新型凝胶Andractim DHT 2.5% Gel（Dihydrotestosterone 中文译名：双氢睾酮）为全球第一款高效外用新药(一般用药18天就能见效)，主要用于治疗先天阴茎短小及男性增大阴茎疾病。
英文名：Dihydrotestosterone
商品名：Andractim DHT 2.5% Gel
中文名：双氢睾酮（又称二氢睾酮）
生产商：法国Besins公司
作用
睾酮可直接或先转变为活性更强的双氢睾酮,与生精细胞的雄激素受体结合,促进精子的生成.所以,双氢睾酮的作用主要是有：
1.维持产生精子作用；
2.刺激生殖器官的发育,促进男性第二性征出现并维持其正常形态；
3.维持正常的性欲；
4.促进蛋白质的合成,特别是肌肉和生殖器官的蛋白质的合成,同时还能促进骨骼生长与钙磷的沉积和红细胞的生成。
适应症：
主要治疗：成年和儿童先天阴茎短小疾病及男子女性乳房发育、小阴茎、性腺功能减退、降低分解代谢，例如艾滋病引起的消瘦、女性硬化萎缩性苔藓，男性避孕。
【特点】
5a-双氢睾酮是天然产生的活性最强的雄性激素，在体内的生物活性是睾酮的6倍。睾酮在体内发挥生理作用主要通过在靶细胞代谢为双氢睾酮。双氢睾酮透皮吸收凝胶在1982年上市，由Laboratoires Besins International公司(Paris, France)开发，对于皮肤没有刺激性，最初双氢睾酮凝胶用于治疗男子女性乳房发育、小阴茎以及女性硬化萎缩性苔藓，后来适应症扩大，可以用于治疗性腺功能减退和降低分解代谢，例如艾滋病引起的消瘦，以及男性避孕。现在，一种新的0.7%双氢睾酮凝胶制剂正在进行III期临床实验。和目前广泛使用的睾酮及其衍生物相比较，双氢睾酮由于在体内不能转化成雌二醇，所以双氢睾酮不会产生男子女性乳房发育的副作用；并且在临床研究中发现，双氢睾酮可以使老年男性性腺功能减退患者前列腺的体积变小，所以，双氢睾酮与目前上市的睾酮及其衍生物相比较，有相对的优点。
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Dihydrotestosterone(Andractim®)2.5% gel for topical application for 16 once-daily applications
1 Tubes (16 once-daily), 2 Tubes (32 once-daily) and PSA KIT and 4 Tubes (64 once-daily) and PSA KIT
1 Tubes enough for 16 days
2 Tubes enough for 32 days
4 Tubes enough for 64 days
Dihydrotestosterone is a synthetic version of a hormone called testosterone. It is used for children with hormone deficiencies. This information sheet from Great Ormond Street Hospital (GOSH) explains what andractim 2.5% gel is, how it is used and some of the possible side effects.
It is available as a 2.5% gel under the brand name Andractim®, which is imported from abroad. It works by correcting the hormone deficiency, either in a particular part of the body or affecting the body as a whole.
How is it used?
Dihydrotestosterone 2.5% gel is for external use only. It should be applied over the required area of skin after washing. The gel should be left to dry for five minutes or so before putting on clothes.
Put on a pair of gloves
Gently squeeze the gel onto the mark on the ruler illustrated on the laminated information sheet – as instructed on the dispensing label.
Spread over the required area evenly
Leave for five minutes
Wipe the laminated information sheet with a damp piece of kitchen paper ready for the next dose. Remove the gloves and wash them in warm soapy water ready for the next dose.
Note: Dihydrotestosterone 2.5% gel should not be applied to any broken areas of skin.
Who should not use Dihydrotestosterone 2.5% gel?
People who are hypersensitive to Dihydrotestosterone or its excipients (Carbomer 934, triethanolamine, Alcohol 95%) should discuss using this medicine with their doctor.
What are the side effects?
The following side effects are rare and are usually due to the dose being too high, so will disappear when the dosage is reduced.
Mood swings and irritability
Excessive energy or signs of being hyperactive
Weight gain
Extra hair growth
Hoarseness
Oily skin
Acne
Dihydrotestosterone 2.5% gel and other medicines
Dihydrotestosterone is applied externally so it should not react with any other medicines. |
