HECTOROL Rx
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HECTOROL
Secondary hyperparathyroidism/hypocalcemia  Only 4 drugs may be compared at once

Generic Name and Formulations:
Doxercalciferol 0.5mcg, 1mcg, 2.5mcg; caps.
Company:
Genzyme Corporation
 
Select therapeutic use: Secondary hyperparathyroidism/hypocalcemia
Indications for HECTOROL:
Secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on dialysis. Predialysis patients with Stage 3 or 4 CKD (oral form only).

Adult:
Dialysis: initially 10mcg three times weekly at dialysis; adjust to maintain intact parathyroid hormone (iPTH) between 150–300pg/mL; max 20mcg three times weekly. Predialysis: initially 1mcg once daily; adjust by 0.5mcg at 2-week intervals to target iPTH levels; max 3.5mcg/day.

Children:
Not established.

Contraindications:
Hypercalcemia. Vit.D toxicity. Concurrent other forms of Vit.D.

Warnings/Precautions:
Maintain appropriate calcium, phosphate, fluid intake. Keep serum calcium times phosphate product (Ca × P) <55 in CKD patients or <70 in patients with elevated iPTH. Monitor iPTH, serum calcium, phosphorus (dialysis: at baseline and weekly during titration, then periodically; predialysis: every 2 weeks for 3 months during titration, then monthly for 3 months, then every 3 months). Adjust phosphate binder dose to maintain PTH suppression and serum calcium and phosphate levels. Hepatic impairment. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:
Hypermagnesemia with magnesium-containing antacids. Absorption reduced by mineral oil. May be antagonized by hepatic enzyme inducers (eg, phenobarbital).

See Also:
HECTOROL INJ

Pharmacological Class:
Vit. D analog.

Adverse Reactions:
Headache, malaise, GI upset, constipation, arthralgia, edema, dizziness, sleep disorder, dyspnea; Vit.D toxicity (eg, hypercalcemia, hypercalciuria, hyperphosphatemia, adynamic bone diseases, arrhythmias, seizures); see literature.

How Supplied:
Caps—50
Inj (1mL, 2mL)—1