部份中文盐酸度洛西汀处方资料（仅供参考）
中文药名：盐酸度洛西汀
英文药名：Cymbal（Duloxetine Hydrochloride）
生产厂家：日本塩野義製薬
药物分类名称
5-羟色胺·去甲肾上腺素再摄取抑制剂
批准日期：2010年4月
欧文商標名
Cymbal
一般的名称：デュロキセチン塩酸塩（JAN）
Duloxetine Hydrochloride
化学名：(+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine monohydrochloride
分子式：C18H19NOS・HCl
分子量：333.88
化学構造式：
性状：
这是一个白色粉末或块。
易溶于甲醇或二甲基亚砜，微溶于乙醇（99.5），微溶于水。
熔点：165℃
审批条件
制定药品风险管理计划并适当执行。
药效药理
1. 薬理作用
（1）减少大鼠强迫游泳试验中的不动行为。
（2）大鼠的学习能力得到提高。
（3）大鼠神经性疼痛模型（坐骨神经部分结扎模型和L5 / L6脊神经结扎模型）等疼痛模型（大鼠福尔马林疼痛模型，小鼠醋酸扭体试验，大鼠角叉菜胶试验和大鼠辣椒素诱导的机械性异常性疼痛这表明在模型镇痛作用）。
2. 作用机序
（1）抑制大鼠下丘脑或大脑下丘脑5-羟色胺和去甲肾上腺素的摄取。 （体外，离体和体内）
（2）增加大鼠额叶皮层中细胞外5-羟色胺和去甲肾上腺素的浓度。 （体内）
（3）对各种神经递质受体的结合抑制活性和单胺氧化酶抑制活性比血清素和去甲肾上腺素摄取抑制活性弱。 （体外）
适应病症
○抑郁·抑郁症
○与下列疾病有关的疼痛
糖尿病神经病变
纤维肌痛
慢性腰背痛
骨性关节炎
用法与用量
1.抑郁/抑郁状态，与糖尿病性神经病相关的疼痛
成人，每天早餐一次，40mg作为度洛西汀口服给药。 每天20mg开始给药，每隔一周或更长时间，以每日剂量增加20mg。另外，当效果不足时，可以增加到60毫克/天。
2.与纤维肌痛相关的疼痛，与慢性腰背痛相关的疼痛，与骨关节炎相关的疼痛。
每天早餐后，将60mg度洛西汀口服给予成年人一次。 每天20mg开始给药，每隔一周或更长时间，以每日剂量增加20mg。
包装
胶囊
20毫克：瓶500粒 PTP 100粒（10粒×10），PTP 500胶囊（10粒×50）
30毫克：瓶500粒 PTP 100粒（10粒×10）
制造商
Shionogi＆Co.Ltd.
提示，以上中文资料不够完整，使用者以原处方资料为准。。
完整说明书附件：http://www.info.pmda.go.jp/go/pack/1179052M1022_2_18/
Antidepressant drug "Sign Baltac capsule 20 mg, 30 mg
Shionogi Pharmaceutical Co., Ltd. and Eli Lilly Japan, antidepressant "Sign Baltaca capsule 20 mg, 30 mg" is released: April 19, 2010
Announcement of new release of antidepressant "Signature Balta (R) capsule 20 mg, 30 mg"
Shionogi Pharmaceutical Co., Ltd. (Head office: Osaka-shi, Chuo-ku, President: Isao Teshiki, hereinafter "Shionogi Pharmaceutical") and Eli Lilly Co., Ltd. (Headquarters: Chuo-ku, Kobe, President and CEO: Alfonso G Zuruetta, hereinafter referred to as "Japan Eli Lilly") has been used to treat serotonin · noradrenaline reuptake inhibitor "CIGALTAR® (R) capsule 20 mg" "CIGALTAR® capsule 30 mg" (generic name: duloxetine hydrochloride) We are pleased to inform you that it will be released on April 19 as a remedy for the condition.
Signorbalta (R) is a serotonin / noradrenaline reuptake inhibitor (SNRI) created at Eli Lilly and Company in the United States and has since been released in the United States since August 2004 in the United States It was approved in 99 countries and prescribed to about 18 million people. In Japan, Shionogi received manufacturing and marketing approval in January, and in the future we will promote joint sales activities by both Eli Lilly Japan and Shionogi Pharmaceutical. Since this drug can be expected to have effects on various depressive symptoms including good symptoms as well as psychiatric symptoms and good remission rates with oral administration once a day, it is possible to recover from depression and return to society I think that it is a medicine that can help you.
Shionogi Pharmaceutical Co., Ltd. and Eli Lilly Japan will provide high-quality information on treatment of depression / depression through promotion of co-marketing activities of Cymbalta (R), and will contribute to patient's treatment and quality of life improvement, I will do my best.
Product overview of "Sign Balt (R)"
Product name: Sign Balta (R) capsule 20 mg, 30 mg (Cymbalta (R))
Common name: Duloxetine hydrochloride
Indications / effects: depression · depression
Dosage / Dosage: Usually, adults take 40 mg orally as duloxetine after breakfast once a day. Administration starts at 20 mg daily and increases by 20 mg as a daily dose at intervals of 1 week or more.
Incidentally, when the effect is insufficient, it can be increased to 60 mg / day.
Manufacture and sale approval date: January 20, 2010
Drug price criterion Listing date: April 16, 2010
Release date: April 19, 2010