See Available Brands of Latanoprost in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes (through the uvealsclearal tract).

It is also known by the brand name of Xalatan manufactured by Pfizer. Annual sales are approximately $1.6 billion. The patent for latanoprost expires in 2011.

Pharmacodynamics

Information Not Available

Pharmacokinetics

Latanoprost, a synthetic analogue of prostaglandin F2a, reduces the IOP by increasing the outflow of aqueous humour.

Absorption
Absorbed through the cornea; peak concentration in the aqueous humour is reached around 2 hours after administration.

Metabolism
Rapidly hydrolised to biologically active latanoprost acid by esterases in the cornea.

Excretion
Via urine.

Latanoprost Indications / Latanoprost Uses

Information Not Available

Latanoprost Adverse Reactions / Latanoprost Side Effects

Brown pigmentation particularly in those with mixed-color irides; blepharitis, ocular irritation and pain; darkening, thickening and lengthening of eyelashes; localised oedema; conjunctival hyperaemia; transient punctate epithelial erosions; dyspnoea; exacerbation of asthma; local skin reactions; iritis; uveitis; darkening of palpebral skin.

Precautions

Special Risk Patients
Use caution in patients with active intraocular inflammation (eg, iritis, uveitis).

Eye pigmentation
Changes to pigmented tissue (eg, iris, periorbital tissue [eyelid], eyelashes) may occur.

Macular edema
Macular edema, including cystoid macular edema, may occur.

Special Precautions

Do not use within 5 minutes of thiomersal-containing preparations. Aphakia or pseudophakia with torn posterior lens cap or anterior chamber lenses; risk factors for cystoid macular oedema; brittle or severe asthma; history of intraocular inflammation; inflammatory, neovascular, angle-closure or congenital glaucoma; pregnancy, lactation. Remove contact lenses during use.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Ophthalmic
Ocular hypertension, Open-angle glaucoma
Adult: Instil 1 drop of a 0.005% solution once daily in the evening.

Food(before/after)

Information Not Available

List of Contraindications

Latanoprost and Pregnancy

Caution when used during pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Latanoprost and Lactation

Caution when used during lactation

Latanoprost and Children

Safety and efficacy not established

Latanoprost and Geriatic

Information Not Available

Latanoprost and Other Contraindications

Information Not Available

Storage

Ophthalmic
Store unopened at 2-8°C and at <25°C for up to 6 weeks after opening.

Lab interference

Information Not Available