部份中文地奈德处方资料（仅供参考）
通用名称：地奈德洗剂
英文名称：Desonide
商品名称：DESONIDE 0.05%
药物分类: 肾上腺皮质激素
成份: Desonide
适应症:
本品为中弱效皮质类固醇，可减轻皮质类固醇治疗有效的皮肤病的炎症和瘙痒反应。
规格: 0.05%(W/W)
用法用量:
将本品在患处涂一薄层，根据患病严重程度，每日二至三次。使用前充分振摇本品。与其他皮质类固醇合用时，当症状得到控制，应停用本品，如使用本品后二周内症状无改善，应另行诊断。本品不应使用封包疗法。
不良反应:
在临床对照试验中，与地奈德有关的不良反应发生率约8%，其中：刺痛和灼热感约占3%；刺激，接触性皮炎、病情加重、脱皮、痒、暂时性红斑和干燥/脱屑各少于2%。另外，有报道下列局部不良反应在外用其他皮质类固醇时偶有发生。而且多发生在封包疗法中，特别是用强效皮质类固醇时。这些不良反应按发生顺序依次递减为：毛囊炎、痤疮样皮疹、色素减退、口周皮炎、继发感染、皮肤萎缩、萎缩纹和痱子。
禁忌:
本品禁用于对该制剂中任何成份过敏者。
注意事项:
概述：系统外用皮质类固醇吸收后可产生可逆性下丘脑-垂体-肾上腺轴（HPA）抑制，从而可能产生停药后糖皮质激素不足。外用皮质类固醇治疗过程中系统吸收可引起柯兴氏综合征、高血糖和尿糖。患者大面积外用或封包外用时应定期检查HPA轴的抑制情况。可通过ACTH刺激试验、检测早上血浆可的松水平和尿游离可的松水平来判断。
外用超强效皮质类固醇一次不能超过2周，并只能小面积使用，否则可能增加HPA轴抑制的危险。如果发现HPA轴的抑制，应当停药，减少用药次数或用相对弱效的皮质类固醇替代治疗。当停止外用皮质类固醇后，HPA轴的功能一般很快完全恢复。偶尔，当出现皮质类固醇缺乏的体征和症状时，需要系统补充皮质类固醇。
关于系统补充皮质类固醇的方法请参照有关产品说明书。儿童患者因体表面积与体重之比更大，所以对同等剂量的皮质类固醇其系统毒性更敏感（参照注意-婴幼儿和儿童）。如果发生刺激，应当停用本品，并给予适当治疗。皮质类固醇引起的接触过敏性皮炎通常根据治疗无效而判断，而不是如多数外用非皮质激素药物那样根据病情加重来判断。
皮质类固醇引起的接触过敏性皮炎的诊断应当用斑贴试验证实。如果并发皮肤感染，应当使用适当的抗真菌或抗细菌药物。如果抗感染药物没有很快起效，应当停用本品，直至感染被完全控制。
患者须知：患者在使用外用皮质类固醇药物时应当得到下列忠告和指导：
1．本药只能在医生指导下使用，并且只能外用，避免接触眼睛。
2．本药不能用于处方以外的其他疾病。
3．如果没有医生指导，用药局部皮肤不能包扎、覆盖或封包。
4．患者应当向医生报告任何局部不良反应。
孕妇及哺乳期妇女用药: 孕妇,致畸作用： 对孕妇的影响为C级。
体内服用低剂量皮质类固醇药物对试验动物有致畸性。某些皮质类固醇药物用于皮肤时对试验动物有致畸性。没有关于本品对动物生育力影响的研究。尚不知道孕妇使用本品后是否对.
儿童用药:
儿童的安全性和有效性尚未研究。因为儿童的体表面积与体重之比更大，当外用皮质类固醇激素时，儿童出现HPA轴抑制的危险性比成人更高。儿童在停药后出现糖皮质激素不足或治疗中发生柯兴氏综合征的危险性更高。
药物过量: 过量外用本品可引起体内反应（见注意事项）。
毒理研究:
与其他外用皮质类固醇相同，地奈德有抗炎、止痒和血管收缩的特性。外用皮质类固醇的抗炎活性机制仍不清楚。不过，皮质类固醇被认为通过诱导磷酸脂酶A2抑制蛋白（统称脂皮质素）的产生而起到抗炎作用。
药代动力学:
外用皮质类固醇的透皮吸收是由基质和表皮屏障功能的完整性等许多因素决定的。外用氢化可的松封包24小时未证明透皮吸收增加，然而封包96小时透皮吸收明显增加。外用皮质类固醇可被正常完整皮肤吸收。在炎症和/或...
性状: 本品为白色或类白色乳状粘稠液体。
贮藏: 保存于2-30oC
有效期:
18个月
Desonate(desonide) Gel 0.05%
Desonate(desonide) Gel 0.05% is a prescription medication used to treat mild to moderate atopic dermatitis (a certain type of eczema) in patients 3 months of age and older.
Use Desonate® for the minimum amount of time as necessary to achieve the desired results because of the potential for Desonate® to suppress the levels of certain hormones in the body (a condition called hypothalamic-pituitary-adrenal (HPA) axis suppression). You should not use Desonate® for more than 4 consecutive weeks.
Indication & Usage
Desonate® (desonide) Gel 0.05% is a prescription medication used to treat mild to moderate atopic dermatitis (a certain type of eczema) in patients 3 months of age and older.
Use Desonate® for the minimum amount of time as necessary to achieve the desired results because of the potential for Desonate® to suppress the levels of certain hormones in the body (a condition called hypothalamic-pituitary-adrenal (HPA) axis suppression). You should not use Desonate® for more than 4 consecutive weeks.
Important safety information
Do not use Desonate® if you have a history of hypersensitivity to any of the ingredients in Desonate®.
Drugs like Desonate® may reduce the levels of certain hormones in the body (a condition called reversible hypothalamic-pituitary-adrenal (HPA) axis suppression) which may cause a decrease in certain steroids normally produced in the body, a condition called Cushing’s syndrome, high blood sugar and/or unmasking of hidden diabetes. Your doctor will periodically check you for signs of HPA axis suppression. If you do experience HPA axis suppression, your doctor will either gradually take you off Desonate®, reduce how many times a day you apply it, or switch you to another drug that is not as strong. Tell your doctor if you are using any other corticosteroid topical drugs like Desonate® as it may increase your risk of experiencing HPA axis suppression.
Pediatric patients may be more likely to experience these side effects from Desonate® use. Unless your doctor tells you to do so, do not use Desonate® on the underarm or groin area of children. Do not use to treat skin irritation from diaper use. Use in children less than 3 months of age is not recommended.
You may be more likely to experience local adverse reactions on the skin if you use tight bandages or dressings, use Desonate® for a long period of time, or use other strong corticosteroid drugs. These reactions may include thinning of the skin, stripes, small dilated blood vessels on the skin, burning, itching, irritation, dryness, infection of the hair follicles, an inflammatory form of acne (acneiform eruptions), loss of skin color, rash around the mouth, allergic contact dermatitis, secondary infection, and heat rash. Some of these reactions may be permanent.
If you have or develop a skin infection while using Desonate®, tell your doctor and seek medical treatment. If your infection does not resolve, stop using Desonate® until the infection is controlled.
If irritation develops, stop using Desonate® and talk to your doctor about appropriate treatment.
The most common adverse reactions with Desonate® are headache, application site burning, and rash.
Desonate® is for topical use only. Not for ophthalmic, oral or intravaginal use. As with other corticosteroids, Desonate® should be stopped when control is achieved.
See Full prescribing information for Desonate®.