Vaxchora(Cholera Vaccine, Live, for Oral Administration)
VAXCHORA Rx
Generic Name and Formulations:
Cholera vaccine, live attenuated (V. cholerae strain CVD 103-HgR); 100mL per single dose; susp for oral administration after reconstitution.
Company:
PaxVax Corporation
Indications for VAXCHORA:
Immunization against disease caused by Vibrio cholerae serogroup 01 in adults 18–64 years of age traveling to cholera-affected areas.
Limitations Of use:
Efficacy not established in persons living in cholera-affected areas or persons with pre-existing immunity due to previous exposure to V. cholerae or receipt of a cholera vaccine. Not shown to protect against disease caused by V. cholerae serogroup 0139 or other non-01 serogroups.
Adult:
For oral administration only. Avoid food or drink for 60mins before and after administration. ≥18yrs: Give single oral dose a minimum of 10 days before potential cholera exposure.
Children:
<18yrs: not established.
Contraindications:
Severe allergic reaction to any previous cholera vaccine.
Warnings/Precautions:
Immunocompromised. Considering whether to administer to individuals with immunocompromised close contacts. Elderly. Pregnancy.
Interactions:
Avoid use within 14 days of systemic antibiotics. Give vaccine ≥10 days prior to antimalarial prophylaxis with chloroquine. Concomitant immunosuppressive therapy (eg, irradiation, antimetabolites, alkylating agents, cytotoxic drugs, high-dose corticosteroids): may get suboptimal response.
Pharmacological Class:
Cholera vaccine.
Adverse Reactions:
Tiredness, headache, abdominal pain, nausea/vomiting, lack of appetite, diarrhea.
Note:
To enroll patients in the pregnancy exposure registry call (800) 533-5899.
Generic Availability:
NO
How Supplied:
Single-dose carton—2 packets (buffer component + active component) |
