部份中文盐酸哌罗匹隆处方资料（仅供参考）
英文名：Perospirone Hydrochloride Hydrate
商品名：Lullan Tablets
中文名：盐酸哌罗匹隆片
生产商：大日本住友制药
药品简介
Lullan(Perospirone Hydrochloride Hydrate)是一种新型的非典型抗精神病药物，通过阻断脑多巴胺和羟色胺受体来治疗精神疾病，临床主要用于治疗精神分裂症和其他精神疾病伴有明显的精神症状，如抑郁症，或一些脑器质性精神疾病。
ルーラン錠4mg/ルーラン錠8mg/ルーラン錠16mg
药用分类名称
抗精神病剂
批准日期：2007年12月
商標名
Lullan
一般名
ペロスピロン塩酸塩水和物
Perospirone Hydrochloride Hydrate
化学名
cis-N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarboximide monohydrochloride dihydrate
構造式
分子式
C23H30N4O2S・HCl・2H2O
分子量
499.07
性状
它是白色晶体或结晶粉末。 甲醇或乙醇（95）中易溶于乙酰乙酰，不易溶于水，几乎不溶于二乙醚。
熔点
开始在98°C左右熔化，在120°C左右凝固，从185°C附近再次溶解，在190°C左右变得清晰。
药理作用
通过阻断多巴胺2受体，抑制大鼠的行为变化和大鼠的条件避免反应，如情绪化和常规行为，如由甲基安非他明或凋月酮在大鼠和小鼠中，这些效力约为1/3至1/5的哈洛佩里多。
通过阻断血清素2受体，抑制大鼠三氯苯胺或p-氯安非他明引起的前肢痉挛和体温升高等行为变化，其效力比哈洛佩里多强10倍以上。此外，在大鼠的惊恐条件呼吸行为测试（情绪障碍模型）中，我抑制了心理压力引起的呼吸行为（无运动症状）的表达。
大鼠和小鼠的卡皮普西诱导作用，小鼠的径向（寡头动）诱导作用小于哈洛佩里多的1/10。
作用机制
从研究在大鼠大脑中多巴胺代谢旋转或Fos蛋白表达作为指标的作用机制，建议对线体的作用选择性与金字塔外路症状密切相关，与哈洛佩里多相比较弱。
适应症
精神分裂症
用法与用量
通常，从成人每天3次开始，作为盐酸佩罗斯皮隆，逐渐增加。每天口服12至48mg作为维持量，分为三次。
此外，年龄，适当增加或减少症状。然而，每日量不超过48毫克。
临床结果
临床结果概述，包括双盲比较试验如下。
临床效果
精神分裂症的中度或以上改善率为48.3%（173/358例：12-48mg给药例）。 其中，在拆除型、妄想型和残余型中获得了足够的改进率。 此外，当幻觉和妄想作为前景时，高剂量高达28-48mg/天，低剂量12~24mg/天是有效，当自发性缺乏和情感钝麻作为前景。 此外，通过双盲比较试验，该制剂对精神分裂症的效用得到了认可。
包装
片剂
4毫克：[PTP] 100 片 （10 片 x 10）， 1，000 片 （10 片 × 100）[瓶装] 1，000 片
8毫克：[PTP] 100 片 （10 片 x 10）， 1，000 片 （10 片 × 100）[瓶装] 1，000 片
16毫克：[PTP] 100 片 （10 片 x 10）[瓶装] 500 片
制造供应商
大日本住友製薬株式会社
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：
https://www.info.pmda.go.jp/go/pack/1179043F1032_2_24/
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Lullan Tablets 16mg（Perospirone hydrochloride hydrate）
Brand name:Lullan Tablets 16mg
　Active ingredient:
Perospirone hydrochloride hydrate
　Dosage form:
white to yellowish white tablet (major axis: approx. 13.1mm, minor axis: approx. 5.6mm, thickness: approx. 4.0mm)
　Print on wrapping:
(face) ルーラン 16mg, ルーラン, DS059
(back) Lullan 16mg, ルーラン, 16mg
Effects of this medicine
This medicine adjusts the function of brain neurotransmitters (serotonin, dopamine, etc.) to ease strong anxiety and nervousness, and consequently to stabilize patients' mood.
It is usually used to treat schizophrenia.
Before using this medicine, be sure to tell your doctor and pharmacist
If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are in a coma.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
In general for adults, start with 4mg of perospirone hydrochloride 3 times a day, after each meal, and increase the dose gradually. The maintenance dose is 4 to 16mg at a time, 3 times a day, after each meal. The dose may be adjusted according to your age and symptoms. The maximum dose is 48mg a day. 1 tablet contains 16mg of perospirone hydrochloride. Strictly follow the instructions.
If you missed a dose, take the missed dose as soon as possible. If there is less than 4 hours before the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose.
If you took too much of this medicine (more than prescribed), check with your doctor/pharmacist.
Do not stop taking this medicine without the instructions of your doctor.
Precautions while taking this medicine
This medicine may cause sleepiness, diminished attention, loss of concentration, decreased reflex motor capacity, etc. Therefore do not drive a car or operate dangerous machinery while taking it.
Please note that alcohol may intensify this medicine's effect.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include restless, tremor in the limbs, rigidity muscle, articulatory disorder (slurred speech), sleeplessness, sleepiness, rash, erythema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
sudden onset of fever, rigidity muscle, tremor in the limbs[neuroleptic malignant syndrome]
constant involuntary movement of the face, especially around the mouth [tardive dyskinesia]
loss of appetite, nausea, vomiting, marked constipation[paralytic ileus]
loss of appetite, nausea, vomiting, convulsion [syndrome of inappropriate antidiuretic hormone secretion]
convulsion[convulsion]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them. Ask the pharmacist or the medical institution staff how to discard.
Internal
Revised: 7/2019
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.