部份中文醋酸甲羟孕酮资料（仅供参考）
英文名：Medroxyprogesterone Acetate
商品名：Hysron-H Tab
中文名：醋酸甲羟孕酮片
生产商：协和发酵麒麟
药品简介
Hysron-H(Medroxyprogesterone Acetate)一种孕酮衍生物，临床上用于月经不调、功能性子宫出血及子宫内膜异位症等晚期乳腺癌、子宫体癌（内膜癌） . 
ヒスロンH錠200mg
类别名称
抗肿瘤口服促黄体激素制剂
欧文商標名
Hysron-H Tab. 200mg
一般名
メドロキシプロゲステロン酢酸エステル
Medroxyprogesterone Acetate
化学名
17-Hydroxy-6α-methyl-4-pregnene-3, 20-dione acetate
略名
MPA
分子式
C24H34O4
分子量
386.52
化学構造式
性状
白色至淡黄白色结晶性粉末，无臭味。
可溶性
它易溶于氯仿中，易溶略微丙酮或1,4-二恶烷，稍稍溶于乙腈或正丁基氯化铵，甲醇，乙醇（99.5），或微溶于乙醚，并在水或己烷几乎不溶。
熔点
204〜209℃
药效药理
1.抗肿瘤作用
（1）对乳腺癌的抗肿瘤作用
通过口服24、60和120mg/kg，观察到DMBA诱导的大鼠乳腺癌的剂量依赖性抗肿瘤作用。
使用人乳腺癌培养细胞MCF-7及其耐他莫昔芬的菌株R-27检查对菌落形成能力的影响的结果是，无论是否存在E2（雌二醇），两种菌株均为10-8至10-5mol/L。对细胞增殖表现出浓度依赖性的抑制作用。
另外，通过细胞数测定研究了对人乳腺癌细胞ZR-75-1的作用的结果，与E2的存在无关，在10-10和10-5mol/L下显示出浓度依赖性的细胞生长抑制作用。没有E2时的效果比存在E2时的效果更强。
（2）对子宫内膜癌的抗肿瘤作用
通过以0.1、10、100mg/kg/天的口服给药检查对移植到裸鼠中的人子宫内膜腺癌细胞AD-30的作用的结果，在每个给药组中观察到肿瘤倍增时间显着延长，并且观察到组织。在科学上，随着细胞的萎缩和萎缩，观察到体液成分在腺腔中的积累。
2.作用机理
认为通过对DNA合成的抑制作用，对垂体，肾上腺和性腺系统的抑制作用以及抗雌激素作用表现出抗肿瘤作用。
适应症
乳腺癌,子宫体癌（内膜癌）
用法用量
对于乳腺癌，醋酸甲羟孕酮的成人剂量通常为每日600至1200mg，分3次口服。
对于子宫体癌（子宫内膜癌），成年人通常每天口服2至3次分剂量口服400至600mg乙酸甲羟孕酮。
可以根据患者的症状调整剂量。
包装规格
Hislon H片200mg：[PTP] 100片（10片x 10）
制造商
协和发酵麒麟有限公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整处方资料附件：
https://www.info.pmda.go.jp/go/pack/2478002F3056_3_06/
Hysron-H Tab 200mg（Medroxyprogesterone Acetate）
Brand name:Hysron-H Tablets 200 mg
　Active ingredient: Medroxyprogesterone acetate
　Dosage form: White tablets, diameter 9.0 mm, thickness 3.5 mm
　Print on wrapping: KH405 HYSH 200 mg
Effects of this medicine
This medicine, a type of female hormone (luteal hormone), inhibits proliferation of hormone-dependent tumor cells by suppressing secretion of hormones that act on the pituitary gland and stimulate ovaries.
It is usually used in the treatment of breast cancer and uterine body cancer (endometrial cancer).
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are within 1 week after surgery.
If you have thrombotic disease (cerebral infarction, myocardial infarction, thrombophlebitis) (including history of the disease), arteriosclerosis, heart disease (heart valve disease, atrial fibrillation, endocarditis, heart failure, etc.).
If you are administering hormones. If you have undiagnosed genital bleeding, urinary tract bleeding or breast lesion, liver disorder or hypercalcaemia.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•Breast cancer: In general, for adults, take 1 to 2 tablets [200 to 400 mg of the active ingredient] 3 times daily.
Uterine body cancer (endometrial cancer): In general, for adults, take 400 to 600 mg of the active ingredient in 2 or 3 devided doses daily. This preparation contains 200 mg of the active ingredient in a tablet.
The dosage may be adjusted according to the symptoms. Strictly follow the instructions.
•If you miss a dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include weight gain, moon face, uterine bleeding, edema, thrombosis, menstruation disorder and vision disorder. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•foot pain/swelling, chest pain, vomiting blood [thrombosis]
•shortness of breath/breathing difficulty, general swelling, general malaise [congestive heart failure]
•shortness of breath/breathing difficulty, swelling around eyes and lips, hives [anaphylactoid symptoms]
•reduced visual acuity, bulging eyes, double vision, migraine [papilledema]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder.Do not store them.
Kyowa Hakko Kirin Co.,LtdInternal
Published: 8/2012
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.