Generic Name and Formulations:
Gabapentin 100mg, 300mg, 400mg.
Company:
Pfizer Inc.
Indications for NEURONTIN CAPSULES:
Postherpetic neuralgia.
Adult:
300mg once on day 1, twice daily on day 2, and 3 times daily on day 3; may titrate up to usual max 1.8g/day in 3 divided doses (doses up to 3.6g/day have been used without added benefit). Renal dysfunction: CrCl 30–59mL/min: 400–1400mg/day in 2 divided doses; CrCl 15–29mL/min: 200–700mg once daily; CrCl ≤15mL/min: 100–300mg once daily (see full labeling); hemodialysis: 125–350mg after session.
Children:
Not established.
Warnings/Precautions:
Renal dysfunction. Suicidal behavior and ideation (monitor). Monitor for DRESS/multiorgan hypersensitivity, anaphylaxis, angioedema; discontinue if occurs. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Interactions:
Potentiates CNS depression with alcohol, morphine, other CNS depressants. Give 2 hrs after antacids. May antagonize hydrocodone. May interfere with some urine protein tests (eg, Multistix-SG).
See Also:
NEURONTIN TABLETS
NEURONTIN ORAL SOLN
Adverse Reactions:
Dizziness, somnolence, peripheral edema, nausea, ataxia, amblyopia, thought disorder, abnormal gait, incoordination.
How Supplied:
Caps, tabs—100; Soln—470mL
Indications for NEURONTIN CAPSULES:
Adjunct in partial seizures.
Adult:
Add or remove other AEDs over at least 1 week. Initially 300mg three times daily. Usual range: 900–1800mg/day in 3 divided doses; max 2.4g/day (up to 3.6g/day has been used short-term; see full labeling); max 12 hrs between doses. Renal dysfunction: CrCl 30–59mL/min: 400–1400mg/day in 2 divided doses; CrCl 15–29mL/min: 200–700mg once daily; CrCl ≤15mL/min: 100–300mg once daily (see full labeling); hemodialysis: 125–350mg after session.
Children:
<3yrs: not established. Give in 3 divided doses; max 12 hrs between doses; titrate over 3 days. 3–11yrs: initially 10–15mg/kg per day. 3–4yrs: titrate to 40mg/kg per day. ≥5yrs: titrate to 25–35mg/kg per day. Max 50mg/kg per day. Renal impairment: not studied.
Warnings/Precautions:
Renal dysfunction. Suicidal behavior and ideation (monitor). Monitor for DRESS/multiorgan hypersensitivity, anaphylaxis, angioedema; discontinue if occurs. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Interactions:
Potentiates CNS depression with alcohol, morphine, other CNS depressants. Give 2 hrs after antacids. May antagonize hydrocodone. May interfere with some urine protein tests (eg, Multistix-SG).
See Also:
NEURONTIN TABLETS
NEURONTIN ORAL SOLN
Adverse Reactions:
Somnolence, dizziness, ataxia, fatigue, nystagmus; diplopia, amblyopia, tremor, dysarthria, amnesia, back pain; children also: viral infection, fever, nausea, vomiting, emotional lability, thought disorder, hyperkinesia, hostility.
How Supplied:
Caps, tabs—100; Soln—470mL
