部份中文草酸依地普仑处方资料（仅供参考）
【通用名】 草酸依地普仑片
【英文名】 Escitalopram Oxalate Tablets
【适应症】治疗抑郁障碍，治疗伴有或不伴有广场恐怖症的惊恐障碍。
【用法用量】重症抑郁症：起始剂量一日一次10mg，一周后可以增至一日一次20mg,早晨或晚上口服。一般情况下应持续几个月甚至更长时间的治疗；老年患者或肝功能不全者建议一日一次10mg，轻度或中度肾功能不全者无需调节剂量；严重肾功能不全者慎用。
【不良反应】约5％的患者有失眠、阳萎、恶心、便秘、多汗、口干、疲劳、嗜睡；约2％的患者有头痛、上呼吸道感染、背痛、咽炎和焦虑等；偶见报道可引起躁狂或轻度躁狂或低钠血。有惊厥史的患者应慎用。

ESCITALOPRAM
DESCRIPTION :Escitalopram is a super selective serotonin (5-HT) reuptake inhibitor with potent antidepressant and anxiolytic activity. Its extreme selectivity appears to be unique amongst the selective serotonin reuptake inhibitors (SSRIs)
INDICATIONS
Escitalopram is indicated for:
Treatment of major depressive disorder, generalized anxiety disorder, panic disorder with or without agoraphobia, social anxiety disorders.
DOSAGE AND ADMINISTRATION
Escitalopram is administered as a single daily dose and may be taken withor without food.
Major depressive disorder:
Usual dosage is 10 mg once daily. Depending on individual patientresponse, the dose may be increased to a maximum of 20 mg daily.
Usually 2-4 weeks are necessary to obtain antidepressant response.
After the symptoms resolve, treatment for at least 6 months is requiredfor consolidation of the response.
Generalized anxiety disorder:
Initial dosage is 10 mg once daily. Depending on the individualpatient’s response, the dose may be increased to a maximum of 20mg daily.
Long-term treatment for the responders can be continued forat least 6 months on 20 mg daily.
Panic disorder with or without agoraphobia:
An initial dose of 5 mg is recommended for the first week beforeincreasing the dose to 10 mg daily. The dose may be furtherincreased, up to a maximum of 20 mg daily, dependent on individualpatient response.
Maximum effectiveness is reached after about 3 months. Thetreatment lasts severalmonths.
Social anxiety disorder:
Usual dosage is 10 mg once daily. Usually 2-4 weeks are necessary toobtain symptom relief. The dose may subsequently, depending onindividual patient response, be decreased to 5 mg or increased to amaximum of 20 mg daily.
Use in children and adolescents under 18 years of age:
Not recommended.
CONTRAINDICATION
Hypersensitivity to escitalopram or to any of the excipients.
SIDE-EFFECTS
Side-effects are most frequent during the first or second week of treatment and usually decrease in intensity and frequency with continued treatment. Most common side effects are- decreased appetite, decreased libido, insomnia, somnolence, dizziness, sinusitis, nausea, diarrhoea, constipation, sweating increased, ejaculation disorder, impotence, fatigue, pyrexia
OVERDOSE
Symptoms of overdose includes tremor, somnolence, unconsciousness, seizures,tachycardia, changes in the EGG, respiratory depression etc. There is no specific antidote.
Establish and maintain an airway, ensure adequate oxygenation and respiratory function. Gastric lavage should be carried out as soon as possible after oral ingestion.
The use of activated charcoal should be considered. Cardiac and vital signs monitoring are recommended along with general symptomatic supportive measures.
DRUG INTERACTIONS
CNS drugs – Caution should be used when escitalopram is taken incombination with other centrally acting drugs.
MAO Inhibitors–There have been reportsofserious,sometimesfatalreactionswhenescitalopram is taken in combination with MAOinhibitors.
PRECAUTIONS
There have been spontaneous reports of adverse events occurring upon discontinuation of this drug (dysphoric mood, irritability, agitation, anxiety, confusion, sensory disturbances, insomnia, dizziness etc), particularly when abrupt. A gradual reduction in the dose rather than abrupt cessation is recommended to avoid possible withdrawal reactions.
USE IN PREGNANCY AND LACTATION Use in pregnancy:
There are limited clinical data available regarding its use in pregnancy. The risk for humans is unknown. Therefore, escitalopram should not be used during pregnancy unless clearly necessary and only after careful consideration of the risk/benefit. Use in lactation:
It is expected that escitalopram will be excreted into human milk. Breast-feeding women should not be treated with escitalopram or breast-feeding should be discontinued.
PHARMACEUTICAL PRECAUTION
Store in a dry place, away from light, keep out of reach of children.
PACKAGING Escitalopram 5 tablet
Losita®10 tablet
: Box containing 4 strips of 10 tablets each. Each film coated tablet contains escitalopram oxalate INN equivalent to escitalopram 5 mg.
: Box containing 2 strips of 10 tablets each. Each film coated tablet contains escitalopram oxalate INN equivalent to escitalopram 10 mg.