部分中文氟西汀处方资料（仅供参考）
通用名：盐酸氟西汀
药理作用
氟西汀是神经元摄取5－羟色胺的选择性抑制剂，它的抗抑郁活性证实是与抑制神经元摄取5－羟色胺的能力有直接关系。
病人如有肝损伤可影响百优解的消除。
严重肾损伤病人可导致百优解或其所有代谢物的进一步蓄积。
药代动力学
口服氟西汀单次剂量后6－8小时血药浓度达峰。饭后服用百优解不影响药物的吸收量。
适应症
百优解适用于抑郁症及其伴发之焦虑的治疗。也可用于治疗神经性贪食症和强迫性障碍。
用法用量
抑郁症：建议起始剂量为晨服20mg。如果经数周治疗后，临床症状没有改善，可考虑增加剂量，逐渐增加剂量，比如改为1天2次，早、午各服20mg。
神经性贪食症：建议治疗剂量为每天60mg。
强迫性障碍：建议治疗剂量为每天20-60mg。
以上任何状况下治疗剂量均不能超过每天80mg。
老年患者：建议治疗剂量为每天20mg。
肝功能损伤患者－用量和频度均应减少。
肾功能损伤患者－用量和频度均应减少。氟西汀为口服用药。片剂可溶于一杯水中或直接吞服。
药物过量
征兆或症状：主要为恶心和呕吐。可能出现其它中枢神经兴奋的征兆如激动或抽搐。自上市以来，由于单独服用氟西汀过量所致的死亡病例极端罕见。
治疗：建议进行对症治疗和支持治疗。服用活性炭与催吐或洗胃一样有效甚至更有效。因氟西汀导致的惊厥发作如不能自行缓解，可用地西泮进行治疗。
在氟西汀与其它抗抑郁药共同服用过量时，应格外小心。
不良反应
与使用氟西汀有关的最常见的不良反应为：焦虑、紧张、失眠、困倦、疲劳、震颤、多汗、厌食、恶心、腹泻、头晕。
不太常见的反应为：头痛、口干、消化不良、呕吐。
其它严重的不良反应偶见报道，例如晕厥、心律失常、非正常肝反应、甲状腺功能减退或亢进、出血时间延长、急性脑部综合征和惊厥。|
禁忌症
禁用于对百优解和/或百优解中任何成分过敏的病人。
警告
某些患有与氟西汀有关的皮疹的病人，曾经发展为严重的认为与脉管炎有关的全身反应。与此有关的非常偶然的致命事件也有报道。如发生皮疹或其它任何明显的未知病因的过敏症状均应立即停药。
注意事项
据报道，部分病人应用氟西汀后可出现躁狂/轻躁狂。
对驾驶的影响：对操作危险机械包括机动车的病人应予以警告，直至他们确认药物对他们不产生有害的影响为止。
孕妇及哺乳期妇女用药
使用氟西汀的安全性还未研究。因此，妊娠期妇女除非必要，否则禁用此药。百优解可从母乳中分泌，因此授乳期妇女慎用百优解。
儿童用药
由于缺乏百优解应用于儿童的经验资料，故不宜用于儿童。
老年患者用药
临床研究未发现与年龄有关的不良现象产生。
药物相互作用
百优解偶尔可增加其它抗抑郁药的血药水平。
据报道，糖尿病人在应用百优解治疗期间有可能出现低血糖症，中断治疗后有可能出现高血糖症。应适当调整胰岛素用量和/或口服降血糖药。
百优解与单胺氧化酶抑制剂（MAOI）不能同时服用，也不能在中断MAOI治疗后14日内使用。中断氟西汀治疗和应用MAOI治疗的间隔期限应严格遵守5周的时间。
【贮藏】室温15-25°C保存，
【有效期】3年。
Fluoxetine (Generic Prozac®) is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, bulimia, obsessive compulsive disorders (OCD) and severe symptoms of premenstrual syndrome (PMDD). Fluoxetine works by helping to restore the balance of certain natural chemicals in the brain.
Fluoxetine (Generic Prozac)
Important Fluoxetine Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Common Brand Name(s)
Prozac, Sarafem
Fluoxetine Uses
Fluoxetine is used to treat depression, bulimia (an eating disorder), obsessive compulsive disorders (OCD), and severe symptoms of premenstrual syndrome (premenstrual dysphoric disorder-PMDD). Fluoxetine works by helping to restore the balance of certain natural chemicals in the brain.
