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Thiamine Disulfide/Pyridoxine Hydrochloride/Hydroxocobalamin Acetate
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Neolamin 3B Intravenous£¨Thiamine Disulfide/Pyridoxine Hydrochloride/Hydroxocobalamin Acetate£©
Name of drug classification
Neuromuscular function activator
Sales name
Neoramine · Sleeve Solution (for intravenous injection)
composition
Neoramine · Sleeve Solution (for intravenous injection) contains the following ingredients in 10 mL of 1 tube.
Active ingredient · content
Thiamine disulfide 50 mg
Pyridoxine hydrochloride 100 mg
As hydroxocobalamin acetate acetate hydroxocobalamin 1, 000 μg
Additive/content
Urea 50 mg
pH regulator
Contraindication
Patients with a history of hypersensitivity to this drug and thiamine disulfide
Indication or effect
¡ð Supply (consumable diseases, pregnant women, nursing women, etc.) when demand for vitamins contained in this drug increases and ingestion from meals is insufficient
¡ð It is presumed that, among the following diseases, deficiency or metabolic disorder of vitamins contained in this drug is involved
¡ñ Neuralgia
¡ñ Muscle pain · arthralgia
¡ñ peripheral neuritis · peripheral nerve paralysis
Should not be used casually over the moon even though there is no effect.
Slowly intravenously inject 10 mL of usual adult once a day.
Incidentally, it should be increased or decreased according to your age and symptoms
Serious side effects
Shock (<0.1%), anaphylactoid symptoms
Shock, anaphylactoid-like symptoms may occur, so if you have general skin skin flushing, itching, blood pressure decrease, chest tightness, dyspnoea, convulsions etc. appear immediately, discontinue administration and take appropriate measures about.
Medicinal pharmacology
Effect of neolamine · Sleeve's solution on nerve regeneration
As a result of investigating the effect of neolamine · Sleeve's solution on the healing process of neuropathy due to sciatic nerve crush by electrophysiological method using rat, neoramine · Sleeve's solution does not affect degenerative progression of crush nerve, It is considered to promote the recovery of innervation.
Effect of neolamine · Sleeve's solution on acrylamide toxic neuritis
Using rats, the effect of neolamine · Sleeve's solution and its respective active ingredients
(1) observation of changes in general symptoms,
(2) nerve conduction velocity measurements.
Thiamine disulfide, pyridoxine hydrochloride, hydroxocobalamin and neolamine · Sleeve solution inhibit the death of acrylamide intoxicated rats, but Neoramine · Sleeve's solution is considered to be the most effective. For the expression of abnormal symptoms of acrylamide poisoning, each vitamin and neolamine · sleevy liquid did not show obvious inhibitory effect, but recovery of symptoms after the discontinuation of acrylamide was found to promote recovery in all 4 groups, It was remarkable in Neolamine · Sleeve liquid group.
Neoramine/Sleeve's solution significantly inhibited (4 th week) against the inhibitory action of acrylamide against the increase in nerve conduction velocity associated with the growth of rat and promoted recovery after discontinuation of acrylamide administration.
Neuropathological search
Quantitative studies of histological images of the inhibitory effect of vitamin B group on rat acrylamide neuritis revealed that the degree of deformity of myelinated fibers and the ratio of myelin sheath area and myelinated fiber area in neolamin / The distribution of cross-sectional area of myelinated fibers, the interstitial area, the number of degenerative myelinated fibers in the unit area, the number of nuclei of Seavan cells, the electron microscopic observation and the RNA amount in the lumbar cord anterior horn cells A tendency of suppression was observed.

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