部份中文依沙匹隆处方资料（仅供参考）
英文药名: Ixempra(Ixabepilone Injections)

中文药名: 伊沙匹隆注射剂

研发厂家:施贵宝公司
药品介绍
Ixempra（Ixabepilone，伊沙匹隆）是一种类似紫杉醇微管蛋白聚合和抑制微管解聚活性的埃坡霉素(epothilones)类抗肿瘤化疗新药，由施贵宝公司研发生产。2007年10月FDA批准Ixempra单药或与卡培他滨联用用于治疗蒽环类、紫杉烷衍生物和卡培他滨治疗无效的转移性或局部进展的晚期乳腺癌。埃坡霉素(epothilones)：是一类十六元环的大环内酯类药物，最早由Holfe和Reichenbach两人在1992年从粘细菌Sorangium cellulosum种中分离得到，Ixabepilone（BMS-247550）是半合成epothilone β内酰胺类似物，属于新一代抗有丝分裂药物，其作用机制与紫杉醇类药物（taxanes）类似，可与微管蛋白结合导致癌细胞无法顺利进行有丝分裂，进而使癌细胞产生凋亡，在抗肿瘤谱、抗肿瘤活性、安全性、水溶性及合成方法等方面均优于紫杉醇。
Ixempra是第一个埃博霉素类全新抗肿瘤药物，可与微管蛋白结合而导致癌细胞不能顺利进行有丝分裂，最终使肿瘤细胞凋亡。Ixempra具有全新的化学结构，与紫杉类具有不同的微管结合位点，因此具有更强的抗肿瘤活性。而且，Ixempra对肿瘤耐药机制易感性低。 
IXEMPRA® (ixabepilone) is a prescription medicine used to treat locally advanced or metastatic breast cancer when certain other medicines have not worked or no longer work. IXEMPRA can be used alone or with another cancer medicine called Xeloda® (capecitabine).
Important Safety Information about IXEMPRA® (ixabepilone)
Your healthcare provider should do blood tests to check how well your liver is working before you begin treatment with IXEMPRA and as needed during treatment. If blood tests show that you have liver problems, do not receive injections of IXEMPRA along with capecitabine. If you have liver problems, taking these medicines together could increase your chance of serious infection and death due to a very low white blood cell count (neutropenia).
You should not have your injection of IXEMPRA if you:
•Are allergic to medicines that contain Cremophor® EL* (polyoxyethylated castor oil)
•Have a low white blood cell count or a low platelet count
Before you receive treatment with IXEMPRA, tell your healthcare provider about all of your medical conditions, including any of the following:
•Liver problems
•Heart problems or a history of heart problems
•An allergic reaction to IXEMPRA. (To lower the chance of an allergic reaction, you will receive other medicines about 1 hour before each dose of IXEMPRA)
•Diabetes
•Numbness, tingling, or burning in the hands or feet (neuropathy)
You should also tell your healthcare provider if you:
•Are pregnant or plan to become pregnant. IXEMPRA may harm your unborn baby
•Are breast-feeding. It is not known if IXEMPRA passes into breast milk
•Take any medicines, including prescription and nonprescription medicines, vitamins, and herbal supplements, including St John’s wort. IXEMPRA and certain other medicines may affect each other and cause side effects
While you are on treatment with IXEMPRA, you should avoid:
•Activities that may be dangerous, such as driving or operating machinery because IXEMPRA contains alcohol and may cause dizziness and drowsiness (feeling tired)
•Drinking grapefruit juice. Grapefruit juice may cause you to have too much IXEMPRA in your blood, and this can lead to side effects
IXEMPRA may cause serious side effects. Tell your healthcare provider right away if you have any of the following while taking IXEMPRA:
•Numbness, tingling, or burning in the hands or feet (neuropathy). When they do happen, these symptoms often appear early in treatment and may be new or get worse. Your dose of IXEMPRA may need to be decreased, stopped until your symptoms get better, or stopped totally
•Low white blood cell count (neutropenia). White blood cells help protect the body from infections caused by bacteria. Symptoms of neutropenia include fever (temperature over 100.5 degrees), chills, cough, and burning or pain when you urinate. If you get a fever or an infection when your white blood cell count is very low, you can become seriously ill and die. You may need treatment in the hospital with antibiotic medicines
•Allergic reactions. Signs of an allergic reaction include itching; hives; rash; flushed face; sudden swelling of the face, throat, or tongue; tightness in the chest; trouble breathing; feeling dizzy or faint; feeling your heart beating (palpitations). Allergic reactions are most likely to occur while IXEMPRA is being injected. Severe allergic reactions can occur with IXEMPRA and may cause death in rare cases
•Heart Problems. Chest pain, difficulty breathing, palpitations, or unusual weight gain. These can be caused by decreased blood flow to the heart, problems with heart function, and abnormal heartbeat
The most common side effects of IXEMPRA, when used alone or with capecitabine, may include:
•Tiredness
•Loss of appetite
•Problems with your toenails and fingernails
•Hair loss
•Fever
•Decreased red blood cell count (anemia)
•Joint and muscle pain
•Headache
•Decreased platelet count (thrombocytopenia)
•Nausea, vomiting, diarrhea, constipation, and abdominal pain
•Sores on the lip, in the mouth, and in the esophagus
•Tender, red skin on the palms of the hands and the soles of the feet (hand-foot syndrome). It may look like a sunburn. The skin may also become dry and peel or may feel numb and tingly
If you have any questions about your health or your medicines, talk with your healthcare provider. Click here to see the full Prescribing Information, including boxed WARNING regarding liver disease.