INTELENCE Tablets 100mg（インテレンス錠100mg）
Brand name : INTELENCE Tablets 100mg
Active ingredient: Etravirine
Dosage form: white to slightly-yellowish white tablet, major axis 19 mm, minor axis 9.5 mm, thickness 6.6 mm
Print on wrapping: TMC125
Effects of this medicine
This medicine is a reverse transcriptase inhibitor that inhibits the action of DNA polymerase on human immunodeficiency virus type-1 (HIV-1) to slow disease progression.
It is usually used for treatment of HIV-1 infection in combination with other anti-HIV agents.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 2 tablets (200 mg of the active ingredient) at a time, twice daily after meals, definitely with concomitant other anti-HIV agents. Strictly follow the instructions.
•Do not miss any single dose because you lose its effect if you miss a dose. If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Avoid taking this medicine with food or beverage containing hypericum perforatum(Saint. John's wort). Because hypericum perforatum may decrease the blood concentration of this medicine and reduce the effect of it.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, diarrhea, and nausea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•high fever (38 degrees or higher), red eyes, erosive mouth/lips, red rash [toxic epidermal necrolysis, mucocutaneous-ocular syndrome, polymorphic erythema, hypersensitivity reaction with the rash of the whole body symptom (including drug hypersensitivity syndrome)]
•loss of appetite, dullness, nausea [hepatitis]
•decreased urination output, swelling, headache [renal failure, acute renal failure]
•muscle pain of limbs, stiffness, numbness [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them. If you dispose of unused medicines, seek advice of your pharmacist or medical institutionabout proper disposal of drugs.
JANSSEN PHARMACEUTICAL K.K.Internal
Revised: 7/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/6250033F1020_1_11/ |
