Takelda（Aspirin/Lansoprazole）组合片是兰索拉唑和低剂量阿司匹林的固定剂量组合，现已在日本上市
2014年6月12日，武田制药宣布，治疗消化性溃疡的低剂量Takepron(lansoprazole，兰索拉唑)的固定剂量组合（“FDC”）组合片现已在日本上市。Takelda联合片将100mg阿司匹林与15mg兰索拉唑联合使用，是日本第一种将低剂量阿司匹林与质子泵抑制剂联合使用的FDC药物。
随着日本人口的快速老龄化，服用低剂量阿司匹林预防脑梗死或心肌梗死复发的患者数量正在增加。由于服用低剂量阿司匹林可能导致胃溃疡或十二指肠溃疡，因此预防该患者群体的溃疡发作非常重要。国内和国际指南建议联合使用质子泵抑制剂，尤其是有胃溃疡或十二指肠溃疡病史的患者。
根据2012年《公共健康保险医疗保健活动调查》，超过一半的脑梗死或缺血性心脏病患者服用五种或五种以上药物。现在，目前正在服用Takeplon和低剂量阿司匹林的患者可以通过改用Takelda来减少服药次数。此外，有胃或十二指肠溃疡病史并服用低剂量阿司匹林的患者将能够更好地预防溃疡的发展，而不会增加他们服用的药丸数量。
武田制药营销部主任兼高级副总裁Masato Iwasaki博士表示：“经历过心血管事件的患者需要长期服用低剂量阿司匹林，以防止复发。我们相信，在有胃溃疡或十二指肠溃疡病史并同时服用低剂量阿斯匹林和竹原的患者中，武尔达联合片可以改善药物依从性。我们努力为患者和医生提供非常方便的治疗选择。”
*患者积极参与疗程或政策的决策，并相应地实施和继续治疗。
关于Takelda®复方片
商品名：Takelda® Combination Tablets
通用名：Aspirin/Lansoprazole
用量与用法
通常，成人每天口服一片100毫克阿司匹林/15毫克兰索拉唑。
适应症：
有胃溃疡或十二指肠溃疡病史且有以下情况的患者血栓形成和栓塞的风险降低。
-患有心绞痛（慢性稳定型心绞痛和不稳定性心绞痛）、心肌梗死和缺血性脑血管疾病[短暂性脑缺血发作（TIA）、脑梗死]的患者
-在接受过冠状动脉搭桥术（CABG）或经皮冠状动脉腔内成形术（PTCA）的患者中。
完整说明书资料附件：
https://www.info.pmda.go.jp/go/pack/3399102F1026_2_04/
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TAKELDA Combination Tablets（Aspirin/Lansoprazole）タケルダ配合錠
Brand name : TAKELDA Combination Tablets
Active ingredient: Aspirin
Lansoprazole
Dosage form: white to yellowish white tablet with redbrown to dark-brown flecks, diameter 10.0 mm, thickness 5.4 mm
Print on wrapping: (face) タケルダ, 水でお飲みください (back) タケルダ, アスピリン・ランソプラゾール配合
Effects of this medicine
Aspirin inhibits activities of platelet cyclooxygenase-1 to suppress platelet aggregation and eventually delay or prevent blood coagulation while lansoprazole inhibits the enzymatic activity of proton pump in the gastric mucosa to suppress gastric acid secretion.
Aspirin prevents obstruction of a blood vessel by a blood clot that has formed but may cause gastric or duodenal ulcers; therefore, lansoprazole prevents such untoward events.
It is usually used to suppress thrombus/embolus formation due to angina pectoris, myocardial infarction, or ischemic cerebrovascular disorder or to suppress thrombus/embolus formation after coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA) in patients with a history of gastric or duodenal ulcers.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have peptic ulcer, hematological disorder or a history of hematological disorder, bleeding tendency or predisposition to bleeding tendency, bronchial asthma or a history of bronchial asthma, liver disorder or a history of liver disorder, renal disorder or a history of renal disorder.
If you drink alcohol on a regular basis.
If you are scheduled for surgery, cardiac catheter test or tooth extraction.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule presc |
