerve paralysis
Should not be used casually over the moon even though there is no effect.
Slowly intravenously inject 10 mL of usual adult once a day.
Incidentally, it should be increased or decreased according to your age and symptoms
Serious side effects
Shock (<0.1%), anaphylactoid symptoms
Shock, anaphylactoid-like symptoms may occur, so if you have general skin skin flushing, itching, blood pressure decrease, chest tightness, dyspnoea, convulsions etc. appear immediately, discontinue administration and take appropriate measures about.
Medicinal pharmacology
Effect of neolamine · Sleeve's solution on nerve regeneration
As a result of investigating the effect of neolamine · Sleeve's solution on the healing process of neuropathy due to sciatic nerve crush by electrophysiological method using rat, neoramine · Sleeve's solution does not affect degenerative progression of crush nerve, It is considered to promote the recovery of innervation.
Effect of neolamine · Sleeve's solution on acrylamide toxic neuritis
Using rats, the effect of neolamine · Sleeve's solution and its respective active ingredients
(1) observation of changes in general symptoms,
(2) nerve conduction velocity measurements.
Thiamine disulfide, pyridoxine hydrochloride, hydroxocobalamin and neolamine · Sleeve solution inhibit the death of acrylamide intoxicated rats, but Neoramine · Sleeve's solution is considered to be the most effective. For the expression of abnormal symptoms of acrylamide poisoning, each vitamin and neolamine · sleevy liquid did not show obvious inhibitory effect, but recovery of symptoms after the discontinuation of acrylamide was found to promote recovery in all 4 groups, It was remarkable in Neolamine · Sleeve liquid group.
Neoramine/Sleeve's solution significantly inhibited (4 th week) against the inhibitory action of acrylamide against the increase in nerve conduction velocity associated with the growth of rat and promoted recovery after discontinuation of acrylamide administration.
Neuropathological search
Quantitative studies of histological images of the inhibitory effect of vitamin B group on rat acrylamide neuritis revealed that the degree of deformity of myelinated fibers and the ratio of myelin sheath area and myelinated fiber area in neolamin / The distribution of cross-sectional area of myelinated fibers, the interstitial area, the number of degenerative myelinated fibers in the unit area, the number of nuclei of Seavan cells, the electron microscopic observation and the RNA amount in the lumbar cord anterior horn cells A tendency of suppression was observed.
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