See Available Brands of Latanoprost + Timolol in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Latanoprost is an analogue of prostaglandin F2α; it reduces intraocular pressure (IOP) by increasing outflow of aqueous humour. Timolol is a non-selective adrenergic blocker. It lowers IOP by decreasing the formation of aqueous by the ciliary epithelium.

Pharmacodynamics

Pharmacokinetics
Latanoprost is an analogue of prostaglandin F2α; it reduces intraocular pressure (IOP) by increasing outflow of aqueous humour. Timolol is a non-selective adrenergic blocker. It lowers IOP by decreasing the formation of aqueous by the ciliary epithelium.

Absorption
Latanoprost: Well-absorbed through the cornea; a prodrug that is activated by the esterases in the cornea.

Distribution
Latanoprost: Active metabolite has a small volume of distribution of 0.16 L/kg and protein binding of 87%.

Metabolism
Latanoprost: Active metabolite is mainly metabolised hepatically. Timolol: Largely metabolised in the liver.

Excretion
Latanoprost: Plasma half-life of active metabolite is about 17 minutes and the metabolites are excreted primarily in the urine. Timolol: Plasma half-life is about 6 hours and the metabolites are mainly excreted in the urine.

Latanoprost + Timolol Indications / Latanoprost + Timolol Uses

Information Not Available

Latanoprost + Timolol Adverse Reactions / Latanoprost + Timolol Side Effects

Increased iris pigmentation, eye irritation, eye pain, stinging and burning sensation. Rarely, bradycardia, arrhythmia, CHF, bronchospasm and allergic reactions.

Precautions

Symptoms of systemic timolol overdose: Bradycardia, hypotension, bronchospasm and cardiac arrest. Treatment is symptomatic and supportive. Latanoprost overload can cause ocular irritation and conjunctival hyperaemia, no other ocular or systemic side effects are known. If latanoprost is accidentally ingested orally, gastric lavage may be used. Treatment is symptomatic and supportive.

Special Precautions

Monitor heart rate and signs of cardiac failure in patients with history of severe cardiac disease. May worsen Prinzmetal angina, severe peripheral and central circulatory disorders and hypotension. Monitor for signs of bronchospasm in asthmatic patients. β-blockers may mask signs and symptoms of acute hypoglycaemia and hyperthyroidism. Prolonged treatment with latanoprost may change eye colour by increasing the amount of brown pigment in the iris especially in patients with mixed coloured irides; regular eye examination is recommended. Caution when used in aphakic patients due to risk of macular oedema. Contact lenses should be removed during application and reinserted at least 15 minutes after application. May cause transient blurring of vision; patients should not drive or operate machinery until this resolves. Pregnancy and lactation.

Other Drug Interactions

Additive effect on the intraocular pressure and other systemic effects may occur when used with oral β-blockers, calcium channel blockers, guanethidine, antiarrhythmics, digitalis glycosides or parasympathomimetics. Concurrent use of ≥2 ophthalmic prostaglandin analogues may lead to paradoxical increase in intraocular pressure. Mydriasis may occur when used concurrently with epinephrine. β-blocker may increase hypoglycaemic effect of antidiabetic agents.

Other Interactions

Information Not Available

Dosage

Ophthalmic
Open-angle glaucoma, Ocular hypertension
Adult: As eye preparation containing latanoprost 0.005% and timolol 0.5%: Instill 1 drop into the affected eye(s) once daily. Not to be used as an initial therapy.

Food(before/after)

Information Not Available

List of Contraindications

Latanoprost + Timolol and Pregnancy

Caution when used during pregnancy

Latanoprost + Timolol and Lactation

Caution when used during lactation

Latanoprost + Timolol and Children

Information Not Available

Latanoprost + Timolol and Geriatic

Information Not Available

Latanoprost + Timolol and Other Contraindications

Reactive airway diseases e.g.bronchial asthma or a history of bronchial asthma, severe COPD. Sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock.

Storage

Ophthalmic
Store at 2-8°C. For opened bottles, may store below 25°C.

Lab interference

Information Not Available