Other Fluoxetine Uses
Fluoxetine has also been used to treat panic attacks, obesity, and alcoholism.
How to Use Fluoxetine
Take Fluoxetine by mouth usually once daily in the morning, with or without food; or as directed by your doctor. The Fluoxetine dosage is based on your medical condition and response to therapy. Some medical conditions may require a different dosing schedule (e.g., twice daily in the morning and at noon) as determined by your doctor. Take Fluoxetine exactly as prescribed. It is important to continue taking Fluoxetine even if you feel well. Also, do not stop taking Fluoxetine without consulting your doctor. It may take up to 4 weeks before the full benefit of this drug takes effect.
Fluoxetine Side Effects
Nausea, headache, trouble sleeping, dry mouth, drowsiness, sweating, or upset stomach may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: loss of appetite, unusual weight loss, unusual or severe mental/mood changes, uncontrolled movements (tremor), decreased interest in sex, flu-like symptoms (e.g., chills, fever, muscle aches, weakness). Tell your doctor immediately if any of these unlikely but serious side effects occur: vision changes, trouble swallowing, swelling or white spots on the mouth and/or tongue, changes in sexual ability, painful and/or prolonged erection. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, irregular/fast heartbeat. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
Fluoxetine Precautions
Tell your doctor your medical history, especially of: liver problems, kidney disease, seizures, heart problems, diabetes, any allergies. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. Liquid preparations of this product may contain sugar and/or small amounts of alcohol. Caution is advised if you have diabetes, alcohol dependence, or liver disease. Ask your doctor or pharmacist about the safe use of this product. Caution is advised when using this product in the elderly because they may be more sensitive to the effects of the drug. Fluoxetine should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.
Fluoxetine Drug Interactions
Certain medications taken with this product could result in serious, even fatal, drug interactions. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks, and avoid taking thioridazine within 5 weeks, before or after treatment with Fluoxetine. Consult your doctor or pharmacist for additional information. This drug is not recommended for use with: weight loss medicine (e.g., sibutramine, phentermine), thioridazine, terfenadine, astemizole. Ask your doctor or pharmacist for more details. Tell your doctor of all prescription and nonprescription medication you may use, especially: other SSRI antidepressants (e.g., citalopram, sertraline), nefazodone, trazodone, venlafaxine, "triptan" migraine drugs (e.g., sumatriptan, zolmitriptan), tramadol, tricyclic antidepressants (e.g., amitriptyline, nortriptyline), flecainide, propafenone, haloperidol, clozapine, lithium, tryptophan, "blood thinners" (e.g., warfarin), anti-seizure drugs (e.g., carbamazepine, phenytoin/hydantoins), herbal/natural products (e.g., St John's wort, ayahuasca). Tell your doctor if you take any drugs that cause drowsiness such as: medicine for sleep, tranquilizers, anti-anxiety drugs (e.g., alprazolam), narcotic pain relievers (e.g., codeine), muscle relaxants, psychiatric medicine (e.g., phenothiazines such as chlorpromazine), certain antihistamines (e.g., diphenhydramine). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of these products. Report other drugs which affect the heart rhythm (QTc prolongation), such as: dofetilide, pimozide, sotalol, quinidine, procainamide, sparfloxacin, "water pills" (diuretics such as furosemide or hydrochlorothiazide). Ask your doctor or pharmacist for more details. Fluoxetine may affect the amount of glucose (sugar) in your blood. If you take any anti-diabetes medication (e.g., glipizide, glyburide, metformin), your dosage of these drugs may need to be adjusted when fluoxetine is started or discontinued. Consult your doctor. Do not start or stop any medicine without doctor or pharmacist approval.
Fluoxetine Overdose
If Fluoxetine overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of Fluoxetine overdose may include: irregular heartbeat, fainting, severe dizziness or lightheadedness.
Fluoxetine Notes
Do not share Fluoxetine with others. Laboratory and/or medical tests may be performed to monitor your progress.
Missed Fluoxetine Dose
If you miss a Fluoxetine dose, use it as soon as you remember. If it is near the time of the next Fluoxetine dose, skip the missed Fluoxetine dose and resume your usual dosing schedule. Do not double the Fluoxetine dose to catch up.
Fluoxetine Storage
Store Fluoxetine at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Keep Fluoxetine away from light and moisture.
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