|
0
|
|
Uncommon
|
Gastrointestinal perforationb, d
|
0.3
|
0
|
0.3
|
|
Anal fistulab
|
0.3
|
0
|
0
|
|
Skin and subcutaneous tissue disorders
|
Very Common
|
Palmar-plantar erythrodysaesthesia (hand-foot syndrome)
|
27.3
|
5.0
|
0
|
|
Rash
|
11.7
|
0.3
|
0
|
|
Dry skin
|
10.0
|
0
|
0
|
|
Common
|
Pruritus
|
5.8
|
0
|
0
|
|
Erythema
|
2.2
|
0
|
0
|
|
Alopecia
|
3.3
|
0
|
0
|
|
Musculoskeletal and connective tissue disorders
|
Common
|
Myalgia
|
5.3
|
0.6
|
0.3
|
|
Arthralgia
|
8.6
|
0.6
|
0
|
|
Pain in extremity
|
8.9
|
0.3
|
0
|
|
Renal and urinary disorders
|
Very Common
|
Proteinuria
|
10.3
|
3.1
|
0
|
|
Common
|
Renal failuree
|
1.1
|
0.6
|
0
|
|
General disorders and administration site conditions
|
Very Common
|
Fatigue
|
34.8
|
9.5
|
0.3
|
|
Asthaeniac
|
17.5
|
3.6
|
0.3
|
|
Mucosal inflammation
|
15.0
|
1.4
|
0
|
|
Investigations
|
Very Common
|
Weight decreased
|
16.4
|
1.4
|
0
|
|
Common
|
Thyroid stimulating hormone increased
|
4.5
|
0
|
0
|
|
Lipase increased
|
2.2
|
0.6
|
0
|
|
Alanine aminotransferase increased
|
1.9
|
0.3
|
