部份中文西格列汀二甲双胍处方资料（仅供参考）
通用名：西格列汀二甲双胍片、磷酸西格列汀二甲双胍缓释片
英文名：Sitagliptin Phosphate /metformin Hydrochloride
商品名：JANUMET XR,JANUMET
主要成分信息：
磷酸西格列汀
英文名称：Sitagliptin Phosphate
化学名称：7-[(3R)-3-氨基-1-氧-4-(2，4，5-三氟苯基)丁基]-5，6，7，8-四氢-3-（三氟甲基）-1，2，4-三唑酮[4，3-a]吡嗪磷酸盐(1：1)一水合物
结构式
分子式：C16H15F6N5O•H3PO4•H2O
分子量：523.32
盐酸二甲双胍
英文名称：Metformin Hydrochloride
结构式
分子式：C4H11N5•HCl
分子量：165.63
国内外上市情况
西格列汀为口服二肽基肽酶-4（DPP-4）抑制剂，2006年10月默克公司获得FDA批准用于治疗Ⅱ型糖尿病。商品名为“JANUVIA”剂型为片剂，规格为25mg、50mg、100mg。西格列汀为DPP-4抑制剂 类降糖药的第一个产品。2007年3月30日默克公司的西格列汀二甲双胍片固定剂量组合制剂“JANUMET”获批上市；2012年2月2日默克公司开发的西格列汀二甲双胍缓释片“JANUMET XR”获批上市，规格有：50mg/500mg, 50mg/1000mg, and 100mg/1000mg。我国CFDA于2012年10月23日批准西格列汀片进口，商品名：“捷诺维”规格为：25mg、50mg、100mg；CFDA于2013年3月批准西格列汀和二甲双胍的复方制剂进口上市，商品名：“捷诺达”，规格为50mg/500mg，50mg/850mg。
作用机理
（1）西格列汀
西格列汀为DPP-4抑制剂，主要通过减慢肠促胰岛素激素的失活速度而发挥作用，通过增加肠促胰岛素激素的活力而使胰岛素释放增加，并降低循环中胰高血糖素的水平，从而达到降糖作用。西格列汀选择性作用于DPP-4，治疗剂量下，对DPP-8 和DPP-9无抑制作用。
（2）盐酸二甲双胍
盐酸二甲双胍为双胍类口服降血糖药，用于Ⅱ型糖尿病。可以同时抑制基础血糖和餐后血糖。具有多种作用机制，包括延缓葡萄糖由胃肠道的摄取，通过提高胰岛素的敏感性而增加外周葡萄糖的利用，以及抑制肝、肾过度的糖原异生。本品不降低非糖尿病患者的血糖水平。患者用药期间体重通常减轻、血浆胆固醇、甘油三酯和前β脂蛋白水平可降低，外周葡萄糖代谢能得到改善。 
JANUMET (JAN-you-met) tablets contain 2 prescription medicines:sitagliptin (JANUVIA®) and metformin.
JANUMET can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. Your doctor will determine whether JANUMET is right for you.
JANUMET should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET.
Selected Risk Information About JANUMET
Metformin, one of the ingredients in JANUMET, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Stop taking JANUMET and call your doctor right away if you get any of the following symptoms of lactic acidosis: you feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; have unusual sleepiness or sleep longer than usual; have sudden stomach or intestinal problems with nausea and vomiting or diarrhea; feel cold, especially in your arms and legs; feel dizzy or lightheaded; or have a slow or irregular heartbeat.
You have a higher chance of getting lactic acidosis if you have kidney problems, liver problems, or congestive heart failure that requires treatment with medicine; if you drink alcohol very often, drink a lot of alcohol in a short period of time, or get dehydrated(lose large amounts of body fluids); if you have certain x-ray tests with dyes or contrast agents that are injected into your body; if you have surgery, a heart attack, severe infection, or stroke; or if you are 80 years or older and have not had your kidneys tested.
Pancreatitis is another serious side effect that can happen in people taking JANUMET. Pancreatitis may be severe and lead to death.
Before you start taking JANUMET, tell your doctor if you’ve ever had pancreatitis. Stop taking JANUMET and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.
Do not take JANUMET if you are allergic to any of the ingredients in JANUMET. Allergic reactions, which may be serious, including rash; hives; and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have an allergic reaction, stop taking JANUMET and call your doctor right away.
Do not take JANUMET if you are going to receive an injection of dye or contrast agent for an x-ray procedure or if your kidneys are not working properly. Your doctor will do blood tests before and during your treatment with JANUMET to see how well your kidneys are working.
If you take JANUMET with another medicine that can cause low blood sugar (hypoglycemia), such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher.
The dose of your sulfonylurea or insulin may need to be lowered. Signs and symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heart beat, sweating, and feeling jittery.
Kidney problems, sometimes requiring dialysis, have been reported.
Common side effects when taking JANUMET include stuffy or runny nose and sore throat, upper respiratory tract infection, diarrhea, nausea and vomiting, gas, upset stomach, indigestion, weakness, and headache.
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