部份中文苯巴比妥处方资料（仅供参考）
商品名：Phenobal tablets
英文名：Phenobarbital
中文名：苯巴比妥片
生产商：第一三共
药品简介
Phenobal是一种长效巴比妥酸盐。会抑制感觉皮层，减少运动活动，改变小脑功能，产生嗜睡、镇静和催眠。其抗惊厥性能在高剂量下表现出来。Phenobal作用于GABAA受体，增加突触抑制。
フェノバール原末／フェノバール散10%／フェノバール錠30mg／フェノバールエリキシル0.4%
药效分类名称
催眠、镇静、抗痉挛剂
批准日期：1944年1月
商標名
PHENOBAL
PHENOBAL POWDER
PHENOBAL TABLETS
PHENOBAL ELIXIR
一般的名称
フェノバルビタール（Phenobarbital）
化学名
5-Ethyl-5-phenylpyrimidine-2, 4, 6（1H, 3H, 5H）-trione
分子式
C12H12N2O3
分子量
232.24
性状
白色结晶或结晶粉末。
极易溶于N，N-二甲基甲酰胺，易溶于乙醇（95）或丙酮，稍难溶于乙腈，极难溶于水。
溶于氢氧化钠试液。
饱和水溶液的pH为5.0～6.0。
化学構造式
融点
175～179℃
使用注意事项
〈散10%〉
本品可能会因光线而逐渐退色（不影响主药含量），故铝袋包装开封后应避免受潮，遮光保存。
〈赤藓碱0.4%〉
将本制剂用水稀释后保存在冰箱等低温场所时，有时会析出主药，因此原则上优选单独、原液给药。
药效药理
作用机制
通过结合存在于GABAA受体亚单位的巴比妥酸衍生物结合部位，提高抑制性传递物质GABA的受体亲和性，增强Cl-通道开口作用，促进神经功能抑制作用。
适应症
○失眠
○不安紧张状态的镇静
○癫痫的痉挛发作
○强直间代发作（整体痉挛发作、大发作）、焦点发作（包括杰克逊型发作）
○自律神经发作、精神运动发作
用法与用量
失眠
作为苯巴比妥，通常在就寝前口服成人1次30～200mg。另外，根据年龄、症状适当增减。
不安紧张状态的镇静、癫痫的痉挛发作、自律神经发作、精神运动发作
作为苯巴比妥，通常成人1天30～200mg，1～4次分次经口给药。另外，根据年龄、症状适当增减。
包装
〈原末〉
（铝袋：玫瑰）100g
〈散10%〉
（铝袋：玫瑰）100g、500g
〈片30mg〉
（PTP）100片（10片）×10）、1000片（10片）×100）、（瓶：玫瑰）1000片
〈0.4%〉
（瓶：玫瑰）500mL
制造销售
藤永制药株式会社
销售
第一三共株式会社
注：以上中文资料不够完整，使用者以原处方资料为准。
完整说明书附件：
https://www.info.pmda.go.jp/go/pack/1125003B2031_1_33/
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PHENOBAL TABLETS 30mg（フェノバール錠30mg） 
Brand name : PHENOBAL TABLETS 30mg
　Active ingredient: Phenobarbital
　Dosage form: white tablet, diameter: 7.0 mm, thickness: 3.0 mm
　Print on wrapping: Phenobal 30 mg, フェノバール 30 mg, フェノバール30, P3
Effects of this medicine
This medicine promotes receptor affinity of inhibitory transmitter (GABA), increases Cl- channel permeability and promotes to suppress nerve function by binding to the binding sites of barbiturates that are in subunits of GABAA receptors.
It is usually used to treat insomnia, convulsive seizures in epilepsy, autonomic seizures or psychomotor seizures, and to relieve anxiety/tension state.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have acute intermittent porphyria...aftereffects of trauma (head injury) or progressive arteriosclerosis, heart/liver/renal disorder...neurosis, hypothyroidism, or tendency to drug dependence or its medical history.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is ((to be written by a healthcare professional))
•In general, for adults, take 30 to 200 mg of the active ingredient in 1 to 4 divided doses a day. For insomnia, take 30 to 200 mg of the active ingredient at a time before bedtime.
The dosage may be adjusted according to your disease, age/symptoms. Strictly follow the instructions.
•For insomnia, take this medicine just before bedtime. If you need to wake up in the middle of sleep after you once fall asleep to do some work, do not take this medicine.
•If you miss a dose, take the missed dose when you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause drowsiness and decreased attention/concentration/reflex movement. Avoid driving a car or operating dangerous machinery.
•Pay attention that alcohol (drinking) may intensify medicinal effects.
•Avoid taking any food containing St. John's wort with this medicine, since it may diminish medicinal effects.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include drowsiness, dizziness and generalized red rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•fever, bloodshot eyes, generalized skin redness and swelling of the skin with rash or blisters [toxic epidermal necrolysis, mucocutaneous ocular syndrome, erythroderma (exfoliative dermatitis)]
•rash, fever, swelling in lymph nodes [hypersensitivity syndrome]
•unable to stop using this medicine and becoming dependent on it [dependence]
•sore throat, fever, nose or gum bleeding [granulocytopenia, decreased platelets]
•general malaise, nausea, yellow discoloration of the skin and the white of eyes [liver dysfunction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct light and moisture. Store at room temperature (1 to 30 degrees Celsius).
•Discard the remainder. Do not store them. Ask the pharmacist or medical institution on how to discard the remainder.
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment