2011年1月21日美国食品药品监督管理局(FDA)批准Viibryd片(盐酸维拉佐酮)治疗成年中重度抑郁症。
重度抑郁症，也称为重性抑郁，特征是症状干扰人们工作，睡眠，学习，饮食和享受一次愉快活动的能力。在人一生中重性抑郁的发作往往反复发作，尽管有些人金发生一次。
重性抑郁的体征和症状包括：抑郁情绪，对寻常活动丧失兴趣，体重或食欲显著变化，失眠或过度睡眠(嗜睡)，坐立不安/调步(精神运动性激越)，疲乏增加，有罪感或自卑感，思维缓慢或注意力不集中,和自杀意。
FDA药物评价和研究中心精神产品部主任Thomas Laughren医学博士说“重度抑郁症使人们不能和阻碍正常功能”“影响每个人的药很难，所以重要是抑郁病患者可得到各种各样治疗选择”。
在临床试验中用Viibryd患者被报道最频繁不良反应包括腹泻，恶心，呕吐，和失眠。
将可得到10，20和40mg片药物。
Viibryd和所有其它抗抑郁药物都有黑框警告和患者用药指南描述在儿童，青春期，和18至24岁年轻成年中初始治疗期间自杀想法和行为风险增加。
警告还说资料没有显示成年中年龄大于24风险增加而年龄65岁和以上患者服用抗抑郁药自杀想法和行为风险减低。警告说抑郁和其它延长精神疾患本身是引起自杀最重要原因而从开始用这些药物需要严密监视患者。
VIIBRYD（维拉佐酮盐酸盐）的片剂，用于口服用途
美国首次批准：2011
警告：自杀的想法和行为，请参阅完整处方信息了解完整的黑框警告。
抗抑郁药增加自杀想法和行为的风险24岁及以下岁的患者。
监测临床恶化和自杀念头和行为的出现。
VIIBRYD的安全性和有效性还没有建立在儿科患者。
目前的主要变化
剂量和给药方法  03/2015
警告和注意事项  04/2014
警告和注意事项  07/2014
作用机制
维拉佐酮抗抑郁作用的机制未完全了解但被认为与它在CNS中通过选择性抑制5羟色胺再摄取的5羟色胺能活性增加有关。维拉佐酮也是5羟色胺能5-HT1A受体的部分激动剂，然而，不知道对5羟色胺传递的净结果和它在维拉佐酮抗抑郁中的作用。
适应症和用法
VIIBRYD的适应症为抑郁障碍（MDD）的治疗。
用法用量
推荐的目标剂量：20毫克至40毫克，每天的食物一次。
滴定：开始用10毫克的初始剂量，每天一次持续7天，然后是20毫克，每天一次。剂量可增至40毫克，每天一次最低剂量增加之间7天后
在此之前开始VIIBRYD，屏幕双相情感障碍
当停止VIIBRYD，逐步减少剂量
剂型和规格
片剂：10毫克，20毫克和40毫克
禁忌
同时使用单胺氧化酶抑制剂（单胺氧化抑制剂），或在停药后14天内使用单胺氧化抑制剂
警告和注意事项
羟色胺综合征：单独使用时的风险增加时，共同给予与其他血清素药物（如SSRI，SNRI，曲坦类），而且还。如果发生了，停止VIIBRYD并开始支持治疗
出血的风险增加：伴随使用阿司匹林，非类固醇抗炎药（NSAIDs），其它抗血小板药物，华法林，以及其它抗凝血剂可能增加这种风险
激活工坊/轻躁狂：屏幕患者为双相情感障碍。
癫痫发作：可与治疗发生。请谨慎使用患者的癫痫症。
闭角型青光眼：避免使用抗抑郁药，包括VIIBRYD的，患者未经治疗的解剖狭窄的角度。
不良反应
最常见的不良反应（发生率≥5％和安慰剂的至少两倍的速率）：腹泻，恶心，呕吐，和失眠。
药物相互作用
CYP3A4抑制剂：本VIIBRYD剂量不应超过20毫克，每天一次合作时，给予强CYP3A4抑制剂。
CYP3A4诱导：考虑在1至2周增加VIIBRYD剂量由2倍，至多80毫克每日一次同时使用具有强CYP3A4诱导剂为大于14天时。
特殊人群中使用
妊娠：妊娠晚期的使用可能会增加风险的持续性肺动脉高压和戒断新生儿。
What is the most important information I should know about VIIBRYD?
