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s) observed in patients treated with lenalidomide/dexamethasone: Investigations Uncommon: Prolonged prothrombin time, prolonged activated partial thromboplastin time, increased International Normalised Ratio, increased blood alkaline phosphatase, increased blood lactate dehydrogenase, increased C-Reactive Protein, Cytomegalovirus antibody positive Cardiac disorders Common: Atrial fibrillation, palpitations Uncommon: Congestive cardiac failure, pulmonary oedema, heart valve insufficiency, atrial flutter, arrhythmia, ventricular trigeminy, bradycardia, tachycardia, QT prolongation, sinus tachycardia Congenital, familial and genetic disorders Uncommon: Chromosome abnormality Blood and lymphatic system disordersVery Common: Neutropenia*, thrombocytopenia*, anaemia* Common: Febrile neutropenia, pancytopenia, leucopenia*, lymphopenia* Uncommon: Granulocytopenia, haemolytic anaemia, autoimmune haemolytic anaemia, haemolysis, hypercoagulation, coagulopathy, monocytopenia, leucocytosis, lymphadenopathy Nervous system disorders Common: Cerebrovascular accident, syncope, peripheral neuropathy, neuropathy, peripheral sensory neuropathy, dizziness, ageusia, dysgeusia, paraesthesia, headache, tremor*, hypoaesthesia*, somnolence, memory impairment Uncommon: Intracranial haemorrhage, intracranial venous sinus thrombosis, thrombotic stroke, cerebral ischaemia, transient ischaemic attack, leukoencephalopathy, neurotoxicity, polyneuropathy, peripheral motor neuropathy, dysaesthesia, aphonia, dysphonia, disturbance in attention, ataxia, balance impaired, postural dizziness, burning sensation, cervical root pain, dyskinesia, hyperaesthesia, motor dysfunction, myasthenic syndrome, oral paraesthesia, psychomotor hyperactivity, anosmia Eye disorders Common: Blurred vision, cataract, reduced visual acuity, lacrimation increased Uncommon: Blindness, retinal arteriosclerosis, retinal vein thrombosis, keratitis, visual disturbance, eyelid oedema, conjunctivitis, eye pruritus, eye redness, eye irritation, dry eye Ear and labyrinth disorders Common: Vertigo Uncommon: Deafness, hypoacusia, tinnitus, ear pain, ear pruritus Respiratory, thoracic and mediastinal disorders Common: Pulmonary embolism, dyspnoea*, exertional dyspnoea, bronchitis, cough, pharyngitis, nasopharyngitis, hoarseness, hiccups Uncommon: Bronchopneumopathy, asthma, respiratory distress, pulmonary congestion, pleuritic pain, nasal congestion, throat secretion increased, laryngitis, sinus congestion, sinus pain, rhinorrhoea, dry throat Gastrointestinal disorders Very Common: Constipation, diarrhoea, nausea, increase and decrease in weight Common: Vomiting, dyspepsia, upper abdominal pain, gastritis, abdominal distension, abdominal pain, stomatitis, dry mouth, flatulence Uncommon: Gastrointestinal haemorrhage, peptic ulcer haemorrhage, oesophagitis, gastrooesophageal reflux disease, colitis, caecitis, gastroduodenitis, aptyalism, proctitis, gastroenteritis, oesophageal pain, dysphagia, odynophagia, haemorrhoids, epigastric discomfort, aphthous stomatitis, cheilitis, glossodynia, gingivitis, lip ulceration, tongue ulceration, oral pain, toothache, sensitivity of teeth, gingival bleeding, oral hypoaesthesia, lip pain, coated tongue Renal and urinary disorders Common: Renal failure Uncommon: Acute renal failure, urinary frequency, renal tubular nec |
