Effects of this medicine

Before using this medicine, tell your doctor/pharmacist

• If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
  If you are a patient with infections such as plural sepses or suspected of them.
  If you are a patient with tuberculosis or a history of it.
  If you are a patient with demyelinating disease such as multiple sclerosis or a personal or a family history of it.
  If you are a patient with hematologic disease or a hepatitis B virus carrier.
  If you have just received live vaccine.
  If you have congestive heart failure.

• If you are pregnant or breastfeeding.

• If you are using any other prescription or nonprescription (OTC) medicine. (It is important to reduce the risk of drug interactions.)

Dosage regimen (proper use of this medicine)

• Your dosage regimen is:(order of your doctor)

• General dosage regimen:
  For rheumatoid arthritis, for adults, the usual adult dosage is 1 syringe (40 mg of the active ingredient) per dose injected subcutaneously every two weeks. The dosage may be increased up to 80 mg at a time if the effect is insufficient.
  For psoriasis vulgaris, or psoriasis arthropica, for adults, the usual adult dosage is an initial dose of 2 syringes (80 mg of the active ingredient), followed by 1 syringe (40 mg of the active ingredient) per dose, injected subcutaneously every two weeks. The dosage may be increased up to 80 mg at a time if the effect is insufficient.
  For ankylosing spondylitis, for adults, the usual adult dosage is 1 syringe (40 mg of the active ingredient) per dose injected subcutaneously every two weeks. The dosage may be increased up to 80 mg at a time if the effect is insufficient.
  For crohn's disease, for adults, the usual adult dosage is an initial dose of 4 syringes (160 mg of the active ingredient), followed by 2 syringes (80 mg of the active ingredient) two weeks later from the initial dose, injected subcutaneously. Two weeks later begin 1 syringe (40 mg of the active ingredient) per dose, injected subcutaneously every two weeks.
  Strictly follow the instructions of your doctor/pharmacist.

• Injection site should be changed every time you inject the medicine. Do not inject to sensitive area of skin, wound site, skin rash or a psoriasis lesion. Do not massage the subcutaneous injection site.
• You need to inject in the area of at least 3 cm apart from the last injection site.

• Missed dose: Consult your doctor if you missed an injection.

• Overdose: If you injected too much of the medicine (more than ordered), check with your doctor/pharmacist.

• Others: Do not stop injecting the medicine without the instructions of your doctor.

Precautions while using this medicine

Side effects of this medicine

• chill, sudden high fever with shivering, cough, sputum [severe infections such as sepsis or pneumonia]
• prolonged slight fever or cough (2 weeks or over), general malaise, weight loss [tuberculosis]
• joint pain, muscular pain, skin eruption [lupus-like syndrome]
• reduced vision, double vision, numbness, pain, paralysis [demyelinating disease]
• breathing difficulty, urticaria, swelling around the eye or lip [severe allergic reaction]
• malaise, loss of appetite, yellowness in the skin and/or the white of the eye [fulminant hepatitis, hepatic dysfunction, jaundice, hepatic insufficiency]

Storage and other information

• Keep the medicine out of the reach of children. Store it away from light and freeze, at temperature of 2 to 8 ℃.
• Discard the remainder. Do not store them. Ask the pharmacist how to discard.