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Starsis Tablets 100×90mg(Nateglinide 那格列奈片)
药店国别  
产地国家 日本 
处 方 药: 是 
所属类别 90毫克/片 100片/盒 
包装规格 90毫克/片 100片/盒 
计价单位: 盒 
生产厂家中文参考译名:
安斯泰来
生产厂家英文名:
Astellas Pharma Inc.
该药品相关信息网址1:
http://www.info.pmda.go.jp/go/pack/3969006F1020_1_23/
该药品相关信息网址2:
该药品相关信息网址3:
原产地英文商品名:
Starsis(スターシス錠)90mg/Tablets 100Tablets/box
原产地英文药品名:
Nateglinide
中文参考商品译名:
Starsis(スターシス錠)90毫克/片 100片/盒
中文参考药品译名:
那格列奈
曾用名:
简介:

 

部份中文那格列奈处方资料(仅供参考)
商品名:Starsis Tablets
英文名:Nateglinide
中文名:那格列奈片
生产商:安斯泰来制药
药品简介
Starsis(Nateglinide)属于新一代促胰岛素分泌剂,可与其他各类口服降糖药物及基础胰岛素联合使用。2型糖尿病一线用药. 
スターシス錠30mg/スターシス錠90mg
药物类别名称
速效后低血糖剂
批准日期:1999年8月
商標名
Starsis Tablets 30mg
Starsis Tablets 90mg
一般名
ナテグリニド(Nateglinide)
化学名
N -[trans -4-(1-Methylethyl)cyclohexanecarbonyl]-D-phenylalanine
構造式
分子式
C19H27NO3
分子量
317.42
性状:
内特林化物是一种白色结晶粉末。易溶于甲醇或乙醇(99.5),不易溶解,不易溶于水。它溶解在一种罕见的氢氧化钠测试溶液中。观察到晶体多态性。
药用药理学
1. 血糖上升抑制作用
(1)60mg在6健康成年男性每天3次,每次饭前口服7天,促进每餐后早期胰岛素分泌,抑制血糖升高。
(2)对GK大鼠和新生儿链球菌素诱导(nSTZ)糖尿病模型大鼠的非肥胖2型模型动物进行口服丁二氰胺时,提高受损的胰岛素分泌反应和葡萄糖耐受性(体内)。
(3)口服对正常大鼠服用丁二氰胺时,各种碳水化合物(葡萄糖、蔗糖、淀粉、乳糖和混合糖溶液)抑制口服后血糖增加,在给给后2小时内(体内)恢复到控制值。
(4)口服对正常大鼠的丁二氰胺时,促进蔗糖口服后15-30分钟的早期胰岛素分泌(体内)。
2. 作用机制
Nateglynido 增强胰腺+细胞,促进胰岛素分泌(体外)
适应症
2型糖尿病后血糖变化的改善
然而,只有当在以下任何一种治疗方法中不能取得足够的效果时。
1. 仅限饮食和运动治疗
2. 除饮食和运动疗法外,使用β-葡曲酶抑制剂
3. 除饮食和运动疗法外,使用大营养药物
4. 除饮食和运动疗法外,使用基于三聚一苯的药物治疗
用法与用量
成年人;口服一次90mg,每餐前一天三次。在效果不足的情况下,可以在充分观察课程的同时,将量增加到120mg。
临床表现
对于1.2型糖尿病患者,一旦90mg,在双盲比较试验口服12周,就在每天三餐之前,后方血糖2小时值减少到185.9mg/dL后给药从234.4mg/dL给药(减少量平均:48.5mg/dL)。此外,HbA1c(JDS) 值从给政前的7.36%降至给政后的6.68%(平均减少金额:0.69%)。
此外,一年的长期分期试验确认效果延续,获得稳定的血糖控制。
2.对于使用β-葡萄糖酶抑制剂治疗的2型糖尿病患者,在每天三餐前口服10周,在组合施用215.4mg/dL后2小时,组合施用158.9mg/降至 dL(平均下降: 56.5mg/dL)。 此外,HbA1c (JDS)值从组合管理前的7.14%降低到组合管理后的6.50%(平均减少金额:0.63%)。
3. 对于2型糖尿病患者在治疗期间使用大肠药物,一次90mg,在双盲组合测试中口服12周,就每一天三餐前,后方血糖2小时值179.2mg后组合施用从252.6mg/dL联合前组合 下降到dL(平均减少量:73.5毫克/分升)。此外,HbA1c(JDS)值从组合管理前的 7.52% 降至组合管理后的 6.73%(平均减少金额:0.76%)。
此外,对一年的长期分药试验证实了该效果的延续性,取得了改善产后稳定葡萄糖转化的效果。
4. 对于2型糖尿病患者在治疗期间使用三聚氨酸为基础的药物(盐酸皮奥利他酮),在双盲组合测试中口服24周,就在每天3餐一次90mg之前,在组合前2小时,在254.6mg/在组合给给后,从dL减少到201.9mg/dL(平均减少量:48.0mg/dL)。此外,HbA1c(JDS)值从组合管理前的7.41% 降至组合管理后的6.94%(平均减少金额:0.47%)。
此外,一年的长期分期试验确认效果延续,获得稳定的血糖控制。
包装
片剂
30毫克:100片(10片x10)、210片(21片x10)、500片(10片x50)
90毫克:100片(10片x10)、210片(21片x10)、500片(10片x50)、1,050片(21片x50)
制造供应商
安斯泰来制药公司
注:以上中文处方资料不够完整,使用者以原处方资料为准。
完整资料附件:
http://www.info.pmda.go.jp/go/pack/3969006F1020_1_23/
Starsis Tablets 90mg(Nateglinide)
Brand name:Starsis Tablets 90mg
Active ingredient:Nateglinide
Dosage form:pink tablet (φ: 8.1mm, thickness: 4.4mm)
Print on wrapping:(Face) 糖尿病の薬, 食直前に服用, スターシス 90, (Back) 糖尿病
の薬, スターシス 90mg, house-mark
Effects of this medicine
This medicine suppresses postprandial hyperglycemia (elevation in the blood glucose level after a meal) bystimulating beta cells in the pancreas to promote insulin secretion.
It is usually used for the treatment of diabetes mellitus.
Before using this medicine, be sure to tell your doctor and pharmacist
