部份中文施普善处方资料（仅供参考）
通用名：脑蛋白水解物注射液
商品名：施普善
英文名：CerebroproteinHydrolysateInjection
药理作用
1.具有与天然神经生长因子相同的作用，维持神经细胞存活，诱导神经元分化，促进神经突触形成。
2.调节脑组织代谢，提高葡萄糖利用率，增加蛋白质合成。
3.降低缺血、缺氧时脑内乳酸和自由基形成。
4.抑制钙离子内流和兴奋氨基酸的神经毒性作用。
5.减轻外伤或毒性物质造成的脑组织损害。
6.提高突触的兴奋性、增强学习、记忆能力。
适应证
1.早老性痴呆、血管性痴呆。
2.缺血、出血性性中风的急性和康复期治疗。
3.脑外伤，神经外科手术后。
4.缺血、缺氧性脑病（新生儿窒息，CO中毒）。
5.病毒、细菌性脑炎的辅助治疗。
6.脑发育不良、脑瘫的辅助治疗。
7.健忘，注意力障碍。
用法和用量
静脉点滴：20-30ml加入250-500ml5%葡萄糖液或生理盐水中静脉点滴，急性病例可加大到50ml，日一次，每周5-6次，4周为一疗程。
肌肉注射：每次2-5ml，每日一次。
儿童用量酌减。
不良反应
施普善已在50多个国家广泛使用，没有发现有明显副作用或抗药性。
禁忌证
过敏体质，癫痫或痉挛发作，严重肾功能衰竭时禁用或慎用。
施普善（Cerebrolysin®）
施普善®是一种生物技术制备的肽制剂，能刺激中枢神经系统的神经营养调节。
施普善®在世界范围内广泛用于治疗缺血性与出血性卒中、创伤性颅脑损伤，也能用于治疗各种形式的痴呆（血管性痴呆与阿尔茨海默病）以及认知障碍，能够防止脑损伤后的认知衰退。
施普善®的神经保护与神经再生功能对急性或退行性神经疾病患者颇有裨益。
施普善®的肌内注射剂量可高达5毫升，静脉注射剂量可高达10毫升。如果需要更高剂量，则建议采用静脉输液（输注时间：15—60分钟）。
Cerebrolysin® 1mlx10 vials
Cerebrolysin® 5ml x 5ampules
Cerebrolysin® 10ml x 5via
Cerebrolysin®:
Cerebrolysin® is recommended in cases of organic brain dysfunction, metabolic and neurodegenerative especially senile dementia of the Alzheimer type.
In cases of post-stroke complications Cerebrolysin® will speed up the recovery period.
Head trauma, post-operative cerebral contusion or concussion require Cerebrolysin®.
Cerebrolysin® active compound: Hydrolyzed protein of porcine brain.
Cerebrolysin® ingredients:
1 (one) ml solution  for injection/infusion containing hydrolysed protein from porcine brain in the form of concentrated solution, 215.2 mg and excipients: sodium hydroxide, water for injections.
Cerebrolysin® contraindications
- Hypersensitivity to the hydrolyzate of porcine brain protein or any of the excipients.
- Epilepsy
- Severe renal impairment.
Adverse reactions:
In rare cases, Cerebrolysin® treatment effects were associated with:
- Agitation (aggression, confusion, insomnia)
- Hyperventilation, hypertonia, hypotonia, fatigue, tremor, depression, apathy, dizziness and flu symptoms (eg colds, cough, upper respiratory tract infections).
During treatment with Cerebrolysin® reported one case of attack type "grand mal" seizures and
- Gastrointestinal disorders such as loss of appetite, dyspepsia, diarrhea, constipation, vomiting and nausea
- If too rapid injection may be a sensation of warmth or sweating, dizziness and, in isolated cases, palpitations or arrhythmias
- Local reactions at the injection site, such as irritation, itching or burning sensation
- In rare cases have been observed hypersensitivity or allergic reactions such as skin reactions, local reactions vascular headache, neck pain, pain in limb, fever, back pain, chills and shock.
Cerebrolysin® is used in the elderly because the side effects mentioned above are typical for this population and can be observed in the absence of drug use.
Directions to use the Cerebrolysin® :
May be given single doses up to 50ml/BW (10,760 mg of Cerebrolysin®) but cures treatment is preferable.
A cure best treatment involves administering Cerebrolysin® daily for 10-20 days.
Recommended Cerebrolysin® daily dose:
- Organic brain dysfunction, metabolic and neurodegenerative (dementia) is recommended daily dose of 5-30 ml / BW (1076-6456 mg of hydrolyzed porcine brain protein).
- Complications post - stroke: the recommended daily dose is 10-50 ml/BW (2152-10760 mg of Cerebrolysin®).
- Head trauma, post-operative cerebral contusion or concussion:
Recommended daily dose of 10-50ml/BW (2152-10760 mg of
Cerebrolysin®).
- Children: The recommended daily dose is 1-2 ml/BW (215.2 to 430.4 mg of Cerebrolysin®).
Cerebrolysin® efficacy can be increased by repeating cures, until no longer see improvements in your health.
After the initial cure, Cerebrolysin® dose frequency can be reduced to 2-3 times a week.
Must be left free intervals between courses, their duration is equal to the cure.
May be given doses up to 5 ml/BW (1076 mg of Cerebrolysin®) and intramuscularly to 10 ml/BW (2152 mg of Cerebrolysin®) intravenously.
Larger doses of 10-50 ml /BW (2152 up to a max. of 10,760 mg of
Cerebrolysin®) are recommended only as a slow intravenous infusion after
Cerebrolysin® dilution with infusion solutions recommended standard.
The infusion must be between 15 and 60 minutes.
The following standard Cerebrolysin® infusion solutions were tested for 24 hours at room temperature in the presence of light and were declared compatible:
- Sodium chloride solution 0.9% (9 mg Naci/ml)
- Ringer solution (Na 153.98 mmol/l, Ca 2.74 mmol/l, K> 4.02 mmol/l, Cl 163.48 mmol/l)
- Glucose 5%
Vitamins and cardiovascular drugs can be administered concomitantly with Cerebrolysin®, but should not be mixed in the syringe.
Cerebrolysin® is not addictive and doesn't requires special precautions.
Animal studies have shown reproductive toxicity. However, no studies have been performed in humans.
Thus, during pregnancy and breastfeeding Cerebrolysin® should be used only after careful eva luation of the risk / benefit.
Please avoid to buy Cerebrolysin® from unreliable sellers or manufacturers because it is a very sensitive product and an expired lot could lead to more damage than actual support.
The original brand name Cerebrolysin® is Made in Austria.
Cerebrolysin® box of 5 brown glass vials with breaking point 10ml solution for injection/infusion.
•Manufactured by:
EVER Neuro Pharma GmbH Austria