部份中文盐酸普拉克索处方资料（仅供参考）
商品名：Mirapex-LA Tablets
英文名：Pramipexole Hydrochloride Hydrate
中文名：盐酸普拉克索片
生产商：勃林格殷格翰
药品简介
Mirapex-LA（Pramipexole Hydrochloride Hydrate，普拉克索）片是一种多巴胺受体激动剂，用于治疗特发性帕金森病的体征和症状，单独(无左旋多巴)或与左旋多巴联用。
ミラペックスLA錠0.375mg／ミラペックスLA錠1.5mg
药效分类名称
多巴胺能帕金森病治疗缓释制剂
批准日期：2011年7月
商標名
Mirapex-LA Tablets 0.375mg
Mirapex-LA Tablets 1.5mg
一般名
プラミペキソール塩酸塩水和物（JAN）
Pramipexole Hydrochloride Hydrate（JAN）
Pramipexole（INN）
化学名
(S)-2-Amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole dihydrochloride monohydrate
化学構造式
分子式
C10H17N3S・2HCl・H2O
分子量
302.26
性状
白色结晶或结晶性粉末。 极易溶于水，微溶于甲醇，微溶于乙醇（95）。
熔点
约290℃（分解）
分配系数
log D = -0.2（l-辛醇/0.067 mol/L磷酸盐缓冲液，pH 7.4，20°C）
药效药理
1. 帕金森病样症状改善效果
(1) MPTP引起的症状改善效果
MPTP（1-甲基-4-苯基-1,2,3,6-四氢吡啶）诱导的帕金森病样症状在比溴隐亭甲磺酸盐（恒河猴）更低的剂量下得到改善。
(2) 对运动不能和僵硬的改善作用
它显示出对利血平引起的运动不能和僵硬的改善作用。发现这些改善效果通过与左旋多巴（小鼠）的组合使用而增强。
2. 作用机制
(1) 对多巴胺D2受体的亲和力（体外）
这种药物对多巴胺D2受体家族（D2、D3、D4）表现出很强的亲和力。
未显示对D1和D5受体的亲和力。
(2)多巴胺D2受体刺激作用
在MPTP诱导的半帕金森病模型动物中，纹状体突触后多巴胺D2受体刺激作用诱导向受伤侧（恒河猴）的相反侧旋转行为。它还显示出对氟哌啶醇诱导的僵住症症状（大鼠）的改善作用。
适应症
帕金森病
用法与用量
一般成人盐酸普拉克索水合物日剂量为0.375mg，饭后口服，每日1次，第2周每日0.75mg，剂量应增加0.75mg，维持应确定剂量（标准日剂量为1.5至4.5毫克，每日一次，饭后口服）。剂量可根据您的年龄和症状进行调整，但每日剂量不应超过4.5毫克。
包装
LA片
0.375毫克：100 片（10 片 x 10）PTP
1.5毫克：100 片（10 片 x 10）PTP
制造和销售
日本勃林格殷格翰株式会社
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明附件：
https://www.info.pmda.go.jp/go/pack/1169012G1028_1_07/
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The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name : Mirapex-LA Tablets 15mg
　Active ingredient: Pramipexole hydrochloride hydrate
　Dosage form: White Tablet (9.0mm in diameter, 4.1mm in thickness, 0.25g in weight)
　Print on wrapping: (Face） Mirapex-LA 5mg, P1, (back) ミラペックスLA 0.375mg,社マーク, Boehringer Ingelheim
Effects of this medicine
By stimulating dopamine D2 receptors in the brain, this medicine improves symptoms of Parkinson's disease (shaking of hands, muscle stiffness, slow movement and inability to maintain posture).
Usually, this medicine is used to treat Parkinson's disease.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.)to any medicines.
If you have problems in kidney requiring dialysis.
•If you are pregnant, possibly pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, start with 1 tablet (0.375mg of pramipexole hydrochloride hydrate) after the meal once daily for the first week, and increase to 2 tablets (0.75mg) daily for the second week. Thereafter increase the daily dose by an increment of 2 tablets (0.75mg) at weekly intervals by checking your condition and your maintenance dose is determined [standard daily dose: 4-12 tablets (1.5-4.5mg)]. The dosage may be adjusted according to your age and the severity of symptoms, but the maximum daily dose should not exceed 12 tablets (4.5mg). Strictly follow the instructions.
•This medicine is to be swallowed whole, not chewed since the side effects are possibly developed to be taken by breaking or crunching of the tablets.
•If you miss a dose, take a dose as soon as you remember. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so. It may cause side effects when you rapidly decrease the dosage amount or when you stop taking the medicine.
Precautions while taking this medicine
•Do not engage in driving a car, operating machinery, working at high places or engaging in other hazardous activities. This medicine may cause drowsiness or sudden onset of sleep without warning signs, etc.
•Avoid drinking alcohol since it may increase the effects of this medicine.
Possible adverse effects of this medicine
The most commonly reported adverse reactions include somnolence (clouding of consciousness and almost sleeping state), nausea, dizziness, constipation and dry mouth. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•sudden onset of sleep without warning signs [sudden onset of sleep]
•seeing or hearing something that is not really there, baseless and subjective thought, having trouble thinking clearly[hallucination, delusion, delirium, confusion, agitation]
•convulsion, disturbance of consciousness[syndrome of inappropriate secretion of antidiuretic hormone (SIADH)]
•fever, strong muscle stiffness, clouding of consciousness[syndrome malin]
•lassitude, muscle pain, brown urine[rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from heat and moisture.
•Discard unused medicine. Ask the pharmacy or medical institutions how to discard.