VIIBRYD and other antidepressant medicines may cause serious side effects. Call your healthcare provider right away if you have any of the symptoms described below, or call 911 if there is an emergency.
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS
Antidepressants increased the risk of suicidal thoughts or actions in some people 24 years of age and younger. Watch closely for worsening depression and for suicidal thoughts and behaviors. Call your healthcare provider right away if you notice any new or sudden changes in mood, behavior, thoughts or feelings. Pay particular attention when VIIBRYD is started or when the dose is changed.
VIIBRYD is not approved for use in patients under 18.
Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
•Attempts to commit suicide; acting on dangerous impulses; acting aggressive or violent; thoughts about suicide or dying; new or worse depression, anxiety, or panic attacks; feeling agitated, restless, angry or irritable; trouble sleeping; an increase in activity or talking more than normal (mania); or other unusual changes in behavior or mood
Serotonin Syndrome: Agitation, hallucinations, coma or other changes in mental status; coordination problems or muscle twitching; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea; muscle stiffness or tightness.
Increased chance of bleeding: VIIBRYD and other antidepressant medicines may increase your chance of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.
Manic episodes: Greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.
Discontinuation symptoms: Do not suddenly stop VIIBRYD without first talking to your healthcare provider. Stopping VIIBRYD suddenly may cause serious symptoms including: flu-like symptoms (eg, headache, sweating, nausea); anxiety, high or low mood, irritability, feeling restless or sleepy; dizziness, electric shock-like sensations, tremor, and confusion.

Seizures or convulsions.
Glaucoma (angle-closure glaucoma): Many antidepressants, including VIIBRYD, may cause an eye problem called angle-closure glaucoma. Call your healthcare provider if you have changes in your vision or eye pain.
Low salt (sodium) levels in the blood: Elderly people may be at greater risk for this. Symptoms may include headache; weakness or feeling unsteady; confusion, problems concentrating or thinking or memory problems.
Who should not take VIIBRYD?
•Do not take any drugs known as monoamine oxidase inhibitors (MAOIs), including linezolid (an antibiotic), with VIIBRYD or within 14 days of stopping VIIBRYD
•Do not start VIIBRYD if you started or stopped taking an MAOI in the last 14 days
People who take VIIBRYD close in time to taking an MAOI may have serious or even life-threatening side effects.
What should I tell my healthcare provider before taking VIIBRYD?
•Tell your healthcare provider about any medical conditions or if you:
■Have liver or kidney problems
■Have or had mania, bipolar disorder (manic depression), seizures or convulsions
■Have or had bleeding problems. VIIBRYD may increase your chance of bleeding or bruising
■Have low salt (sodium) levels in your blood or are taking diuretics (water pills)
■Drink alcohol
■Are pregnant, breastfeeding or are planning to become pregnant or to breastfeed
•Tell your healthcare provider about all prescription, over-the-counter medications, vitamins, and herbal supplements you are taking or plan to take, especially:
■Triptans used to treat migraine headaches; medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, buspirone, or antipsychotics; tramadol, mephenytoin (Mesantoin) or over-the-counter supplements such as tryptophan or St. John’s Wort; this is necessary to avoid a potentially life-threatening condition
■Aspirin, NSAID pain relievers, or blood thinners (eg, warfarin, Coumadin, or Jantoven) because they may increase the risk of bleeding
■Diuretics (water pills)
What should I avoid when taking VIIBRYD?
•Until you know how VIIBRYD affects you, you should not drive, operate heavy machinery, or engage in other dangerous activities. Avoid drinking alcohol while taking VIIBRYD.
What are the most common side effects of VIIBRYD?
•The most common side effects in people taking VIIBRYD include diarrhea, nausea or vomiting, and trouble sleeping.
•Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of VIIBRYD. For more information, ask your healthcare provider or pharmacist.