ics.
In this randomized comparative study, the usefulness of a topical application of 1% lanoconazole cream (Astat®) monotherapy (group I) was compared with that of combination therapy with 1% lanoconazole cream and 10% urea ointment (Pastaron®) (group II) in a series of patients with hyperkeratotic type tinea pedis.
The clinical improvement rates (percentage of ‘marked improvement’ plus ‘moderate improvement’) was 70.0% in group I and 95.7% in group II.
The fungal eradication rate was 5.0% in group I and 43.5% in group II after 4 weeks of treatment, and was 70.0% and 95.7% after 12 weeks of treatment, respectively.
The usefulness rate (percentage of ‘very useful’ plus ‘useful’) was 70% in group I and 95.7% in group II.
Both lanoconazole monotherapy and the combination therapy with 10% urea ointment were highly effective and safe.
Both treatments should be recommended for patients with hyperkeratotic type tinea pedis for whom an oral treatment is not appropriate or for whom a sufficient improvement with oral medications cannot be expected.
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