Effects of this medicine

Before using this medicine, be sure to tell your doctor and pharmacist

• If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  If you have bone marrow suppression (including leukopenia), renal/hepatic disorder, infectious disease, diabetes, gastrointestinal ulcers or hemorrhage.
  If you have a current or past history of interstitial pneumonia or heart disease.
  If you are using fluoropyrimidine-group drugs. (NKS-1 and fluropyrimidine-group drugs may interact strongly with each other and cause serious side effects.)
  If your medicine was switched from fluropyrimidine-group drugs to this medicine (NKS-1). (An appropriate washout period must be provided in consideration of the influence of these prior agents.)

• If you are pregnant, breastfeeding or possibly pregnant.

• If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

• Your dosing schedule prescribed by your doctor is <<        to be written by a healthcare professional>>

• In general, for adults, the initial dose is determined based on body surface area as follows: 40 mg of Tegafur for patients with under 1.25 m2 of body surface area; 50 mg of Tegafur for patients with 1.25 to 1.5 m2 of body surface area; 60 mg of Tegafur for patients with over 1.5 m2 of body surface area. The medicine is administered twice daily after breakfast and dinner, for 28 consecutive days, followed by a 14-day rest. This is regarded as one course, which is repeated. The dose can be decreased or increased according to the patient's condition in stages of: 40, 50, 60, or 75 mg. The maximum dose is limited to 75 mg at a time, and the minimum dose is 40 mg at a time. This medicine contains 25 mg of Tegafur in a capsule. Strictly follow the instructions.
• This medicine must NOT be taken with other fluoropyrimidine-group anticancer drugs.
• Record your drug consumption, your physical condition and symptoms, and show your records to your physician or pharmacist on your next visit.

• If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.

• If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.

• Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

• During the treatment, laboratory tests (hematological, liver and renal function tests) are performed regularly at least once every 2 weeks to detect asymptomatic side effects as early as possible. Be sure to keep your visiting schedule.

Possible adverse reactions to this medicine

• bleeding tendency, dullness, fever, sore throat [bone marrow depression, haemolytic anaemia]
• yellowness in the skin, dullness, yellowness in the whites of the eyes, loss of appetite [serious liver disorder]
• diarrhea, severe stomachache [serious enteritis]
• breathlessness, fever, dry cough [interstitial pneumonia]
• sore in the mouth, blood in stool, darkened stool, hematemesis, stomachache  [serious stomatitis, gastrointestinal ulceration, gastrointestinal hemorrhage, gastrointestinal perforation]
• severe stomatitis, red rash, redness of the eyelid/eye [toxic epidermal necrolysis, oculomucocutaneous syndrome]

Storage conditions and other information

• Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•  Discard the remainder. Do not store them. Ask the pharmacist or healthcare facility how to discard them.