・If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you have ketosis, diabetic coma or precoma, insulin-dependent diabetes mellitus, renal disorder, or infections.
If you are in a pre- or post-operative state.
If you have any injury.
・If you are pregnant or breastfeeding.
・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinaleffects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
・Your dosing schedule prescribed by your doctor is<< to be written by a healthcare professional>>
・General dosage regimen: For adults, take 1 tablet (90mg of the active ingredient) at a time, 3 times daily, beforeeach meal (within 10 minutes). If the effect is insufficient, the dosage may be increased up to 120mg at a time whileobserving your clinical course. As this preparation contains 90mg of the active ingredient per tablet, take thispreparation when you take at least 90mg at a time according to the above dosage regimen. Strictly follow theinstructions of your doctor/pharmacist.
・If you realize that you have missed a dose after starting a meal, skip the missed dose and take the usual dose beforethe next meal. DO NOT take double doses to make up for the missed dose. (It may cause hypoglycemic conditions).
・If you took too much of the medicine (more than ordered), check with your doctor/pharmacist. If you have dizzinessor light-headedness due to lowering of blood glucose (hypoglycemia), take something that contains glucose, suchas sugar or juice, or glucose if you are concomitantly taking an alpha-glucosidase inhibitor (acarbose or voglibose),before consulting with your doctor.
・Do not stop taking the medicine without the instructions of your doctor.
Precautions while taking this medicine
・Share better understanding with your family about your diabetes mellitus.
・Take meals regularly and avoid excessive eating and drinking.
・The medicine may cause dizziness or light-headedness due to hypoglycemia. Pay close attention when you drive acar, work at heights, or operate dangerous machinery.
・Take something that contains glucose, such as sugar or juice, if you have dizziness or light-headedness due tohypoglycemia. Take glucose, if you are concomitantly taking an alpha-glucosidase inhibitor (acarbose orvoglibose).
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: queasy,increased flatus, bloating, diarrhoea, abdominal pain, rash, itching, urticaria, erythema multiforme, headache,dizziness, malaise, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicatedin brackets. If any of these symptoms occur, stop taking this medicine and see your doctorimmediately.
・cold sweat, chills, palpitations [hypoglycemia]
nternal
Revised: 06/2011
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approvaldetails may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It isimportant to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response,
patients should understand their medication and cooperate with the treatment. 

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